On superparacompact and Lindelof GO-spaces

In this paper we study some compact/paracompact type properties, namely weak superparacompactness, superparacompactness and Lindelofness. Particular attention is given to GO-spaces. It is proved that a GO-space X is weakly superparacompact if and only if every gap is a W- gap and every pseudogap is a W-pseudogap. A characterization of Lindelof GO-spaces involving C-(pseudo)gaps is given. We also show that there is a 1-l correspondence between superparacompact (resp. LindelGf) GO-d- extensions and preuniversal ODF (resp. prelindelsf) GO-uniformities. Finally we give several examples corresponding to the above results.peer-reviewe

Aging and Degradation Behavior Elucidated by Viscoelasticity Aiming Protection of Smart City Facilities

Polymer coatings play a crucially important role in protecting smart city facilities against the harsh factors of outdoor environments. Recent increased awareness of eco‐friendliness has led to the use of waterborne organic coatings. Research into the bulk material properties of these coatings is necessary in order to understand their degradation process in the field. The present work focuses attention on a unique rheological property, which has both elastic and viscous characteristics, as a means of assessing the stability of the coating. The viscoelastic property determines whether it presents solid‐like or liquid‐like response from the comparison of relative strengths of the relaxation time (τ) and operating time (t). In the process of degradation, both the storage (E′) and loss modulus (E″), which represent the elastic and viscous components, respectively, decrease accordingly, reflecting the deterioration of coating. The majority of the water molecules absorbed in a coating are strongly bound to the polymer network through hydrogen bonds with polar functional groups, which destroys intermolecular bonding between macromolecules and reduces the bulk materials’ ability to diffuse stress concentrations and thereby lowers a coating’s overall strength

On metrizable type (MT-) maps and spaces

In this paper we define and study MT-maps, which are the fibrewise topological analogue of metrizable spaces, i.e., the extension of metrizability from the category Top to the category TopY. Several characterizations and properties of MT-maps are proved. The notion of an MT-space as an MT-map preimage of a metrizable space is introduced. Examples of MT-spaces and their relation with M-spaces are given. Finally it is deduced that an MT-space with a Gδ-diagonal is metrizable.peer-reviewe

Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.

Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS

Effect of Including Sand Component in a Debris Flow on Concentration of Coarser Particles at the Flow Front

We conducted flume experiments for a debris flow consisting of coarser particles, finer particles and sand, focusing on the concentration of coarser particles at the flow front. Our experimental results revealed that the concentration of coarser particles at the flow front using sediment mixture with sand was less than that without sand. This may be because including of sand component in the material contributed to be a smaller averaged interstice between particles in the flow layer and a smaller averaged particle size. These may lead to reduce the falling volume of sand or finer particles and dispersion pressure for the rise of coarser particles, respectively, resulting in the inhibition of inverse grading formation. Our experimental results also suggested that the changing trend in the proportion of finer particles depended on the relationship between their particle size and the average particle size of the flow. These are consistent with our previous experimental results using material without sand. This consistency suggested that for the concentration of coarser particles at the flow front, the behavior of the sand component can be considered in the same manner as other coarser-sized components

Sppecific Radioactivity of Europium-152 in Roof Tiles Exposed to Atomic Bomb Radiation in Nagasaki

金沢大学大学院自然科学研究科物質情報解析金沢大学理学

Effect of Oral Functional Training on Changes in Resting Saliva Secretion in Older Hemodialysis Patients

高齢血液透析患者の口腔乾燥には，日常的な水分摂取の制限と唾液腺自体の加齢性変化が関係していると考えられる．高齢血液透析患者の口腔乾燥改善には，まず十分な安静時唾液の分泌が必要と考え，それを促す手法の一つとして口腔機能訓練に着目した．本研究は，高齢血液透析患者に対して継続的な口腔機能訓練を行い，安静時唾液量の変化から訓練の効果を検証することを目的とした． 研究参加の同意が得られた軽度以上の口腔乾燥を有する高齢血液透析患者を，無作為に2群に分けた．歯科衛生士による口腔機能訓練（唾液腺マッサージ，舌運動訓練）を透析中（週3回）に12週間行った群を介入群，行わなかった群を対照群とした．研究開始前，2週後，4週後，8週後および12週後に，口腔内湿潤度と安静時唾液量を測定した．研究を完了した54名（介入群28名，対照群26名）について，群内および群間の比較には二元配置分散分析を，計測回ごとの多重比較にはBonfferoni法を用いて，統計解析を行った． 口腔機能訓練の実施による変化を検証した結果，口腔内湿潤度は，介入群の主効果および対照群との交互作用も有意であった（F（1,52）＝22.3，p＝0.03，F（4）＝3.5，p＝0.008）．群内の多重比較の結果，介入群は研究開始時と比較して，4週後以降で有意差が認められた（p＜0.05，p＜0.001，p＜0.05）が，対照群は有意差が認められなかった．安静時唾液は，介入群の主効果および対照群との交互作用も有意（F（1,52）＝18.6，p＜0.001，F（3）＝5.3，p＝0.002）であった．群内の多重比較の結果，介入群において，研究開始前と比較して4週後以降（p＜0.05，p＜0.001，p＜0.001）に有意な増加が認められた．一方，対照群において，2週後と12週後，4週後と12週後に有意な増加が認められた（p＜0.05，p＜0.05）．以上より，高齢血液透析患者に対する長期間（4週間以上）の唾液腺マッサージや舌運動訓練による口腔機能訓練は，安静時唾液分泌量を増加させる可能性が示唆された．Introduction:　Daily fluid restriction and aging-related atrophy of saliva glands might cause dry mouth in older hemodialysis patients. We hypothesized that greater saliva secretion is needed to relieve dry mouth and that this could be achieved by providing oral functional training to patients. The aim of this study was to investigate changes in resting saliva secretion after performing oral functional training for older hemodialysis patients with mild dry mouth. Materials and Methods:　Hemodialysis patients with mild dry mouth at Kawashima Hospital gave informed consent to participate in the study. They were then randomly divided into an intervention group (n＝31) and a control group (n＝30). The intervention group was provided oral functional training by a dental hygienist, including saliva gland massage for 30 s and tongue lateral movement for 12 weeks during dialysis treatment. The control group did not receive the training. Overall, 54 participants completed the experiment. Oral wetness was measured using a KISO-WeT Tester, and the amount of resting saliva secreted in 30 s was collected in a cotton roll and weighed. Measurements were implemented at baseline and at 2, 4, 8, and 12 weeks after starting the regimen. Results and Discussion:　In the intervention group, oral wetness at 4, 8, and 12 weeks was significantly higher than that at baseline (p＜0.05, p＜0.001, p＜0.05, respectively). No statistically significant differences were found in the control group. In the intervention group, the amounts of saliva secreted at 4, 8, and 12 weeks were significantly greater than that at baseline (p＜0.05, p＜0.001, p＜0.001, respectively). In the control group, the amount of saliva secreted at 12 weeks was significantly more than that at 2 and 4 weeks (p＜0.05, p＜0.05, respectively). Conclusion:　We concluded that performing oral functional training, which included salivary gland massage and tongue movement training for 4 or more weeks, could increase the amount of resting saliva secretion in older hemodialysis patients with mild dry mouth

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.

The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer. A pancreatic cancer patient-derived orthotopic xenograft (PDOX) that was VEGF-positive and an orthotopic VEGF-positive human pancreatic cancer cell line (MiaPaCa-2-GFP) as well as a VEGF-negative cell line (Panc-1) were tested. Nude mice with these tumors were treated with gemcitabine (GEM), bevacizumab (BEV), and S. typhimurium A1-R. BEV/GEM followed by S. typhimurium A1-R significantly reduced tumor weight compared to BEV/GEM treatment alone in the PDOX and MiaPaCa-2 models. Neither treatment was as effective in the VEGF-negative model as in the VEGF-positive models. These results demonstrate that S. typhimurium A1-R following anti-angiogenic therapy is effective on pancreatic cancer including the PDOX model, suggesting its clinical potential