22 research outputs found
Environmental and vegetational changes recorded in sedimentary leaf wax n-alkanes across the Cretaceous–Paleogene boundary at Loma Capiro, Central Cuba
Renal pelvis cancer with initial symptoms of malignant gastric outlet obstruction
Introduction Gastric outlet obstruction caused by upper tract urothelial carcinoma is rare. Case presentation A 78‐year‐old man presented to the hospital with nausea and vomiting. No hematuria was observed. Computed tomography revealed a tumor in the right renal pelvis and duodenal stenosis. Gastrojejunostomy was performed to treat the symptoms of the gastric outlet obstruction so that the patient could resume oral intake and outpatient chemotherapy. Chemotherapy was unsuccessful, and the patient died 9 months after the gastrojejunostomy. Histological assessment of an autopsy specimen revealed plasmacytoid urothelial carcinoma with direct infiltration of the duodenal wall, which caused the stenosis. Conclusion Autopsy revealed a right renal pelvis cancer causing gastric outlet obstruction. Early gastrojejunostomy enabled oral intake and outpatient visits
Randomized, controlled trial comparing S-1 with UFT/LV as adjuvant therapy for curatively resected stage III colorectal cancer (BCOG-CC02 study).
Characterization of the Interunit Bonds of Lignin Oligomers Released by Acid-Catalyzed Selective Solvolysis of Cryptomeria japonica and Eucalyptus globulus Woods via Thioacidolysis and 2D-NMR
Acid-catalyzed degradation of lignin
in toluene containing methanol
selectively yields C6–C2 lignin monomers and releases lignin
oligomers, a potential raw feedstock for epoxy resins. We herein characterize
the structures of the lignin oligomers by focusing on the changes
in the interunit linkage types during solvolysis. The oligomeric lignin
products were analyzed via thioacidolysis and 2D-HSQC-NMR. The results
show that lignin oligomers ranging from monomers to tetramers are
released through considerable cleavage of the β-<i>O</i>-4 linkages. The lignin oligomers from Cryptomeria
japonica (softwood) mainly comprise β-5, β-1,
and tetrahydrofuran β-β linkages, whereas Eucalyptus globulus (hardwood) yields oligomers rich
in β-1 and syringaresinol β-β linkages. Both wood
samples exhibit selective release of β-β dimers and a
relative decrease in 5-5 and 4-<i>O</i>-5 bonds during solvolysis.
The method presented for the separation of lignin oligomers without
β-<i>O</i>-4 linkages and with linkages unique to
each wood species will be useful for the production of lignin-based
materials
Enhancement of cytotoxicity of doxorubicin by verapamil in the hepatic artery infusion for liver tumors in rats
Mo1798 Daikenchuto (DKT) Helps Improve Postoperative Functional Gastrointestinal Disorder After Total Gastrectomy in Patients With Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial(JFMC42-1002)
Effects of soil erosion and anoxic–euxinic ocean in the Permian–Triassic marine crisis
The largest mass extinction of biota in the Earth’s history occurred during the Permian–Triassic transition and included two extinctions, one each at the latest Permian (first phase) and earliest Triassic (second phase). High seawater temperature in the surface water accompanied by euxinic deep-intermediate water, intrusion of the euxinic water to the surface water, a decrease in pH, and hypercapnia have been proposed as direct causes of the marine crisis. For the first-phase extinction, we here add a causal mechanism beginning from massive soil and rock erosion and leading to algal blooms, release of toxic components, asphyxiation, and oxygen-depleted nearshore bottom water that created environmental stress for nearshore marine animals. For the second-phase extinction, we show that a soil and rock erosion/algal bloom event did not occur, but culmination of anoxia–euxinia in intermediate waters did occur, spanning the second-phase extinction. We investigated sedimentary organic molecules, and the results indicated a peak of a massive soil erosion proxy followed by peaks of marine productivity proxy. Anoxic proxies of surface sediments and water occurred in the shallow nearshore sea at the eastern and western margins of the Paleotethys at the first-phase extinction horizon, but not at the second-phase extinction horizon. Our reconstruction of ocean redox structure at low latitudes indicates that a gradual increase in temperature spanning the two extinctions could have induced a gradual change from a well-mixed oxic to a stratified euxinic ocean beginning immediately prior to the first-phase extinction, followed by culmination of anoxia in nearshore surface waters and of anoxia and euxinia in the shallow-intermediate waters at the second-phase extinction over a period of approximately one million years or more. Enhanced global warming, ocean acidification, and hypercapnia could have caused the second-phase extinction approximately 60 kyr after the first-phase extinction. The causes of the first-phase extinction were not only those environmental stresses but also environmental stresses caused by the soil and rock erosion/algal bloom event