A 48-Hour Holter ECG Study in Migraineurs during Usual Daily Activities

In order to clarify the condition of cardiac autonomic nervous activity in migraineurs, 48-h Holter electrocardiograms (ECGs) were carried out under free activity on 20 migraineurs during headache free periods and 20 healthy controls. We calculated hourly standard deviation (SD), root mean square successive differences (RMSSD), the proportion fo cycles during which the RR difference is > 50 ms (%RR50), low frequency heart rate fluctuation (LF), high frequency heart rate fluctuation (HF) and LF/HF ratio from heart rate variability, and obtained serial 24 data of these parameters. SD, RMSSD, %RR50 and HF are parasympathetic parameters, and LF/HF is sympathetic. These parameters were fit to cosines curve and analyzed circadian rhythms using the cosinor method. By group mean cosinor analysis, the vectors of the amplitude-acrophases of SD, RMSSD, %RR50, LF, HF and LF/HF significantly differed in the migraineurs from those in the controls. The significant differences of vectors of SD, RMSSD, %RR50 and HF indicate cardiac parasympathetic dysfunction. Midline estimating statistic of rhythms (MESORs) of those parameters did not significantly differ except in LF and LF/HF between both groups. MESORs of LF and LF/HF were significantly decreased in the migraineurs, which indicates cardiac sympathetic hypofunction. We concluded that migraineurs might have cardiac parasympathetic dysfunction and sympathetic hypofunction. By evaluating circadian rhythms using cosinor methods, the parameters of heart rate variability in migraineurs were significantly different from controls. Migraineurs may have some disturbance in their rhythm generator

日本におけるSUNCT/SUNAの臨床像 : クリニックベースの研究

Objectives:This study aimed to report the clinical profiles of patients with short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial autonomic (SUNA) in a Japanese population by surveying those enrolled at a regional headache center in Japan.Methods:In this consecutive case series study, the clinical characteristics of patients with SUNCT (eight men, three women; mean age: 59.5 ± 20.5 years) and SUNA (five men, four women; mean age: 51.3 ± 18.4 years) who visited Tominaga Hospital from February 2011 to January 2017 were examined. Headaches were diagnosed according to the International Classification of Headache Disorders, Third edition (ICHD-3) guidelines.Results:Brief clusters of separate attacks were reported by all patients. The mean duration of attacks was 91.9 ± 87.9 s. Ipsilateral rhinorrhea was observed in 9 of 20 (45.0%) cases and facial sweating was observed in 1 of 20 (5.0%) cases. An eminent response to lamotrigine was observed in 9 of 9 (100%) patients; however, adverse events were only reported in 2 of 9 (22.2%) cases. An intravenous infusion of lidocaine was demonstrated to be completely successful for short-term prevention in 5 of 6 (83.3%) SUNCT cases.Conclusions:Lamotrigine can successfully treat most patients, and intravenous lidocaine is useful for the short-term preventive therapy of severe recalcitrant attacks in Japanese patients with SUNCT/SUNA.博士（医学）・乙第1437号・令和元年9月27日Copyright © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)

Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

Rs in cardiogenesis remain unclear.Rs mimicked the phenotype of the AV valve defect that result from the inhibition of calcineurin, and it could be rescued by constitutively active calcineurin.Rs in cardiogenesis in part through the regulation of calcineurin-NFAT signaling

Rapid, simple, and effective strategy to produce monoclonal antibodies targeting protein structures using hybridoma technology

Highlights ・MIHS-SAST screening generates mAbs that target protein structures. ・One-fourth of the mAbs recognized stereospecific epitopes of the protein. ・Two fluorometric parameters aided in selecting antibodies with strong binding constants

sj-pdf-2-cep-10.1177_03331024231156925 - Supplemental material for Developing an artificial intelligence-based headache diagnostic model and its utility for non-specialists’ diagnostic accuracy

Supplemental material, sj-pdf-2-cep-10.1177_03331024231156925 for Developing an artificial intelligence-based headache diagnostic model and its utility for non-specialists’ diagnostic accuracy by Masahito Katsuki, Tomokazu Shimazu, Shoji Kikui, Daisuke Danno, Junichi Miyahara, Ryusaku Takeshima, Eriko Takeshima, Yuki Shimazu, Takahiro Nakashima, Mitsuhiro Matsuo and Takao Takeshima in Cephalalgia</p

sj-pdf-1-cep-10.1177_03331024231156925 - Supplemental material for Developing an artificial intelligence-based headache diagnostic model and its utility for non-specialists’ diagnostic accuracy

Supplemental material, sj-pdf-1-cep-10.1177_03331024231156925 for Developing an artificial intelligence-based headache diagnostic model and its utility for non-specialists’ diagnostic accuracy by Masahito Katsuki, Tomokazu Shimazu, Shoji Kikui, Daisuke Danno, Junichi Miyahara, Ryusaku Takeshima, Eriko Takeshima, Yuki Shimazu, Takahiro Nakashima, Mitsuhiro Matsuo and Takao Takeshima in Cephalalgia</p