13 research outputs found
Goblet Cell Hyperplasia and Muscular Layer Thickening in the Small Intestine of a Cynomolgus Monkey
We report here the interesting case of a 5-year-old male cynomolgus monkey with
goblet cell hyperplasia and thickening of the muscular layer throughout the
small intestine without exhibiting any clinical symptoms. Necropsy examination
showed diffuse thickening of the intestinal wall from the jejunum to the ileum,
with an appearance likened to a rubber tube. Histopathologically, marked
thickening was observed in both the mucosal and muscular layers in the jejunum
and ileum, and slight thickening was observed in the duodenum. Goblet cell
hyperplasia with extension of the circular folds and villi was prominently
observed. The mucosal surface was covered with a thick mucus layer containing
desquamated mucosal epithelial cells, and both the inner and outer muscular
layers were markedly thickened due to smooth muscle hypertrophy. Neither
macroscopic nor histopathological examination identified any causative factors,
such as infection, enteritis and intestinal stenosis, or obstruction that may
have caused development of this lesion. Given these observations, this case may
simply be considered of spontaneous goblet cell hyperplasia and muscular layer
thickening in the small intestine of a cynomolgus monkey