Distribution of Major Health Risks: Findings from the Global Burden of Disease Study

BACKGROUND: Most analyses of risks to health focus on the total burden of their aggregate effects. The distribution of risk-factor-attributable disease burden, for example by age or exposure level, can inform the selection and targeting of specific interventions and programs, and increase cost-effectiveness. METHODS AND FINDINGS: For 26 selected risk factors, expert working groups conducted comprehensive reviews of data on risk-factor exposure and hazard for 14 epidemiological subregions of the world, by age and sex. Age-sex-subregion-population attributable fractions were estimated and applied to the mortality and burden of disease estimates from the World Health Organization Global Burden of Disease database. Where possible, exposure levels were assessed as continuous measures, or as multiple categories. The proportion of risk-factor-attributable burden in different population subgroups, defined by age, sex, and exposure level, was estimated. For major cardiovascular risk factors (blood pressure, cholesterol, tobacco use, fruit and vegetable intake, body mass index, and physical inactivity) 43%–61% of attributable disease burden occurred between the ages of 15 and 59 y, and 87% of alcohol-attributable burden occurred in this age group. Most of the disease burden for continuous risks occurred in those with only moderately raised levels, not among those with levels above commonly used cut-points, such as those with hypertension or obesity. Of all disease burden attributable to being underweight during childhood, 55% occurred among children 1–3 standard deviations below the reference population median, and the remainder occurred among severely malnourished children, who were three or more standard deviations below median. CONCLUSIONS: Many major global risks are widely spread in a population, rather than restricted to a minority. Population-based strategies that seek to shift the whole distribution of risk factors often have the potential to produce substantial reductions in disease burden

Physical Processes in Star Formation

© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s11214-020-00693-8.Star formation is a complex multi-scale phenomenon that is of significant importance for astrophysics in general. Stars and star formation are key pillars in observational astronomy from local star forming regions in the Milky Way up to high-redshift galaxies. From a theoretical perspective, star formation and feedback processes (radiation, winds, and supernovae) play a pivotal role in advancing our understanding of the physical processes at work, both individually and of their interactions. In this review we will give an overview of the main processes that are important for the understanding of star formation. We start with an observationally motivated view on star formation from a global perspective and outline the general paradigm of the life-cycle of molecular clouds, in which star formation is the key process to close the cycle. After that we focus on the thermal and chemical aspects in star forming regions, discuss turbulence and magnetic fields as well as gravitational forces. Finally, we review the most important stellar feedback mechanisms.Peer reviewedFinal Accepted Versio

The persuasive effects of positive and negative social feedback from an embodied agent on energy conservation behavior.

In this paper we explore the persuasive effects of social feedback, as provided by an embodied agent, on behavioral change. In a lab setting an experiment was conducted in which participants had the opportunity to conserve energy while carrying out washing tasks with a simulated washing machine. The experiment tested the effect of positive and negative social feedback and compared these effects to more widely used factual feedback. The robotic source, a so-called iCat, was manipulated with regard to its perceived agency. The results showed an effect of social feedback compared to factual feedback. In addition an effect of feedback valence was found, demonstrating more conservation actions following negative social feedback. The predicted perceived agency effect could not be demonstrated

Satisficing and the use of keyboard shortcuts: Being good enough is enough?

Item does not contain fulltextKeyboard shortcuts are generally accepted as the most efficient method for issuing commands, but previous research has suggested that many people do not use them. In this study we investigate the use of keyboard shortcuts further and explore reasons why they are underutilized by users. In Experiment 1, we establish two baseline findings: (1) people infrequently use keyboard shortcuts and (2) lack of knowledge of keyboard shortcuts cannot fully account for the low frequency of use. In Experiments 2 and 3, we furthermore establish that (3) even when put under time pressure users often fail to select those methods they themselves believe to be fastest and (4) the frequency of use of keyboard shortcuts can be increased by a tool that assists users learning keyboard shortcuts. We discuss how the theoretical notion of ‘satisficing’, adopted from economic and cognitive theory, can explain our results.13 p