Nematic elastomers with aligned carbon nanotubes: new electromechanical actuators

We demonstrate, for the first time, the large electromechanical response in nematic liquid crystalline elastomers filled with a very low (~0.01%) concentration of carbon nanotubes, aligned along the nematic director at preparation. The nanotubes create a very large effective dielectric anisotropy of the composite. Their local field-induced torque is transmitted to the rubber-elastic network and is registered as the exerted uniaxial stress of order ~1kPa in response to a constant field of order ~1MV/m. We investigate the dependence of the effect on field strength, nanotube concentration and reproducibility under multiple field-on and -off cycles. The results indicate the potential of the nanotube-nematic elastomer composites as electrically driven actuators

Association of serum fetuin-A and biochemical parameters in hemodialysis patients.

Fetuin-A, a hepatic glycoprotein present in the circulation, is a potential inhibitor for systemic calcification. The main aim of this study was to evaluate the association between fetuin-A and other biochemical parameters as facilitator factors for developing atherosclerosis in hemodialysis (HD) patients. This case-control study was conducted on 44 HD patients undergoing treatment in 2012. Parathormone (i-PTH) and fetuin levels were performed by the enzyme-linked immunosorbent assay method, high-sensitivity C-reactive protein (hs-CRP) by chemiluminescence, low-density lipoprotein by direct enzymatic, calcium and albumin by colorimetric and phosphorous by ultraviolet (UV) methods. Chi-square was used for evaluating the association between variables and t-test was used for comparing the mean of the quantitative variables for the two groups. SPSS-16 software was used for data analysis and P-value less than 5% was considered as significant. Mean of serum fetuin level was 23.25 ± 4.90 ng/mL in HD patients and 32.92 ± 5.21 in the control group. Median of hs-CRP was 2.45 mg/dL in the patients and 1.00 mg/dL in the control group and i-PTH was 74.3 pg/mL in the patients and 7.30 pg/mL in the control group. The calcium-phosphorous product was 46.77 ± 14.22 mg/dL in the patient and 31.73 ± 6.48 mg/dL in the control group. A reverse significant association was found between fetuin-A and hs-CRP in this study. In this study, serum fetuin-A level in HD patients was lower than controls. Therefore, a low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition

Instability indices and forecasting thunderstorms: the case of 30 April 2009

In this paper, one meteorological case study for two Iranian airports are presented. Attempts have been made to study the predefined threshold amounts of some instability indices such as vertical velocity and relative humidity. Two important output variables from a numerical weather prediction model have been used to survey thunderstorms. The climatological state of thunder days in Iran has been determined to aid in choosing the airports for the case studies. The synoptic pattern, atmospheric thermodynamics and output from a numerical weather prediction model have been studied to evaluate the occurrence of storms and to verify the threshold instability indices that are based on Gordon and Albert (2000) and Miller (1972). <br><br> Using data from the Statistics and Data Center of the Iran Meteorological Organization, 195 synoptic stations were used to study the climatological pattern of thunderstorm days in Iran during a 15-yr period (1991–2005). Synoptic weather maps and thermodynamic diagrams have been drawn using data from synoptic stations and radiosonde data. A 15-km resolution version of the WRF numerical model has been implemented for the Middle East region with the assistance of global data from University Corporation for Atmospheric Research (UCAR). <br><br> The Tabriz airport weather station has been selected for further study due to its high frequency of thunderstorms (more than 35 thunderstorm days per year) and the existence of an upper air station. Despite the fact that storms occur less often at the Tehran weather station, the station has been chosen as the second case study site due to its large amount of air traffic. Using these two case studies (Tehran at 00:00 UTC, 31 April 2009 and Tabriz at 12:00 UTC, 31 April 2009), the results of this research show that the threshold amounts of 30 °C for KI, −2 °C for LI and −3 °C for SI suggests the occurrence and non-occurrence of thunderstorms at the Tehran and Tabriz stations, respectively. The WRF model output of vertical velocity and relative humidity are the two most important indices for examining storm occurrence, and they have a numerical threshold of 1 m s<sup>−1</sup> and 80%, respectively. These results are comparable to other studies that have examined thunderstorm occurrence

Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis.

Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca � P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions

Titanium dioxide nanoparticles catalyzed synthesis of Hantzsch esters and polyhydroquinoline derivatives

1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30-120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse

The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature

In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions. We show that the chick occipital lateral plate mesoderm has myogenic capacity and gives rise to large muscles located in the neck and thorax. We present molecular and genetic evidence to show that these muscles not only have a unique origin, but additionally display a distinct temporal development, forming later than any other muscle group described to date. We further report that these muscles, found in the body of the animal, develop like head musculature rather than deploying the programme used by the trunk muscles. Using mouse genetics we reveal that these muscles are formed in trunk muscle mutants but are absent in head muscle mutants. In concordance with this conclusion, their connective tissue is neural crest in origin. Finally, we provide evidence that the mechanism by which these neck muscles develop is conserved in vertebrates

Developments in sandwich construction

The research is divided into two parts. In the firstpart the structural behaviour of sandwich beams usingtimber-based facings and foamed plastic cores wasstudied. Various available theories were examined andthe most appropriate theory for this type of panel wasidentified. In an extensive test programme the relevantproperties of the constituent materials were measuredand the data used in the proposed theory of structuralbehaviour to predict beam deflections and core andfacing stresses. Corresponding sandwich beam tests werecarried out on the range of skin/core combinations andthe theoretical and experimental behaviours werecompared. Good agreement was confirmed within the rangeof span/depth ratios investigated, confirming theapplicability of the theory for semi-thick timber-basedfacings. A variety of timber based facings wereinvestigated and those most suitable for sandwichconstruction were identified.This type of panel construction has many advantages butlacks the benefit of good fire resistance. The recF.iiredfire resistance could be provided by a suitable corematerial.Part two of the research concentrated on the developmentof a new core material which was intended to have goodstructural properties at reasonable density, and to haveadequate fire resistance free from the production of smoke and toxic fumes. Coated paper honeycombs werechosen for the study. The properties of the constituentmaterials were investigated in detail and then thestructural properties of the developed cores weremeasured using methods drawn from national andinternational standards. One particular coatingcombination proved to be effective in terms ofstiffness, fire resistance, freedom from micro crackingand strength retention at high temperature. This wasbased on a mixture of sodium silicate and ball clay.Cores were tested both with cells empty (to be blockedby intumescence) and with cells filled (e.g. withlightweight filler). In the best of the developed cores,shear stiffness and transverse stiffness were muchhigher than in normal core materials. On the basis ofthe test programme, panels can be designed to give afire resistance defined by insulation of up to two hours

Detection of Pseudomonas aeruginosa in sputum samples by modified fluorescent in situ hybridization

Pseudomonas aeruginosa is the most common and dominant infectious agent that causes chronic pneumonia in patients with cystic fibrosis (CF). Fluorescent in situ hybridization (FISH) is a powerfulmolecular method for the specific and rapid diagnosis of bacteria, including the detection of P. aeruginosa in sputum samples from CF patients. High background fluorescence of viscous sputumsamples obtained from CF patients may impede detection of microorganisms by FISH. The aim of this study was to test the application of biotin during FISH technique to reduce unspecific background fluorescence in sputum samples to facilitate and improve detection of P. aeruginosa. Sixty-three sputum samples from CF patients were tested by FISH to detect P. aeruginosa. All the 63 samples were also examined by a modified FISH procedure including biotin treatment. The FISH results were compared with those of conventional culture method. The specificity of FISH was 100%. The sensitivity of FISH for detection of P. aeruginosa from samples without biotin treatment was 83.3%, whereas in biotin-treated samples was 88.1%. Biotin reduced background fluorescence of 12 sputum samples of CF patients and it did not show any adverse effect on FISH results of the remaining sputum samples. Therefore, using of biotin in FISH procedure seems to facilitate and improve the detection of respiratorytract infections by P. aeruginosa in this population

Anticancer activity of Sargassum oligocystum water extract against human cancer cell lines

Background and Objectives: Antitumor drug resistance and side effects of antitumor compounds are the most common problems in medicine. Therefore, finding new antitumor agents with low side effects could be interesting. This study was designed to assay antitumor activity of the extract from brown alga Sargassum oligocystum, gathered from Persian Gulf seashore, against K562 and Daudi human cancer cell lines. Materials and Methods: The research was performed as an in vitro study. The effect of the alga extract on proliferation of cell lines were measured by two methods: MTT assay and trypan blue exclusion test. Results and Conclusion: The most effective antitumor activity has been shown at concentrations 500 μg/ml and 400 μg/ml of the alga extract against Daudi and K562 cell lines, respectively. The results showed that the extracts of brown alga Sargassum oligocystum have remarkable antitumor activity against K562 and Daudi cell lines. It is justified to be suggested for further research such as algal extract fractionation and purification and in vivo studies in order to formulate natural compounds with antitumor activities