Titanium dioxide nanoparticles catalyzed synthesis of Hantzsch esters and polyhydroquinoline derivatives

Abstract

1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30-120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse