Background and Objectives:
Antitumor drug resistance and side effects of
antitumor compounds are the most common
problems in medicine. Therefore, finding new
antitumor agents with low side effects could be
interesting. This study was designed to assay
antitumor activity of the extract from brown alga
Sargassum oligocystum, gathered from Persian
Gulf seashore, against K562 and Daudi human
cancer cell lines.
Materials and Methods: The research was
performed as an in vitro study. The effect of
the alga extract on proliferation of cell lines
were measured by two methods: MTT assay
and trypan blue exclusion test.
Results and Conclusion: The most effective
antitumor activity has been shown at concentrations
500 μg/ml and 400 μg/ml of the alga
extract against Daudi and K562 cell lines,
respectively. The results showed that the extracts
of brown alga Sargassum oligocystum
have remarkable antitumor activity against
K562 and Daudi cell lines. It is justified to be
suggested for further research such as algal
extract fractionation and purification and in vivo
studies in order to formulate natural compounds
with antitumor activities
