Projektierung von statistischen Erhebungen mit oertlich und zeitlich differenzierter Aussage ueber die Taetigkeiten der Feuerwehren, Leitstellen und Brandschutzdienststellen

Available from TIB Hannover: RA 2039(125) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Visualization of surface acoustic waves in thin liquid films

We demonstrate that the propagation path of a surface acoustic wave (SAW), excited with an interdigitated transducer (IDT), can be visualized using a thin liquid film dispensed onto a lithium niobate (LiNbO3) substrate. The practical advantages of this visualization method are its rapid and simple implementation, with many potential applications including in characterising acoustic pumping within microfluidic channels. It also enables low-cost characterisation of IDT designs thereby allowing the determination of anisotropy and orientation of the piezoelectric substrate without the requirement for sophisticated and expensive equipment. Here, we show that the optical visibility of the sound path critically depends on the physical properties of the liquid film and identify heptane and methanol as most contrast rich solvents for visualization of SAW. We also provide a detailed theoretical description of this effect

Searching for common ground: existing literature on automotive agile software product lines

The need for creating digitally enhanced products, services, and experiences as well as the emergence of new or modified business models has a significant impact on the automotive domain. Innovative solutions and new topics such as Smart Mobility or Connectivity require current automotive development processes to undergo major changes. They need to be redesigned in a way that it is possible to learn and adapt continuously at a fast pace. Agile methods are promising approaches to address these new challenges. However, agile methods are not tailored to the specific characteristics of the automotive domain such as software product line (SPLs) development. Although, there have been efforts to apply agile methods in the automotive domain, widespread adoptions have not yet taken place

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD. Here, we show that factor H (HF1), the major inhibitor of the alternative complement pathway, accumulates within drusen and is synthesized by the retinal pigmented epithelium. Because previous linkage analyses identified chromosome 1q25-32, which harbors the factor H gene (HF1/CFH), as an AMD susceptibility locus, we analyzed HF1 for genetic variation in two independent cohorts comprised of ≈900 AMD cases and 400 matched controls. We found association of eight common HF1 SNPs with AMD; two common missense variants exhibit highly significant associations (I62V, χ(2) = 26.1 and P = 3.2 × 10(-7) and Y402H, χ(2) = 54.4 and P = 1.6 × 10(-13)). Haplotype analysis reveals that multiple HF1 variants confer elevated or reduced risk of AMD. One common at-risk haplotype is present at a frequency of 50% in AMD cases and 29% in controls [odds ratio (OR) = 2.46, 95% confidence interval (1.95-3.11)]. Homozygotes for this haplotype account for 24% of cases and 8% of controls [OR = 3.51, 95% confidence interval (2.13-5.78)]. Several protective haplotypes are also identified (OR = 0.44-0.55), further implicating HF1 function in the pathogenetic mechanisms underlying AMD. We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population