Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide

AbstractChemotherapy treats many types of cancer effectively but it often causes side effects. Chemotherapy works on active cells, such as cancer cells, and some healthy cells. Side effects happen when chemotherapy damages these healthy cells. Today, many more drugs are available to treat side effects than in the past. Triptorelin (Decapeptyl) is a gonadotropin-releasing hormone agonist that is reported to have many therapeutic effects besides being an anti-cancer agent. In the current study, intraperitoneal cyclophosphamide (65mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats. After 4 weeks, we observed significant degeneration of neurocytes with dystrophic changes. Subcutaneous triptorelin (0.05mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis. Anti-Bcl2 staining of sections of the cerebral cortex and hippocampus showed that the apoptotic index was increased. This finding was confirmed by the anti-p53 staining, which showed a significant decrease in the apoptotic index. Ultimately, such improvements were accompanied by significant restoration of normal brain histology, as revealed by hematoxylin and eosin. In conclusion, triptorelin can reverse the apoptotic changes induced by cyclophosphamide therapy, which is more marked in the hippocampus than cerebral cortex

Pollination and serological studies on Egyptian grapes

White Roumi grape (Vitis vinifera L.) produces low yield when planted alone. Both pollination and serological tests indicated that this problem appears to be due to the presence of partial self-incompa·tibility in its flowers. Cross-pollination is necessary in White Roumi vineyards in order to obtain abundant yields and to improve berry quality.Different degrees of cross-compatibility were found between White Roumi flowers and four grape pollina.tors. Evaluating these pollinators indicated that Red Roumi and Thompson Seedless pollen gave the highest berry set and fruiting. BezEl-N akah resulted in early ripening berries possessing the largest weight and size. Ghariby proved to be an unsuitable pollinator of White Roumi flowers. It decreased  berry-set percentage and fruiting and increased percentage qf preharvest berry drop. Moreover, the berries were of poor quality.Bestäubungsversuche und serologische Untersuchungen an ägyptischen RebenDie Rebsorte White Roumi (Vitis vinifera L.) bringt allein gepflanzt nur niedrige Traubenerträge. Sowohl Bestäubungsexperimente als auch die serologische Prüfung zeigten, daß es sich hierbei um eine partielle Selbstinkompatibilität handeln dürfte. In Rebanlagen mit White Roumi ist Fremdbestäubung erforderlich, um reichliche Ernten zu erzielen und die Beerenqualität zu verbessern.Zwischen den Blüten von White Roumi und vier Pollenspendern wurden unterschiedliche Grade der Fremdverträglichkeit festgestellt. Bei Bestäubung mit Pollen von Red Roumi und Thompson Seedless waren der Beerenansatz und Fruchtertrag am höchsten. Pollen von Bez-El-Nakah hatte eine frühe Beerenreife zur Folge; die Beeren dieser Kreuzung waren am schwersten und größten. Die Sorte Ghariby erwies sich als ungeeigneter Pollenspender für die White-Roumi-Blüten; der Beerenansatz und Traubenertrag waren vermindert und der Anteil der vor der Ernte abgefallenen Beeren erhöht. Überdies waren die Beeren von geringer Qualität

An innovative fractal monopole MIMO antenna for modern 5G applications

Proposed in this paper is the design of an innovative and compact antenna array which based on four radiating elements for multi-input multi-output (MIMO) antenna applications used in 5G communication systems. The radiating elements are fractal curves excited using an open-circuited feedline through a coplanar waveguide (CPW). The feedline is electromagnetically coupled to the inside edge of the radiating element. The array's impedance bandwidth is enhanced by inserting a ground structure composed of low-high-low impedance between the radiating elements. The low-impedance section of the ground is a staircase structure that is inclined at an angle to follow the input feedline. This inter-radiating element essentially suppresses near-field radiation between adjacent radiators. A band reject filter based on a composite right/left hand (CRLH) structure is mounted at the back side of the antenna array to reduce mutual coupling between the antenna elements by choking surface wave propagations that can otherwise degrade the radiation performance of the array antenna. The CRLH structure is based on the Hilbert fractal geometry, and it was designed to act like a stop band filter over the desired frequency bands. The proposed antenna array was fabricated and tested. It covers the frequency bands in the range from 2 to 3 GHz, 3.4-3.9 GHz, and 4.4-5.2 GHz. The array has a maximum gain of 6. 2dBi at 3.8 GHz and coupling isolation better than 20 dB. The envelope correlation coefficient of the antenna array is within the acceptable limit. There is good agreement between the simulated and measured results.Dr. Mohammad Alibakhshikenari acknowledges support from the CONEX-Plus programme funded by Universidad Carlos III de Madrid and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 801538. Funding for APC: Universidad Carlos III de Madrid (Read & Publish Agreement CRUE-CSIC 2022)

Theoretical review of routing protocols used for wireless community networks

Wireless community networks (WCNs) are a solution for people who are living in some areas facing difficulties for accessing the internet because no ISPs are providing them with the service due to the long distance, the high cost of infrastructure, and the less no of people in these areas. So people decided to build their own internet without the need for ISPs. They build mesh networks to provide WiFi access to the internet. WCNs are consideredas large-scale, distributed and decentralized systems. Inaddition, it consists of numerous nodes, links, content, and services. These networks are constructed in a decentralized way, mixing wired and wireless links with different routing techniques with a different range of applications and services. Therefore, they are very dynamic and diverse. There is an open peering agreement that governs these networks, where it avoids impediments for the participation in the network. The ownership, governance, and knowledge of the network are open. For that reason, WCNs are decentralized as well as they are self-managed and self-owned by community members. Moreover, they are self-growing networks in links, capacity, and services provided. This paper presents a critical analysis of thecurrent routing protocols that are employed for WCNs. In addition, it highlights the strengths and weaknesses of each routing protocol

Iron Deficiency Anaemia In Reproductive Age Women Attending Obstetrics And Gynecology Outpatient Of University Health Centre In Al-Ahsa, Saudi Arabia

Background: Iron deficiency is the most common nutritional disorder in the world. The aim of this questionnaire based survey study was to determine the prevalence of iron deficiency anemia in reproductive age women, and their relation to variables such as age, marital status, education with those attending obstetrics and gynecology outpatient of King Faisal University Health Centre in Al-Ahsa in eastern region of Kingdom of Saudi Arabia.Materials and Methods: This study was conducted for the period of 6 month staring from September 2012 to February 2013. The questionnaire had three sections on personal information: their educational indicators, gynecological clinical history, and hematological indices.Results: The average age was 25.97±7.17 years. According to the  gynecological clinical history of the respondents, 15 (48.4%) respondents were pregnant while 16 (51.6%) were not pregnant. There was significant effect of pregnancy status on Hb level. Majority of the anemic respondents 15/17 were married. Moreover 14/17 anemic women were experiencing severe menstrual bleeding, 11/17 respondents were pregnant. 54.8% of respondents were hemoglobin deficient while 77.4% were found to have low Hct. In 87.1 % of the respondents, transferrin saturation was found to be abnormal.Conclusion: In this study iron deficiency anemia is quite prevalent in the university community especially among pregnant women. The fetus’s and newborn infant’s iron status depends on the iron status of the pregnant woman and therefore, iron deficiency in the mother-to-be means that growing fetus probably will be iron deficient as well. Thus iron deficiency anemia during pregnancy in well-educated set up needs more attention by the concerned authorities.Keywords: Iron deficiency Anemia (IDA), Hemoglobin, Female, Reproductive Age

SIGNALING PATHWAYS REGULATED BY BRASSICACEAE EXTRACT INHIBIT THE FORMATION OF ADVANCED GLYCATED END PRODUCTS IN RAT BRAIN

Background: The goal of this study was identification signaling molecules mediated the formation of AGEs in brain of rats injected with CdCl2 and the role of camel whey proteins and Brassicaceae extract on formation of AGEs in brain. Methods: Ninety male rats were randomly grouped into five groups; Normal control (GpI) and the other rats (groups II-V) were received a single dose of cadmium chloride i.p (5 μg/kg/b.w) for induction of neurodegeneration. Rats in groups III-V were treated daily with whey protein (1g/kg b.w) or Brassicaceae extract (1mg/kg b.w) or combined respectively for 12 weeks. Results: It was found that whey protein combined with Brassicaceae extract prevented the formation of AGEs and enhance the antioxidant activity compared with untreated group (

Detection and Classification of Conflict Flows in SDN Using Machine Learning Algorithms

Software-Defined Networking (SDN) is a new type of technology that embraces high flexibility and adaptability. The applications in SDN have the ability to manage and control networks while ensuring load balancing, access control, and routing. These are considered the most significant benefits of SDN. However, SDN can be influenced by several types of conflicting flows which may lead to deterioration in network performance in terms of efficiency and optimisation. Besides, SDN conflicts occur due to the impact and adjustment of certain features such as priority and action. Moreover, applying machine learning algorithms in the identification and classification of conflicting flows has limitations. As a result, this paper presents several machine learning algorithms that include Decision Tree (DT), Support Vector Machine (SVM), Extremely Fast Decision Tree (EFDT) and Hybrid (DT-SVM) for detecting and classifying conflicting flows in SDNs. The EFDT and hybrid DT-SVM algorithms were designed and deployed based on DT and SVM algorithms to achieve improved performance. Using a range flows from 1000 to 100000 with an increment of 10000 flows per step in two network topologies namely, Fat Tree and Simple Tree Topologies, that were created using the Mininet simulator and connected to the Ryu controller, the performance of the proposed algorithms was evaluated for efficiency and effectiveness across a variety of evaluation metrics. The experimental results of the detection of conflict flows show that the DT and SVM algorithms achieve accuracies of 99.27% and 98.53% respectively while the EFDT and hybrid DT-SVM algorithms achieve respective accuracies of 99.49% and 99.27%. In addition, the proposed EFDT algorithm achieves 95.73% accuracy on the task of classification between conflict flow types. The proposed EFDT and hybrid DT-SVM algorithms show a high capability of SDN applications to offer fast detection and classification of conflict flows