Apoptotic functions of microRNAs in pathogenesis, diagnosis, and treatment of endometriosis

MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. Endometriosis is a malignant gynecologic disorder occurring in women before menopausal age. Pathogenesis of this illness is still a discussion subject between the scientists but in our knowledge, microRNAs can be one of the possible involved factors. The purpose of this paper is to investigate the role of apoptotic activities of miRNAs in endometriosis. Accumulative evidence has demonstrated the role of cell proliferation, apoptosis, and invasion in the progression of these diseases. In this review, we looked into the specific role of apoptosis and its related genes and pathways in endometriosis and tied to present an explanation of how miRNAs can affect endometriosis by their apoptotic activities. What we found is that a great extent of miRNAs is involved in this illness and they are responsible for repressing apoptosis and progression of the disease. As a result, miRNAs have two different usages in endometriosis: biomarkers and potential therapeutic targets. In this review we gathered a great amount of evidence to inquire into the role of micro RNAs in inducing apoptosis and how this mechanism can be exerted for therapeutic purposes for endometriosis. © 2020 The Author(s)

Quercetin and cancer: New insights into its therapeutic effects on ovarian cancer cells

Ovarian cancer is known as a serious malignancy that affects women's reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involved in ovarian cancer pathogenesis making it difficult to develop effective therapeutic platforms. Hence, discovery and developing new therapeutic approaches are required. Medicinal plants, as a new source of drugs, could potentially be used alone or in combination with other medicines in the treatment of various cancers such as ovarian cancer. Among various natural compounds, quercetin has shown great anti-cancer and anti-inflammatory properties. In vitro and in vivo experiments have revealed that quercetin possesses a cytotoxic impact on ovarian cancer cells. Despite obtaining good results both in vitro and in vivo, few clinical studies have assessed the anti-cancer effects of quercetin particularly in the ovarian cancer. Therefore, it seems that further clinical studies may introduce quercetin as therapeutic agent alone or in combination with other chemotherapy drugs to the clinical setting. Here, we not only summarize the anti-cancer effects of quercetin but also highlight the therapeutic effects of quercetin in the ovarian cancer. © 2020 The Author(s)

Apoptotic functions of microRNAs in pathogenesis, diagnosis, and treatment of endometriosis

MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. Endometriosis is a malignant gynecologic disorder occurring in women before menopausal age. Pathogenesis of this illness is still a discussion subject between the scientists but in our knowledge, microRNAs can be one of the possible involved factors. The purpose of this paper is to investigate the role of apoptotic activities of miRNAs in endometriosis. Accumulative evidence has demonstrated the role of cell proliferation, apoptosis, and invasion in the progression of these diseases. In this review, we looked into the specific role of apoptosis and its related genes and pathways in endometriosis and tied to present an explanation of how miRNAs can affect endometriosis by their apoptotic activities. What we found is that a great extent of miRNAs is involved in this illness and they are responsible for repressing apoptosis and progression of the disease. As a result, miRNAs have two different usages in endometriosis: biomarkers and potential therapeutic targets. In this review we gathered a great amount of evidence to inquire into the role of micro RNAs in inducing apoptosis and how this mechanism can be exerted for therapeutic purposes for endometriosis. © 2020 The Author(s)

A Critical Survey of Comparative Studies conducted about Rūmī and Mathnawi

This paper aims to investigate the comparative studies done on Rūmī in the past decade and elaborate on their strengths and weaknesses with use of time-based, journals-status and content-based and journals’ specialty sampling as methodology. The findings showed that most of the papers suffered from serious drawbacks such as inadequate coverage and familiarity with subject matter, overgeneralization, superficial analysis and hasty conclusions. Some writers' traditional and subjective approach to the issue was much highlighted in certain journals, whereas few enjoyed scientific precision. Other defects that can be listed include: lack of systematic methodology, false inferences, inappropriate references, selection of insignificantEste documento tiene como objetivo investigar los estudios comparativos realizados sobre Rūmī en la última década y detallar sus fortalezas y debilidades con el uso del tiempo, el estado de las revistas y el muestreo de especialidades basado en el contenido y las revistas como metodología. Los hallazgos mostraron que la mayoría de los artículos presentaban serias desventajas, como cobertura inadecuada y familiaridad con el tema, sobre generalización, análisis superficial y conclusiones apresuradas. El enfoque tradicional y subjetivo de algunos escritores al tema fue muy destacado en ciertas revistas, mientras que pocos disfrutaron de precisión científica. Otros defectos que se pueden enumerar incluyen: falta de metodología sistemática, inferencias falsas, referencias inapropiadas, selección de insignificante

Circular RNA as a potential diagnostic and/or therapeutic target for endometriosis

Endometriosis is a pathology form of endometrium that behaves in a similar way to malignancies, such as invasion and resistance to apoptosis. Circular RNAs (CircRNAs) are a class of noncoding RNAs that have several biological functions including, miRNA sponging, sequestering of proteins, enhancing parental gene expression and translation resulting in polypeptides. In this review, we highlighted the roles of circRNAs as potential diagnostic and therapeutic biomarkers in endometriosis. Moreover, we summarized the roles of circRNAs in the pathogenesis of endometriosis via different signaling pathways, such as the miRNA network and apoptosis. © 202