Inflammatory myofibroblastic lung tumor: its birth, its bleeding growth, its difficult diagnosis and its surgical end in a child

The diagnosis of inflammatory myofibroblastic tumor is based on radiology and histology. The treatment is surgical, and the prognosis is good. For this reason, although this lung disease is rare, when a child show up at hospital with an unknown hemoptysis, this medical condition should not be underestimated

Bone Marrow Foot Oedema in Adolescents: The Role of Vitamin D

BACKGROUND: Bone marrow oedema (BMO) in children/adolescents is a rare clinical condition without an etiologic cause. It is associated with typical increased signal intensity on T2-weighted magnetic resonance images (MRI) and an increase in bone turnover in which vitamin D plays a pivotal role. No treatment guidelines for these young patients are to date available. METHODS: We performed a retrospective study in a pediatric setting of 13 patients with diagnosis of primary BMO of the foot on the basis of clinical and radiological findings. Data collection included sex, age, patient history, symptoms at presentation, clinical examination, laboratory bone turnover markers, vitamin D levels, MRI, treatment, and outcome. RESULTS: Vitamin D deficiency or insufficiency was found in 76.9% of cases. All patients were treated with adequate vitamin D daily intake, a short course of analgesic therapy, physical therapy, avoiding detrimental feet and ankle immobilization. All fully recovered in 3-month lag period. CONCLUSIONS: Our data highlight that environmental factors, such as underestimated articular or bone microtraumatisms, as well as joint hyper mobility, in a bone turnover milieu of vitamin D deficiency could be the cause of this clinical conditions. Adequate vitamin D supplementation, associated with physical and analgesic therapy, is crucial in the management of BMO

Epidemiology of type 1 diabetes mellitus in the pediatric population in Veneto Region, Italy

We assessed the prevalence and incidence of type 1 diabetes mellitus (T1DM) in Veneto Region in Italy. The average prevalence and incidence rates were 1.26/1000 subjects and 16.5/100,000 person-years, respectively. This study shows that the Veneto Region is an area with intermediate-high risk of T1DM

Duration of topical therapy in the maintenance of atopic dermatitis remission in paediatric age

BACKGROUND: Topical Corticosteroids (TCS) are the first-choice treatment for atopic dermatitis (AD) flares. In literature there are clear advices about the potency, dosage and frequency of application of TCS, but there are no shared indications about duration of the treatment during a flare. The aim of the study is to demonstrate if the use of a steroid cream for less than or 5 days , could be equal or more effective than the application for more than 5 days during a flare episode, in keeping a remission state of DA. METHODS: The study population (n=122) was selected according to the following inclusion criteria: at least one specialist allergological and dermatological examination in the period November 2015 to February 2017, age between 1 and 11 years; mild to moderate atopic dermatitis. All patients were given a standardized telephone questionnaire, which concerns on multiple aspects: parents' self-reported perceptions of the severity of their child's condition; actual use of emollients, moisturizers and steroid creams; number of consecutive days of using of topical steroid cream during an exacerbation of AD; average number of AD exacerbations per month in the last year; total number of AD exacerbations in the last year. RESULTS: Data from 96 patients was examined. We classified three groups of patients from data collected: group 1 (n=40): use of TCS for 64 5 consecutive days during an exacerbation event of AD; group 2 (n=12): use of TCS for > 5 consecutive days during an exacerbation event of AD; group 3 (n=44): non use of TCS or use of TCS with a different posology. We found a further subgroup in group 3 (3a, n=27) with patients using only emollient cr\ue8me in AD management. In group 1, 27 patients (67.5%) didn't show a good AD control; on the contrary, 13 patients (27.5%) reported a good AD control. In group 2, 4 patients (25%) didn't show a good AD control; on the contrary, 8 patients (75%) reported a good AD control. By comparing the data obtained in the presence of good DA control, the difference between the percentages obtained was found to be statistically significant (p = 0.034). CONCLUSIONS: The results obtained show that a therapeutic pattern based on the use of TCS for a duration of more than 5 consecutive days during an episode of DA exacerbation is more efficient than the proposed alternative therapeutic scheme in the maintenance of DA remission

Caracterização das atividades desenvolvidas pelo Centro de Informações sobre Medicamentos (CIM-HCPA): período de 2007 - 2010

Objetivo: O objetivo do estudo foi descrever as atividades do Centro de Informações sobre Medicamentos do Hospital de Clínicas de Porto Alegre (CIM-HCPA), no período de 2007 a 2010.Resultados: A média de solicitações passivas, no período, foi de 1160/ano e de informação ativa de 160/ano. O programa de Farmacovigilância recebeu 1340 notificações de reações adversas a medicamentos e 155 notificações de produtos com problemas. A literatura disponível é atualizada e compatível conforme as recomendações. Na pesquisa de satisfação, 43% dos usuários classificaram o trabalho como ótimo.Conclusão: O CIM-HCPA vem cumprindo seus objetivos, fornecendo informação objetiva, atualizada e oportuna sobre medicamentos para os profissionais da instituição

Caracterização das atividades desenvolvidas pelo Centro de Informações sobre Medicamentos (CIM-HCPA): período de 2007 - 2010

Objetivo: O objetivo do estudo foi descrever as atividades do Centro de Informações sobre Medicamentos do Hospital de Clínicas de Porto Alegre (CIM-HCPA), no período de 2007 a 2010.Resultados: A média de solicitações passivas, no período, foi de 1160/ano e de informação ativa de 160/ano. O programa de Farmacovigilância recebeu 1340 notificações de reações adversas a medicamentos e 155 notificações de produtos com problemas. A literatura disponível é atualizada e compatível conforme as recomendações. Na pesquisa de satisfação, 43% dos usuários classificaram o trabalho como ótimo.Conclusão: O CIM-HCPA vem cumprindo seus objetivos, fornecendo informação objetiva, atualizada e oportuna sobre medicamentos para os profissionais da instituição