Asuhan Kebidanan Berkelanjutan Pada Ny.E.S di Puskesmas Oelolok Periode 20 April 2019 sampai dengan 10 Juni 2019

Latar Belakang: Angka kematian di wilayah NTT terutama Kabupaten Timor Tengah Utara terbilang cukup tinggi. Berdasarkan data yang dilaporkan oleh Bidang Kesehatan Keluarga tercatat tahun 2018 AKI di Kabupaten Timor Tengah Utara sebesar 0/100.000 KH. AKB di Kabupaten tahun 2018 sebesar 20 Kasus. Dengan dilakukan asuhan kebidanan secara berkelanjutan pada ibu hamil Trimester III sampai dengan perawatan masa nifas diharapkan dapat memberikan kontribusi dalam upaya menurunkan AKI dan AKB di Indonesia serta tercapai kesehatan ibu dan anak yang optimal. Tujuan: Menerapkan asuhan kebidanan secara berkelanjutan pada Ny.E.S. ibu hamil Trimester III sampai dengan perawatan masa nifas dan KB. Metode: Studi kasus menggunakan metode penelaahan kasus, lokasi studi kasus di Puskesmas Oelolok, subjek studi kasus adalah Ny.E.S. dan dilaksanakan pada tanggal 20 April 2019 sampai dengan 10 Juni 2019 dengan menggunakan format asuhan kebidanan pada ibu hamil dengan metode Varney dan pendokumentasian SOAP, teknik pengumpulan data menggunakan data primer dan data sekunder. Hasil: Ny.E.S. selama masa kehamilannya dalam keadaan sehat, proses persalinan berjalan normal dan melahirkan di puskesmas Oelolok, pada masa nifas involusi berjalan normal, bayi dalam keadaan sehat, konseling ber-KB ibu memilih metode suntik tiga bulanan.Simpulan: Penulis telah melakukan asuhan kehamilan, persalinan, nifas, bayi baru lahir dan keluarga berecana pada Ny.E.S. secara berkelanjutan dengan menggunakan 7 lagkah Varney dan pendokumentasian SOAP

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa.

Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not  shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats

A Sentiment Analysis of Filipinx on Twitter Using a Multinomial Naïve Bayes Classification Model

On social media, the use of “Filipinx” as a gender neutral, inclusive term for “Filipino” tends to generate high user engagement, at times without regard for the original context in which the word appears. This project applies computational methods to collect a large dataset in English/Filipino from Twitter containing “Filipinx”, and to train a Naïve Bayes model to classify tweets into three sentiments: positive, neutral, and negative. My methodology takes inspiration from that of four related studies that similarly conducted sentiment analysis on English/Filipino tweets involving various topics, and whose resulting accuracy scores were compared side-by-side. Conducting sentiment analysis on tweets that mention “Filipinx” would meet four goals: to compare the model’s performance with those from the previous four studies, to create a larger-scale picture of user sentiments about the use of “Filipinx” than what I previously presented in a small-scale sociolinguistics project, and to contribute to conversations on how Filipino social media users discursively define Filipino identity

Integrated Disease Investigations and Surveillance planning: a systems approach to strengthening national surveillance and detection of events of public health importance in support of the International Health Regulations

The international community continues to define common strategic themes of actions to improve global partnership and international collaborations in order to protect our populations. The International Health Regulations (IHR[2005]) offer one of these strategic themes whereby World Health Organization (WHO) Member States and global partners engaged in biosecurity, biosurveillance and public health can define commonalities and leverage their respective missions and resources to optimize interventions. The U.S. Defense Threat Reduction Agency’s Cooperative Biologica Engagement Program (CBEP) works with partner countries across clinical, veterinary, epidemiological, and laboratory communities to enhance national disease surveillance, detection, diagnostic, and reporting capabilities. CBEP, like many other capacity building programs, has wrestled with ways to improve partner country buy-in and ownership and to develop sustainable solutions that impact integrated disease surveillance outcomes. Designing successful implementation strategies represents a complex and challenging exercise and requires robust and transparent collaboration at the country level. To address this challenge, the Laboratory Systems Development Branch of the U.S. Centers for Disease Control and Prevention (CDC) and CBEP have partnered to create a set of tools that brings together key leadership of the surveillance system into a deliberate system design process. This process takes into account strengths and limitations of the existing system, how the components inter-connect and relate to one another, and how they can be systematically refined within the local context. The planning tools encourage cross-disciplinary thinking, critical evaluation and analysis of existing capabilities, and discussions across organizational and departmental lines toward a shared course of action and purpose. The underlying concepts and methodology of these tools are presented here

Sistem Informasi Geografis Objek Wisata Kabupaten Timor Tengah Selatan Berbasis Web

Kabupaten Timor Tengah selatan(TTS) merupakan kabupaten yang sangat dikenal karena memiliki daerah wisata yang banyak pada setiap kecamatan bahkan sampai desa-desa yang ada di Kabupaten TTS. Sistem informasi yang menyajikan informasi daerah-daerah wisata TTS telah banyak dibuat. Namun hanya menampilkan gambar dan namanya saja yang disajikan dalam bentuk peta kovensional, media iklan surat kabar juga yang belum menyajikan petunjuk langsung ke lokasi wisata yang dituju.Sistem Informasi yang ada masih memiliki kekurangan yaitu wisatawan tidak mendapatkan petunjuk langsung tantang lokasi wisata yang dituju. Oleh kerena itu dibutuhkan teknologi yang dapat menyajikan infromasi objek wisata yaitu Sistem informasi geografis (SIG) Seperti halnya dengan informasi yang memberi penjelasan dalam informasi wisata harus meliputi data dan gambar yang nyata dan benar. Sehingga para wisatawan yang ingin bepergian ke Kabupaten TTS tetapi masih belum tahu lokasi atau tempat objek wisata yang menarik untuk dikunjungi dapat mengetahuinya. Untuk mengatasi masalah tersebut penulis menggunakan pendekatan pada model pemetaan digital berupa SIG dengan berbasis Web memanfaatkan google maps sebagai peta digital. Aplikasi akan dikembangkan dengan program PHP, dan database MySQL sebagai penyimpanan data. Sistem informasi Geografis (SIG) objek wisata alam ini memiliki dua program yaitu program admin untuk mengelola data wisata berbasis web dan program user untuk menampilkan objek wisata berbasis web. Sistem informasi geografis ini bertujuan untuk memberikan kemudahan dan kecepatan kepada masyarakat dalam memperoleh informasi mengenai Objek Wisata Alam di TTS

Sosialisasi Konsep Ecoliteracy Fritjof Capra Dalam Perspektif Laudato Si´ bagi Umat Kapela Oemolo, Paroki Oécusse, Timor Leste dan Penerapannya melalui Penghijauan

Persoalan kerusakan lingkungan akibat ulah manusia yang antroposentrisme kini menjadi persoalan bersama yang patut ditanggapi secara serius demi kelangsungan hidup generasi manusia dan alam. Melek ekologi menjadi salah satu poin penting untuk menyadari pentingnya pemeliharaan lingkungan hidup bersama. Alam dan manusia diupayakan untuk memiliki hubungan mutualisme yang saling menghidupkan. Salah satu cara memperbaiki lingkungan yang rusak sekaligus memelihara lingkungan hidup adalah dengan gerakan penghijauan berupa penanaman pohon di lingkungan yang gersang. Bertolak dari seruan Paus Fransiskus melalui dokumen Laudato Si’, dan konsep ecoliteracy Fritjof Capra, penulis mengadakan pengabdian kepada masyarakat berupa kegiatan sosialisasi konsep ecoliteracy perspektif Laudato Si’ kepada umat Kapela Oemolo dan penerapannya dalam aksi penghijauan di Kapela Oemolo, Paroki Oecusse, Timor Leste. Metode yang dipakai adalah penuluhan yaitu pemberian pemahaman tentang pentingnya ekologi dan penanaman pohon di lingkungan Kapela Oemolo. Hasil yang dicapai adalah adanya pemahaman umat mengenai ekologi dan tindakan penghijauan yang akan dilanjutkan oleh umat dengan pemeliharaan pohon yang ditanam. Kesadaran ekologi ini diharapkan berkelanjutan sehingga makin banyak lahan kosong yang ditanami pepohonan

Protonation States of Remote Residues Affect Binding-Release Dynamics of the Ligand but not the Conformation of apo Ferric Binding Protein

We have studied the apo (Fe3+ free) form of periplasmic ferric binding protein (FbpA) under different conditions and we have monitored the changes in the binding and release dynamics of H2PO4- that acts as a synergistic anion in the presence of Fe3+. Our simulations predict a dissociation constant of 2.2$\pm$0.2 mM which is in remarkable agreement with the experimentally measured value of 2.3$\pm$0.3 mM under the same ionization strength and pH conditions. We apply perturbations relevant for changes in environmental conditions as (i) different values of ionic strength (IS), and (ii) protonation of a group of residues to mimic a different pH environment. Local perturbations are also studied by protonation or mutation of a site distal to the binding region that is known to mechanically manipulate the hinge-like motions of FbpA. We find that while the average conformation of the protein is intact in all simulations, the H2PO4- dynamics may be substantially altered by the changing conditions. In particular, the bound fraction which is 20$\%$ for the wild type system is increased to 50$\%$ with a D52A mutation/protonation and further to over 90$\%$ at the protonation conditions mimicking those at pH 5.5. The change in the dynamics is traced to the altered electrostatic distribution on the surface of the protein which in turn affects hydrogen bonding patterns at the active site. The observations are quantified by rigorous free energy calculations. Our results lend clues as to how the environment versus single residue perturbations may be utilized for regulation of binding modes in hFbpA systems in the absence of conformational changes.Comment: 26 pages, 4 figure

A systematic review on integration mechanisms in human and animal health surveillance systems with a view to addressing global health security threats

Lymphatic filariasis and onchocerciasis are neglected tropical diseases (NTDs) targeted for elimination by mass (antifilarial) drug administration. These drugs are predominantly active against the microfilarial progeny of adult worms. New drugs or combinations are needed to improve patient therapy and to enhance the effectiveness of interventions in persistent hotspots of transmission. Several therapies and regimens are currently in (pre-)clinical testing. Clinical trial simulators (CTSs) project patient outcomes to inform the design of clinical trials but have not been widely applied to NTDs, where their resource-saving payoffs could be highly beneficial. We demonstrate the utility of CTSs using our individual-based onchocerciasis transmission model (EPIONCHO-IBM) that projects trial outcomes of a hypothetical macrofilaricidal drug. We identify key design decisions that influence the power of clinical trials, including participant eligibility criteria and post-treatment follow-up times for measuring infection indicators. We discuss how CTSs help to inform target product profiles

Uganda's experience in Ebola virus disease outbreak preparedness, 2018-2019.

BACKGROUND: Since the declaration of the 10th Ebola Virus Disease (EVD) outbreak in DRC on 1st Aug 2018, several neighboring countries have been developing and implementing preparedness efforts to prevent EVD cross-border transmission to enable timely detection, investigation, and response in the event of a confirmed EVD outbreak in the country. We describe Uganda's experience in EVD preparedness. RESULTS: On 4 August 2018, the Uganda Ministry of Health (MoH) activated the Public Health Emergency Operations Centre (PHEOC) and the National Task Force (NTF) for public health emergencies to plan, guide, and coordinate EVD preparedness in the country. The NTF selected an Incident Management Team (IMT), constituting a National Rapid Response Team (NRRT) that supported activation of the District Task Forces (DTFs) and District Rapid Response Teams (DRRTs) that jointly assessed levels of preparedness in 30 designated high-risk districts representing category 1 (20 districts) and category 2 (10 districts). The MoH, with technical guidance from the World Health Organisation (WHO), led EVD preparedness activities and worked together with other ministries and partner organisations to enhance community-based surveillance systems, develop and disseminate risk communication messages, engage communities, reinforce EVD screening and infection prevention measures at Points of Entry (PoEs) and in high-risk health facilities, construct and equip EVD isolation and treatment units, and establish coordination and procurement mechanisms. CONCLUSION: As of 31 May 2019, there was no confirmed case of EVD as Uganda has continued to make significant and verifiable progress in EVD preparedness. There is a need to sustain these efforts, not only in EVD preparedness but also across the entire spectrum of a multi-hazard framework. These efforts strengthen country capacity and compel the country to avail resources for preparedness and management of incidents at the source while effectively cutting costs of using a "fire-fighting" approach during public health emergencies