129 research outputs found
Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
- Author
- Allen GI
- Amoroso N
- Anghel C
- Balagurusamy V
- Bare CJ
- Beaton D
- Bellotti R
- Bennett DA
- Boehme K
- Boutros PC
- Caberlotto L
- Caloian C
- Campbell F
- Chang YC
- Chen B
- Chen CY
- Chien TY
- Clark T
- Das S
- Davatzikos C
- Deng J
- Dillenberger D
- Dobson RJ
- Dong Q
- Doshi J
- Duma D
- Errico R
- Erus G
- Everett E
- Fardo DW
- Friend SH
- Fröhlich H
- Gan J
- Ghosh SS
- Glaab E
- Green RC
- Guan Y
- Hong MY
- Huang C
- Hwang J
- Ibrahim J
- Inglese P
- Jiang Q
- Katsumata Y
- Kauwe JS
- Klein A
- Kong D
- Krause R
- Lalonde E
- Lauria M
- Lee E
- Lin X
- Liu Z
- Livingstone J
- Logsdon BA
- Lovestone S
- Lyappan A
- Ma M
- Malhotra A
- Mangravite LM
- Maxwell TJ
- Merrill E
- Nagorski J
- Namasivayam A
- Narayan M
- Naz M
- Neto EC
- Newhouse SJ
- Norman TC
- Nurtdinov RN
- Oyang YJ
- Pawitan Y
- Peng S
- Peters MA
- Piccolo SR
- Praveen P
- Priami C
- Sabelnykova VY
- Senger P
- Shen X
- Simmons A
- Sotiras A
- St George-Hyslop P
- Stolovitzky G
- Tangaro S
- Tateo A
- Tung YA
- Tustison NJ
- Varol E
- Vradenburg G
- Weiner MW
- Xiao G
- Xie L
- Xie Y
- Xu J
- Yang H
- Zhan X
- Zhou Y
- Zhu F
- Zhu H
- Zhu S
- Publication venue
- 'Elsevier BV'
- Publication date
- 11/04/2016
- Field of study
Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance
Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma
- Author
- A Claperon
- A Claperon
- A Gentilini
- A Techasen
- A Techasen
- A Villanueva
- AE Sirica
- AEA Bergquist
- AFV Holczbauer
- AG Cox
- B Glimelius
- B Goeppert
- B Sripa
- BMY Fan
- BS Ding
- C Chuaysri
- C Raggi
- C Subimerb
- CD Fingas
- CK Ong
- CM Weisend
- D Hanahan
- D Malka
- D Yamada
- D Zhou
- DJ Murphy
- E Stocker
- EG Fritcher
- EG Huntzicker
- GA Michelotti
- GK Bonney
- GK Michalopoulos
- H Clevers
- H Hasita
- H Okabe
- H Okabe
- J Milano
- J Valle
- JB Andersen
- JC Mertens
- JM Banales
- K Kajiyama
- K Overturf
- K Yanger
- KP Lee
- L Boulter
- L Planas-Paz
- M Cadamuro
- M Ducreux
- M El Khatib
- M El Khatib
- M Fausther
- M Huch
- M Komuta
- M Lardelli
- M Swiderska-Syn
- MSB Komuta
- N Tokumoto
- P Beatus
- P Marti
- P Wang
- Q Gao
- R Carpentier
- R Espanol-Suner
- RV Guest
- RV Guest
- S Attia
- S Darwish Murad
- S Ohira
- S Rao
- S Sekiya
- S Sekiya
- S Zender
- SJ Bray
- SJ Lubner
- SL Zhou
- T Ikenoue
- T Oda
- T Okusaka
- T Zhan
- TG Bird
- TY Choi
- V Gebbia
- W Loilome
- WR Gordon
- WY Lu
- Y Kim
- YPA Zong
- ZD Burke
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/05/2017
- Field of study
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
- Author
- Alver M
- Amin N
- Arking DE
- Arnett DK
- Aschard H
- Aslibekyan S
- Ballantyne C
- Bartz TM
- Becker DM
- Bentley AR
- Bielak LF
- Boerwinkle E
- Boissel M
- Bonnefond A
- Bouchard C
- Bowden DW
- Brody JA
- Broeckel U
- Brown MR
- Campbell A
- Canouil M
- Chai JF
- Chai X
- Chasman DI
- Chen X
- Chen Y-DI
- Cheng C-Y
- Chitrala KN
- Christensen K
- Concas MP
- Cooper RS
- de Faire U
- de las Fuentes L
- de Mutsert R
- de Silva HJ
- de Vries PS
- Deary IJ
- Divers J
- Do A
- Dorajoo R
- Esko T
- Evans MK
- Faul JD
- Feitosa MF
- Fisher V
- Floyd JS
- Fornage M
- Forrester T
- Fox ER
- Franks PW
- Freedman BI
- Friedlander Y
- Froguel P
- Gao C
- Gauderman J
- Gieger C
- Girotto G
- Giulianini F
- Gu CC
- Gudnason V
- Guo X
- Hallmans G
- Harris SE
- Hartwig FP
- Hayward C
- He M
- Heikkinen S
- Heng C-K
- Homuth G
- Horimoto A
- Horta BL
- Hsu F-C
- Hunt S
- Ikram MA
- Jacobs DR
- Jonas JB
- Kardia SLR
- Kato N
- Kavousi M
- Khor CC
- Kilpeläinen TO
- Koh W-P
- Kolčić I
- Komulainen P
- Krieger JE
- Kühnel B
- Laguzzi F
- Lakka TA
- Langefeld CD
- Leander K
- Lehtimäki T
- Li X
- Liang J
- Lim E
- Liu C-T
- Liu J
- Liu K
- Liu Y
- Lohman K
- Lyytikäinen L-P
- Magnusson PKE
- Manichaikul AW
- Manning AK
- Marten J
- McKenzie CA
- Meitinger T
- Milaneschi Y
- Miller CL
- Mook-Kanamori DO
- Morrison AC
- Munroe PB
- Musani SK
- Mägi R
- Nauck M
- Nelson CP
- Nolte IM
- Noordam R
- North KE
- Ntalla I
- O’Connell JR
- Padmanabhan S
- Palmer ND
- Penninx B
- Pereira AC
- Perls T
- Peters A
- Peyser PA
- Polašek O
- Poveda A
- Province MM
- Psaty BM
- Raitakari OT
- Rankinen T
- Rao DC
- Rauramaa R
- Riaz M
- Rice K
- Rice TK
- Rich SS
- Richard MA
- Ridker PM
- Robino A
- Rotter JI
- Rudan I
- Sabanayagam C
- Samani NJ
- Schreiner PJ
- Schwander KL
- Shu X-O
- Sidney S
- Sim X
- Sims M
- Smith AV
- Smith BH
- Smith JA
- Snieder H
- Sofer T
- Spedicati B
- Starr JM
- Strauch K
- Sung YJ
- Tai ES
- Takeuchi F
- Taylor KD
- Tayo BO
- Tsai MY
- Uitterlinden AG
- van Dam RM
- van der Harst P
- van der Most PJ
- van Duijn CM
- van Heemst D
- Verweij N
- Vojinovic D
- Völzke H
- Wagenknecht LE
- Waldenberger M
- Wang Y-X
- Ware EB
- Wei W-B
- Weir DR
- Weiss S
- Wen W
- Wilson G
- Winkler TW
- Wojczynski MK
- Wong TY
- Wu T
- Xuan D
- Yanek LR
- Yao J
- Yu C
- Yuan J-M
- Zhan Y
- Zhao W
- Zheng W
- Zhu X
- Zonderman AB
- Publication venue
- Frontiers
- Publication date
- 20/11/2023
- Field of study
ICAR: endoscopic skull‐base surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- Al‐Mamgani A
- Al‐Mefty O
- Al‐Sheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
- Andrade NA
- Andrews JC
- Anik I
- Ansa B
- Ansari M
- Antonelli AR
- Arafah BM
- Arafah BM
- Arafah BM.
- Arai A
- Arat YO
- Arbolay OL
- Ardehali MM
- Armengot M
- Arnautovic KI
- Arrer E
- Arslan HH
- Aryan HE
- Asano S
- Askoxylakis V
- Astrup J
- Awad AJ
- Awad M
- Azad TD
- Aziz KM
- Babin E
- Bachmann G
- Back L
- Backlund EO.
- Baijal V
- Balaker AE
- Ballah D
- Balzer JR
- Banks CA
- Banu MA
- Banu MA
- Banuchi VE
- Barnes L
- Baser B
- Baskin DS
- Battaglia P
- Battaglia P
- Becker AM
- Beckhardt RN
- Bedi AD
- Bedrosian JC
- Bedrosian JC
- Beer‐Furlan A
- Beer‐Furlan A
- Beham A
- Bejjani GK
- Bell D
- Bell RB
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- Berdahl JP
- Berhouma M
- Berker M
- Berker M
- Berkmann S
- Berkmann S
- Berkmann S
- Bernal‐Sprekelsen M
- Bernal‐Sprekelsen M
- Bernat AL
- Bertrand B
- Bhasker S
- Bhatti SN
- Bidot S
- Bills DC
- Bishop JA
- Biswas D
- Black PM
- Bleier BS
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- Bleier BS
- Bleier BS
- Bloch C
- Bloch O
- Bly RA
- Boghani Z
- Bohman LE
- Bohman LE
- Bokhari AR
- Boling CC
- Bolzoni Villaret A
- Borg A
- Borghei P
- Boukheris H
- Brackmann DE
- Bradley PJ
- Branston NM
- Brastianos PK
- Bremer JW
- Bresson D
- Briet C
- Briggs RJ
- Brodie HA.
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- But‐Hadzic J
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- Caicedo‐Granados E
- Caldarelli M
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- Carter KB
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- Catapano G
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- Cebula H
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- Chaaban MR
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- Chabot JD
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- Chapurlat RD
- Charlett SD
- Chauvet D
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- Chen AM
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- Chen J
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- Chen ZY
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- Chi F
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- Chiu AG
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- Choby GW
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- Chowdhury FH
- Christopherson K
- Chung TK
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- Ciric I
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- Clemenza JW
- Clifford‐Jones RE
- Cloutier T
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- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
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- Abildgaard MH
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- Camara NO
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- Cayuela ML
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- Cecarini V
- Cecconi F
- Cechowska-Pasko M
- Cenci S
- Ceperuelo-Mallafré V
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- Cervia D
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- Chakrabarti O
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- Chen R-H
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- Chen W
- Chen W
- Chen X
- Chen X-M
- Chen X-W
- Chen Y
- Chen Y
- Chen Y
- Chen Y-G
- Chen Y-J
- Chen Y-Q
- Chen Z
- Chen Z
- Chen Z
- Chen Z-H
- Chen ZJ
- Chen ZS
- Cheng H
- Cheng J
- Cheng S-Y
- Cheng W
- Cheng X
- Cheng X-T
- Cheng Y
- Cheng Z
- Cheong H
- Cheong JK
- Chernyak BV
- Cherry S
- Cheung CFR
- Cheung CHA
- Cheung K-H
- Chevet E
- Chi RJ
- Chiang AKS
- Chiaradonna F
- Chiarelli R
- Chiariello M
- Chica N
- Chiocca S
- Chiong M
- Chiou S-H
- Chiramel AI
- Chiurchiù V
- Cho D-H
- Choe S-K
- Choi AMK
- Choi ME
- Choudhury KR
- Chow NS
- Chu CT
- Chua JJE
- Chua JP
- Chung H
- Chung KP
- Chung S
- Chung S-H
- Chung Y-L
- Cianfanelli V
- Ciechomska IA
- Cifuentes M
- Cinque L
- Cirak S
- Cirone M
- Clague MJ
- Clarke R
- Clementi E
- Coccia EM
- Codogno P
- Cohen E
- Cohen MM
- Colasanti T
- Colasuonno F
- Colbert RA
- Colell A
- Coll NS
- Collins MO
- Colombo MI
- Colón-Ramos DA
- Combaret L
- Comincini S
- Cominetti MR
- Consiglio A
- Conte A
- Conti F
- Contu VR
- Cookson MR
- Coombs KM
- Coppens I
- Corasaniti MT
- Cordes N
- Corkery DP
- Cortese K
- Costa MDC
- Costantino S
- Costelli P
- Coto-Montes A
- Crack PJ
- Crespo JL
- Criollo A
- Crippa V
- Cristofani R
- Csizmadia T
- Cuadrado A
- Cui B
- Cui J
- Cui Y
- Cui Y
- Culetto E
- Cumino AC
- Cybulsky AV
- Czaja MJ
- Czuczwar SJ
- D'Adamo S
- D'Amelio M
- D'Arcangelo D
- D'Lugos AC
- D'Orazi G
- da Silva JA
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- Dagda RK
- Dagdas Y
- Daglia M
- Dai X
- Dai Y
- Dai Y
- Dal Col J
- Dalhaimer P
- Dalla Valle L
- Dallenga T
- Dalmasso G
- Damme M
- Dando I
- Dantuma NP
- Darling AL
- Das H
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- Dash S
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- Dauphinee AN
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- Davis RJ
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- Dayalan Naidu S
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- De Felice F
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- De Leonibus C
- de Mattos Barbosa MG
- De Meyer GRY
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- DeBosch BJ
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- Delbridge LMD
- Delorme-Axford E
- Delpino MV
- Demarchi F
- Dembitz V
- Demers ND
- Deng H
- Deng Z
- Dengjel J
- Dent P
- Denton D
- DePamphilis ML
- Der CJ
- Deretic V
- Descoteaux A
- Devis L
- Devkota S
- Devuyst O
- Dewson G
- Dharmasivam M
- Dhiman R
- di Bernardo D
- Di Cristina M
- Di Domenico F
- Di Fazio P
- Di Fonzo A
- Di Guardo G
- Di Guglielmo GM
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- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment
- Author
- A Loytynoja
- A Sluijs
- A Vanhoutteghem
- AFA Smit
- C Barbraud
- C Dawson
- C Notredame
- C Ruhrberg
- DB Thomas
- DG Ainley
- DO Schreiweis
- DT Ksepka
- E Bonnet
- ED Jarvis
- EJ Woehler
- EP Nawrocki
- F Gill
- G Benson
- G Parra
- G Zhang
- G Zhang
- G Zhang
- GJ Wilson
- H Li
- J Forcada
- J Jurka
- J Ruan
- J Zachos
- JA Blake
- JG Sivak
- JG Sivak
- JK Bowmaker
- JL Kelley
- JRE Taylor
- K Visser
- L Rickman
- LE Lisiecki
- LW Hillier
- M Alten
- M Watson
- ME Katz
- MJ Greenwold
- MJ Greenwold
- MJ Greenwold
- N Chen
- PA Ritchie
- PGH Frost
- PP Gardner
- PU Clark
- Q Cai
- R Goldsmith
- R Groscolas
- R Groscolas
- R Li
- R Li
- R Li
- RA Dalloul
- RH Sawyer
- RIC Spearman
- RJ Raikow
- RL Ge
- RS Harris
- RS Piezzi
- S Griffiths-Jones
- S Janssen
- S Jenouvrier
- S Jenouvrier
- S Liu
- S Subramanian
- S Thatje
- SF Altschul
- T De Bie
- T Okano
- TD Williams
- TM Lowe
- TY Chen
- VL Ruiz-Perez
- W Meister
- WC Warren
- WJ Kent
- WM O'Guin
- WR Pearson
- X Zhan
- Y Cherel
- Y Choi
- YI Li
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND: Penguins are flightless aquatic birds widely distributed in the Southern Hemisphere. The distinctive morphological and physiological features of penguins allow them to live an aquatic life, and some of them have successfully adapted to the hostile environments in Antarctica. To study the phylogenetic and population history of penguins and the molecular basis of their adaptations to Antarctica, we sequenced the genomes of the two Antarctic dwelling penguin species, the Adélie penguin [Pygoscelis adeliae] and emperor penguin [Aptenodytes forsteri]. RESULTS: Phylogenetic dating suggests that early penguins arose ~60 million years ago, coinciding with a period of global warming. Analysis of effective population sizes reveals that the two penguin species experienced population expansions from ~1 million years ago to ~100 thousand years ago, but responded differently to the climatic cooling of the last glacial period. Comparative genomic analyses with other available avian genomes identified molecular changes in genes related to epidermal structure, phototransduction, lipid metabolism, and forelimb morphology. CONCLUSIONS: Our sequencing and initial analyses of the first two penguin genomes provide insights into the timing of penguin origin, fluctuations in effective population sizes of the two penguin species over the past 10 million years, and the potential associations between these biological patterns and global climate change. The molecular changes compared with other avian genomes reflect both shared and diverse adaptations of the two penguin species to the Antarctic environment
Evidence that the Ceratobasidium-like white-thread blight and black rot fungal pathogens from persimmon and tea crops in the Brazilian Atlantic Forest agroecosystem are two distinct phylospecies
- Author
- Altschul S
- Aylor DL
- Baker CJ
- Barua D
- Beerli P
- Benchimol RL
- Bernardes-de-Assis J
- Bucheli E
- Carbone I
- Carlisle D
- Cavalcante M
- Ceresini PC
- Ceresini PC
- Ciampi MB
- Clark-Walker GD
- Clement M
- Costa-Souza E
- Couch BC
- Couch BC
- Donk M
- Drummond AJ
- Drummond AJ
- Edson L. Furtado
- Elaine Costa-Souza
- Fawcett GL
- Forget L
- Fu YX
- Furtado E
- Ganley ARD
- Gasparotto L
- Ghimire SR
- Gonzalez D
- Griffiths RC
- Griffiths RC
- Gutierrez W
- Herr L
- Hudson R
- Huelsenbeck JP
- Huyse T
- James TY
- Kasuga T
- Kretzer AM
- Kuhner MK
- Kuhner MK
- Lourd M
- Láday M
- Marcello Zala
- McDonald BA
- McDonald BA
- Moncalvo J-M
- Nilton L. Souza
- Paquin B
- Paquin B
- Paulo C. Ceresini
- Pereira RCA
- Pereira RCA
- Posada D
- Posada D
- Price EW
- Roberts P
- Rogers D
- Rosseti V
- Rozas J
- Sneh B
- Sommerhalder RJ
- Stukenbrock EH
- Swofford DL
- Tajima F
- Talbot P
- Templeton AR
- Thompson J
- Thompson J
- Tims EC
- Venkatarayan S
- White TJ
- Wight W
- Wight W
- Xu J
- Zaffarano PL
- Zhan J
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Encoder-decoder with dense dilated spatial pyramid pooling for prostate MR images segmentation
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Differing epidemiological dynamics of influenza B virus lineages in Guangzhou, southern China, 2009-2010
- Publication venue
- 'American Society for Microbiology'
- Publication date
- 01/01/2013
- Field of study
The epidemiological and evolutionary dynamics of the two cocirculating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009 to 2010 and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that (i) the Yamagata lineage infected older people than either Victoria lineage and (ii) fewer upper respiratory tract infections were caused by the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality and has implications for vaccination policy in southern China.link_to_subscribed_fulltex
Investigating the interaction between internal structural changes and water sorption of MDF and OSB using X-ray computed tomography
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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