45 research outputs found
Isolation of Candida Species from the Tongues of Young Subjects
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Characteristics of Health-related Concepts of Students Who Aim to Work in the Childcare Field before Taking Childcare âHealthâ Classes
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Relevance between âPhysical Bodyâ and âHealthâ Field of Childcare Contents in Froebelâs âEdsucation of the Human Beingâ (4th report) : by Focusing on âSection 3 Human Being as a Boyâ
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Issues of Health Education in Early Childhood and Formation of Young Children's Body Image
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Results of Musculoskeletal Examinations in Elementary School Students and its Challenges
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The Evidence-based Physical Assessment for headache by Yogo Teacherâs practices
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Isolation of Candida Species from the Tongues of Young Subjects
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Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent
Shell thickness determines the acoustic response of polymer-based perfluorooctyl bromide (PFOB) nanocapsule ultrasound contrast agents. PEGylation provides stealth property and arms for targeting moieties. We investigated a modulation in the polymer formulation of carboxy-terminated poly(D,L-lactide-co-glycolide) (PLGA) and poly(D,L-lactide-co-glycolide)-block-polyethylene glycol (PLGA-b-PEG) to produce thin-shelled PFOB nanocapsules while keeping its echogenicity, stealth property, and active targeting potential. Polymer formulation contains 40% PLGA-PEG that yields the PEGylated PFOB nanocapsules of approximately 150ânm size with average thickness-to-radius ratio down to 0.15, which adequately hindered phagocytosis. Functionalization with antibody enables in vitro tumor-specific targeting. Despite the acoustic response improvement, the in vivo tumor accumulation was inadequate to generate an observable acoustic response to the ultrasound power at the clinical level. The use of PLGA and PLGA-PEG polymer blend allows the production of thin-shelled PFOB nanocapsules with echogenicity improvement while maintaining its potential for specific targeting