Evidence for the h_b(1P) meson in the decay Upsilon(3S) --> pi0 h_b(1P)

Using a sample of 122 million Upsilon(3S) events recorded with the BaBar detector at the PEP-II asymmetric-energy e+e- collider at SLAC, we search for the $h_b(1P)$ spin-singlet partner of the P-wave chi_{bJ}(1P) states in the sequential decay Upsilon(3S) --> pi0 h_b(1P), h_b(1P) --> gamma eta_b(1S). We observe an excess of events above background in the distribution of the recoil mass against the pi0 at mass 9902 +/- 4(stat.) +/- 2(syst.) MeV/c^2. The width of the observed signal is consistent with experimental resolution, and its significance is 3.1sigma, including systematic uncertainties. We obtain the value (4.3 +/- 1.1(stat.) +/- 0.9(syst.)) x 10^{-4} for the product branching fraction BF(Upsilon(3S)-->pi0 h_b) x BF(h_b-->gamma eta_b).Comment: 8 pages, 4 postscript figures, submitted to Phys. Rev. D (Rapid Communications

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns

Should the dosage of controlled-release oxycodone in advanced cancer be modified on the basis of patient characteristics?

This study aimed to investigate whether the characteristics of patients with advanced cancer explain the variability in oxycodone clearance, with the potential for this information to determine maintenance dosing

Modelling of future mass balance changes of Norwegian glaciers by application of a dynamical–statistical model

The long-term behaviour of Norwegian glaciers is reflected by the long mass-balance records provided by the Norwegian Water Resources and Energy Directorate. These show positive annual mass balances in the 1980s and 1990s at maritime glaciers followed by rapid mass loss since 2000. This study assesses the influence of various atmospheric variables on mass changes of selected Norwegian glaciers by correlation- and cross-validated stepwise multiple regression analyses. The atmospheric variables are constructed from reanalyses by the National Centers for Environmental Prediction and the European Centre for Medium-Range Weather Forecasts. Transfer functions determined by the multiple regression are applied to predictors derived from a multi-model ensemble of climate projections to estimate future mass-balance changes until 2100. The statistical relationship to the North Atlantic Oscillation (NAO), the strongest predictor, is highest for maritime glaciers and less for more continental ones. The mass surplus in the 1980s and 1990s can be attributed to a strong NAO phase and lower air temperatures during the ablation season. The mass loss since 2000 can be explained by an increase of summer air temperatures and a slight weakening of the NAO. From 2000 to 2100 the statistical model predicts predicts changes for glaciers in more continental settings of c. −20 m w.e. (water equivalent) or 0.2 m w.e./a. The corresponding range for their more maritime counterparts is −0.5 to +0.2 m w.e./a. Results from Bayesian classification of observed atmospheric states associated with high melt or high accumulation in the past into different simulated climates in the future suggest that climatic conditions towards the end of the twenty-first century favour less winterly accumulation and more ablation in summer. The posterior probabilities for high accumulation at the end of the twenty-first century are typically 1.5–3 times lower than in the twentieth century while the posterior probabilities for high melt are often 1.5–3 times higher at the end of the twenty-first century than in the twentieth and early twenty-first century