Learning the Fundamentals from Hands-on Learning

The projects featured in this piece represent the notion of design as an act of thinking-through-making. Through studies in design principles, craftsmanship, exercises, and projects, students engaged in hands-on learning, which included drawings, model-making, and producing artifacts. Fundamentals of Design Thinking: Architecture Majors Learning Community, Prof. Bronne Dytoc, Prof. Mine H. Hashas-Degertekin, Prof. Zamila Karimi, Prof. Marietta Monaghan, Prof. Willie Pittman, and Prof. Arief Setiawa

Probing the Spiral Magnetic Phase in 6 nm Textured Erbium using Polarised Neutron Reflectometry

We characterise the magnetic state of highly-textured, sputter deposited erbium for a film of thickness 6 nm. Using polarised neutron reflectometry it is found the film has a high degree of magnetic disorder, and we present some evidence that the films’ local magnetic state is consistent with bulk-like spiral magnetism. This, combined with complementary characterisation techniques, show that thin film erbium is a strong candidate material for incorporation into device structures

Erosion and Accretion on a Mudflat: The Importance of Very Shallow-Water Effects

Understanding erosion and accretion dynamics during an entire tidal cycle is important for assessing their impacts on the habitats of biological communities and the long‐term morphological evolution of intertidal mudflats. However, previous studies often omitted erosion and accretion during very shallow‐water stages (VSWS, water depths 0.2 m (i.e., probe submerged) are considered. These findings suggest that the magnitude of bed‐level changes during VSWS should not be neglected when modeling morphodynamic processes. Our results are useful in understanding the mechanisms of micro‐topography formation and destruction that often occur at VSWS, and also improve our understanding and modeling ability of coastal morphological changes

Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

This is the final version. Available on open access from Elsevier via the DOI in this recordBACKGROUND AND AIMS: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes. METHODS AND RESULTS: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men. CONCLUSIONS: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.National Institute for Health Research (NIHR

Metabolic, hygric and ventilatory physiology of a hypermetabolic marsupial, the honey possum (Tarsipes rostratus)

The honey possum is the only non-volant mammal to feed exclusively on a diet of nectar and pollen. Like other mammalian and avian nectarivores, previous studies indicated that the honey possum's basal metabolic rate was higher than predicted for a marsupial of equivalent body mass. However, these early measurements have been questioned. We re-examined the basal metabolic rate (2.52 +/- A 0.222 ml O(2) g(-1) h(-1)) of the honey possum and confirm that it is indeed higher (162%) than predicted for other marsupials both before and after accounting for phylogenetic history. This, together with its small body mass (5.4 +/- A 0.14 g; 1.3% of that predicted by phylogeny) may be attributed to its nectarivorous diet and mesic distribution. Its high-basal metabolic rate is associated with a high-standard body temperature (36.6 +/- A 0.48A degrees C) and oxygen extraction (19.4%), but interestingly the honey possum has a high point of relative water economy (17.0A degrees C) and its standard evaporative water loss (4.33 +/- A 0.394 mg H(2)O g(-1) h(-1)) is not elevated above that of other marsupials, despite its mesic habitat and high dietary water intake.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Results of a feasibility randomised controlled trial (RCT) for WATCH IT: a programme for obese children and adolescents

Background: In the evaluation of childhood obesity interventions, few researchers undertake a rigorous feasibility stage in which the design and procedures of the evaluation process are examined. Consequently, phase III studies often demonstrate methodological weaknesses. Purpose: Our aim was to conduct a feasibility trial of the evaluation of WATCH IT, a community obesity intervention for children and adolescents. We sought to determine an achievable recruitment rate; acceptability of randomisation, assessment procedures, and dropout rate; optimal outcome measures for the definitive trial; and a robust sample size calculation. Method: Our goal was to recruit 70 participants over 6 months, randomise them to intervention or control group, and retain participation for 12 months. Assessments were taken prior to randomisation and after 6 and 12 months. Procedures mirrored those intended for a full-scale trial, but multiple measures of similar outcomes were included as a means to determine those most appropriate for future research. Acceptability of the research and impact of the research on the programme were ascertained through interviewing participants and staff. Results: We recruited 70 participants and found that randomisation and data collection procedures were acceptable. Self-referral (via media promotion) was more effective than professional referral. Blinding of assessors was sustained to a reasonable degree, and optimal outcome measures for a full-scale trial were identified. Estimated sample size was significantly greater than sample sized reported in published trials. There was some negative impact on the existing programme as a result of the research, a lesson for designers of future trials. Limitations: We successfully recruited socially disadvantaged families, but the majority of families were of White British nationality. The composition of the participants was an added valuable lesson, suggesting that recruitment strategies to obtain a more heterogeneous ethnic sample warrant consideration in future research. Conclusions: This study provided us with confidence that we can run a phase III multi-centre trial to test the effectiveness of WATCH IT. Importantly, it was invaluable in informing the design not only of that trial but also of future evaluations of childhood obesity treatment interventions

Potentiation of photodynamic therapy of cancer by complement: the effect of γ-inulin

Host response elicited by photodynamic therapy (PDT) of cancerous lesions is a critical contributor to the clinical outcome, and complement system has emerged as its important element. Amplification of complement action was shown to improve tumour PDT response. In search of a clinically relevant complement activator for use as a PDT adjuvant, this study focused on γ-inulin and examined its effects on PDT response of mouse tumours. Intralesional γ-inulin (0.1 mg mouse−1) delivered immediately after PDT rivaled zymosan (potent classical complement activator) in delaying the recurrence of B16BL6 melanomas. This effect of γ-inulin was further enhanced by IFN-γ pretreatment. Tumour C3 protein levels, already elevated after individual PDT or γ-inulin treatments, increased much higher after their combination. With fibrosarcomas MCA205 and FsaR, adjuvant γ-inulin proved highly effective in reducing recurrence rates following PDT using four different photosensitisers (BPD, ce6, Photofrin, and mTHPC). At 3 days after PDT plus γ-inulin treatment, over 50% of cells found at the tumour site were CTLs engaged in killing specific targets via perforin–granzyme pathway. This study demonstrates that γ-inulin is highly effective PDT adjuvant and suggests that by amplifying the activation of complement system, this agent potentiates the development of CTL-mediated immunity against PDT-treated tumours

Positronium emission from MgO smoke nanocrystals

We report experiments in which positronium (Ps) atoms were created in a thick layer of MgO smoke powder deposited on a thin silicon nitride substrate. The experimental arrangement was such that a positron beam could be implanted directly into the top of the MgO layer or be transmitted through the substrate, allowing Ps to be produced within ≈100 nm or 30 μm of the powder-vacuum interface. The transverse kinetic energy of Ps atoms emitted into vacuum was measured via the Doppler broadening of 13 S1 2 3PJ transitions, and found to be Ex ≈ 350 meV, regardless of how far Ps atoms had traveled through the powder layer. Our data are not consistent with the model in which energetic Ps atoms emitted into the internal free volume of a porous material are cooled via multiple surface collisions, and instead indicate that in nanocrystals lower energy Ps is generated, with negligible subsequent cooling in the large open volumes of the powder. Our experiments also demonstrate that SiN substrates coated with MgO smoke can provide a simple and inexpensive method for producing Ps transmission targets

Quantifying the interplay of experimental constraints in analyses of parton distributions

Parton distribution functions (PDFs) play a central role in calculations for the LHC. To gain a deeper understanding of the emergence and interplay of constraints on the PDFs in the global QCD analyses, it is important to examine the relative significance and mutual compatibility of the experimental datasets included in the PDF fits. Toward this goal, we discuss the L2 sensitivity, a convenient statistical indicator for exploring the statistical pulls of individual datasets on the best-fit PDFs and identifying tensions between competing datasets. Unlike the Lagrange multiplier method, the L2 sensitivity can be quickly computed for a range of PDFs and momentum fractions using the published Hessian error sets. We employ the L2 sensitivity as a common metric to study the relative importance of datasets in the recent ATLAS, CTEQ-TEA, MSHT, and reduced PDF4LHC21 PDF analyses at next-to-next-to-leading-order and approximate next-to-next-to-next-to-leading-order. We illustrate how this method can aid the users of PDFs to identify datasets that are important for a PDF at a given kinematic point, to study quark flavor composition and other detailed features of the PDFs, and to compare the data pulls on the PDFs for various perturbative orders and functional forms. We also address the feasibility of computing the sensitivities using Monte Carlo error PDFs. Together with the article, we present a companion interactive website with a large collection of plotted L2 sensitivities for eight recent PDF releases and a C++ program to plot the L2 sensitivities