177 research outputs found
Potential instability of gas hydrates along the chilean margin due to ocean warming
In the last few years, interest in the offshore Chilean margin has increased rapidly due to the presence of gas hydrates. We have modelled the gas hydrate stability zone off Chilean shores (from 33\ub0 S to 46\ub0 S) using a steady state approach to evaluate the effects of climate change on gas hydrate stability. Present day conditions were modelled using published literature and compared with available measurements. Then, we simulated the effects of climate change on gas hydrate stability in 50 and 100 years on the basis of Intergovernmental Panel on Climate Change and National Aeronautics and Space Administration forecasts. An increase in temperature might cause the dissociation of gas hydrate that could strongly affect gas hydrate stability. Moreover, we found that the high seismicity of this area could have a strong effect on gas hydrate stability. Clearly, the Chilean margin should be considered as a natural laboratory for understanding the relationship between gas hydrate systems and complex natural phenomena, such as climate change, slope stability and earthquakes
Observation of the Main Natural Parameters Influencing the Formation of Gas Hydrates
Chemical composition in seawater of marine sediments, as well as the physical properties and chemical composition of soils, influence the phase behavior of natural gas hydrate by disturbing the hydrogen bond network in the water-rich phase before hydrate formation. In this article, some marine sediments samples, collected in National Antarctic Museum in Trieste, were analyzed and properties such as pH, conductivity, salinity, and concentration of main elements of water present in the sediments are reported. The results, obtained by inductively coupled plasma-mass spectrometry (ICP-MS) and ion chromatography (IC) analysis, show that the more abundant cation is sodium and, present in smaller quantities, but not negligible, are calcium, potassium, and magnesium, while the more abundant anion is chloride and sulfate is also appreciable. These results were successively used to determine the thermodynamic parameters and the effect on salinity of water on hydrates’ formation. Then, hydrate formation was experimentally tested using a small-scale apparatus, in the presence of two different porous media: a pure silica sand and a silica-based natural sand, coming from the Mediterranean seafloor. The results proved how the presence of further compounds, rather than silicon, as well as the heterogeneous grainsize and porosity, made this sand a weak thermodynamic and a strong kinetic inhibitor for the hydrate formation process
Basal and Frontal Accretion Processes versus BSR Characteristics along the Chilean Margin
Multichannel seismic reflection data recorded between Itata (36°S) and Coyhaique offshores (43°S) were processed to obtain seismic images. Analysis of the seismic profiles revealed that weak and discontinuous bottom simulating reflectors were associated to basal accretion processes, while strong and continuous bottom simulating reflectors were associated to frontal accretion processes. This can be explained considering that during basal accretion processes, extensional tectonic movements due to uplifting can favour fluid escapes giving origin to weaker and most discontinuous bottom simulating reflectors. During frontal accretion processes (folding and thrusting), high fluid circulation and stable tectonic conditions however can be responsible of stronger and most continuous bottom simulating reflectors. Along the Arauco-Valdivia offshores, steep accretionary prisms, normal faults, slope basins, and thicker underplated sediment bed were associated to basal accretion, while along the Itata, Chiloe and Coyhaique offshores, small accretionary prisms, folding, and thinner underplated sediment bed were associated to frontal accretion
Evaluation of non-chemical seed treatment methods for the control of Alternaria dauci and A. radicina on carrot seeds
The current study was initiated to evaluate the efficacy of physical methods (hot water, aerated steam, electron treatment) and agents of natural origin (resistance inducers, plant derived products, micro-organisms) as seed treatments of carrots for control of Alternaria dauci and A. radicina. Control of both Alternaria species by seed treatment with the resistance inducers was generally poor. Results were also not satisfactory with most of the formulated commercial micro-organism preparations. Based on the average of five field trials, one of these, BA 2552 (Pseudomonas chlororaphis), provided a low but significant increase in plant stand. Among the experimental micro-organisms, the best results were obtained with Pseudomonas sp. strain MF 416 and Clonostachys rosea strain IK726. A similar level of efficacy was provided by seed treatment with an emulsion (1%) of thyme oil in water. Good and consistent control was generally achieved with the physical methods aerated steam, hot water and electron treatment. Aerated steam treatment was, apart from the thiram-containing chemical standard, the best single treatment, and its performance may at least partially be due to extensive pre-testing, resulting in dosages optimally adapted to the respective seed lot. In some of the experiments the effect of the hot water treatment, which was tested at a fixed, not specifically adapted dosage, was significantly improved when combined with a Pseudomonas sp. MF 416 or C. rosea IK726 treatment. The results are discussed in relation to the outcome of experiments in which the same seed treatment methods and agents were tested in other seed-borne vegetable pathosystems
STOVE: Seed treatments for organic vegetable production
The aim of the EU-financed research project „STOVE“ (Seed Treatments for Organic Vegetable Production) is to evaluate different methods potentially suited for seed treatment of vegetables in organic farming regarding their efficacy, to optimise these methods, and where feasible to combine them with each other. Scientists from seven European research institutions and a producer of organic vegetable seeds carry out the project
A crustal seismic profile across Sicily
A crustal reflection seismic profile, more than 100 km long, was recorded across central Sicily, from the
Tyrrhenian shore to the Sicily Channel, to understand the deep structures and the collision mechanisms
between Europe and Africa and the subsequent geodynamic evolution. The profile was acquired using
explosive sources and 240 active channels recorded by a Sercel 408-XL, 24 bits A/D converter, with a 12 km
spread and a 24-fold coverage.
The data were processed following a non-conventional procedure in order to preserve the relative
amplitudes of the reflections and to better investigate the Sicily deep structures down to the Moho. The main
highlighted structures are the dramatic flexure of the Iblean crust, the huge, deeper than expected, trough of
Caltanissetta consisting of deep seated thrusts and nappes, and the imbricate thrust system of rigid bodies
characterizing the northern Maghrebian chain. We designed an ad hoc acquisition and processing in order to
highlight these main geological features in the seismic stacked section. Moreover, the deepest parts of the
Caltanissetta trough are imaged for the first time, and its bottom is now fixed at more than 7 s TWT. The
giant crustal wedge flexuring the Iblean foreland and the Moho geometries are examinated
Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase
Estrogen deficiency derived from inhibition of estrogen biosynthesis is a typical condition of postmenopausal women and breast cancer (BCs) patients undergoing antihormone therapy. The ensuing increase in aldosterone levels is considered to be the major cause for cardiovascular diseases (CVDs) affecting these patients. Since estrogen biosynthesis is regulated by aromatase (CYP19A1), and aldosterone biosynthesis is modulated by aldosterone synthase (CYP11B2), a dual inhibitor would allow the treatment of BC while reducing the cardiovascular risks typical of these patients. Moreover, this strategy would help overcome some of the disadvantages often observed in single-target or combination therapies. Following an in-depth analysis of a library of synthesized benzylimidazole derivatives, compound X21 was found to be a potent and selective dual inhibitor of aromatase and aldosterone synthase, with IC50 values of 2.3 and 29 nM, respectively. Remarkably, the compound showed high selectivity with respect to 11β-hydroxylase (CYP11B1), as well as CYP3A4 and CYP1A2. When tested in cells, X21 showed potent antiproliferative activity against BC cell lines, particularly against the ER+ MCF-7 cells (IC50 of 0.26 ± 0.03 μM at 72 h), and a remarkable pro-apoptotic effect. In addition, the compound significantly inhibited mTOR phosphorylation at its IC50 concentration, thereby negatively modulating the PI3K/Akt/mTOR axis, which represents an escape for the dependency from ER signaling in BC cells. The compound was further investigated for cytotoxicity on normal cells and potential cardiotoxicity against hERG and Nav1.5 ion channels, demonstrating a safe biological profile. Overall, these assays demonstrated that the compound is potent and safe, thus constituting an excellent candidate for further evaluation
Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study.
The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-centre observational study with prospective follow-up of 414 patients.
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