21,662 research outputs found
Study on utilization of advanced composites in fuselage structures of large transports
The potential for utilizing advanced composites in fuselage structures of large transports was assessed. Six fuselage design concepts were selected and evaluated in terms of structural performance, weight, and manufacturing development and costs. Two concepts were selected that merit further consideration for composite fuselage application. These concepts are: (1) a full depth honeycomb design with no stringers, and (2) an I section stringer stiffened laminate skin design. Weight reductions due to applying composites to the fuselages of commercial and military transports were calculated. The benefits of applying composites to a fleet of military transports were determined. Significant technology issues pertinent to composite fuselage structures were identified and evaluated. Program plans for resolving the technology issues were developed
The effects of reinforcement interval on the acquisition of paired-associate responses
Effects of reinforcement interval on acquisition of paired-associate response
Velocity, energy and helicity of vortex knots and unknots
In this paper we determine the velocity, the energy and estimate writhe and
twist helicity contributions of vortex filaments in the shape of torus knots
and unknots (toroidal and poloidal coils) in a perfect fluid. Calculations are
performed by numerical integration of the Biot-Savart law. Vortex complexity is
parametrized by the winding number , given by the ratio of the number of
meridian wraps to that of the longitudinal wraps. We find that for vortex
knots and toroidal coils move faster and carry more energy than a reference
vortex ring of same size and circulation, whereas for knots and poloidal
coils have approximately same speed and energy of the reference vortex ring.
Helicity is dominated by the writhe contribution. Finally, we confirm the
stabilizing effect of the Biot-Savart law for all knots and unknots tested,
that are found to be structurally stable over a distance of several diameters.
Our results also apply to quantized vortices in superfluid He.Comment: 17 pages, 8 figures, 2 table
Development of pressure containment and damage tolerance technology for composite fuselage structures in large transport aircraft
NASA sponsored composites research and development programs were set in place to develop the critical engineering technologies in large transport aircraft structures. This NASA-Boeing program focused on the critical issues of damage tolerance and pressure containment generic to the fuselage structure of large pressurized aircraft. Skin-stringer and honeycomb sandwich composite fuselage shell designs were evaluated to resolve these issues. Analyses were developed to model the structural response of the fuselage shell designs, and a development test program evaluated the selected design configurations to appropriate load conditions
Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline
Rationale:
Members of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.
Objective:
In the current study, we test the hypothesis that reduced MKK7 expression is sufficient to cause cognitive impairment.
Methods:
Attentional function in mice haploinsufficient for Map2k7 (Map2k7+/− mice) was investigated using the five-choice serial reaction time task (5-CSRTT).
Results:
Once stable performance had been achieved, Map2k7+/− mice showed a distinctive attentional deficit, in the form of an increased number of missed responses, accompanied by a more pronounced decrement in performance over time and elevated intra-individual reaction time variability. When performance was reassessed after administration of minocycline—a tetracycline antibiotic currently showing promise for the improvement of attentional deficits in patients with schizophrenia—signs of improvement in attentional performance were detected.
Conclusions:
Overall, Map2k7 haploinsufficiency causes a distinctive pattern of cognitive impairment strongly suggestive of an inability to sustain attention, in accordance with those seen in psychiatric patients carrying out similar tasks. This may be important for understanding the mechanisms of cognitive dysfunction in clinical populations and highlights the possibility of treating some of these deficits with minocycline
High brightness Yb:YAG planar waveguide laser with an unstable resonator formed with a novel laser-machined, toroidal mode-selective mirror
Mode-selective toroidal mirrors for unstable resonator planar waveguide and thin slab solid-state lasers
Calculation of Elastic Green's Functions for Lattices with Cavities
In this Brief Report, we present an algorithm for calculating the elastic
Lattice Greens Function of a regular lattice, in which defects are created by
removing lattice points. The method is computationally efficient, since the
required matrix operations are on matrices that scale with the size of the
defect subspace, and not with the size of the full lattice. This method allows
the treatment of force fields with multi-atom interactions.Comment: 3 pages. RevTeX, using epsfig.sty. One figur
Intrinsic Periodicity of Time and Non-maximal Entropy of Universe
The universe is certainly not yet in total thermodynamical equilibrium,so
clearly some law telling about special initial conditions is needed. A universe
or a system imposed to behave periodically gets thereby required ``initial
conditions". Those initial conditions will \underline{not} look like having
already suffered the heat death, i.e. obtained the maximal entropy, like a
random state. The intrinsic periodicity explains successfully why entropy is
not maximal, but fails phenomenologically by leading to a
\underline{constant}entropy.Comment: 8 page
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