258 research outputs found

    Gratitude for Better or Worse: Differential Predictors and Affective Outcomes of State Gratitude in Positive and Negative Contexts

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    Whereas past studies primarily examined state-level gratitude measured across long periods of time and in the context of positive events, this study assessed situational predictors of state gratitude and its affective outcomes in the context of specific positive and negative naturalistic events. Across seven weeks, 147 undergraduates recorded best and worst weekly events, depressive symptoms, as well as gratitude and positive affect (PA) anchored to those events. Independent raters coded events as dependent or independent of participants’ agency and interpersonal or noninterpersonal. Multilevel models showed there was a significant interaction between agency and interpersonal status for positive events, and simple effects tests indicated participants reported higher levels of gratitude for independent-interpersonal events compared to other potential event types. Unexpectedly, participants also reported higher gratitude for dependent events if they were interpersonal in nature. Negative event-anchored state gratitude was also higher for interpersonal events as indicated by a significant main effect. Lastly, within-person variability in event-anchored state gratitude was associated with higher state PA following both best and worst events, but only state gratitude anchored to best events was related to lower weekly depressive symptoms. Overall, results demonstrated that naturally occurring state gratitude for specific events was differentially impacted by situational factors, and that within-person variability in gratitude following both positive and negative events is related to positive affective outcomes

    Paleolimnological Evidence of Terrestrial and Lacustrine Environmental Change in Response to European Settlement of the Red River Valley, Manitoba and North Dakota

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    Limnological and terrestrial changes in three floodplain lakes are correlated with settlement of the Red River valley in Manitoba and North Dakota. Distinctive pollen, diatom and thecamoebian assemblages provide proxy evidence of the ecological changes from pre- to post-settlement periods in Horseshoe Lake, Lake Louise and Salt Lake. In the pre-settlement period (Zone I), prior to ~1812, grass and Quercus pollen dominate and are indicative of a tall grass prairie-oak riparian forest ecosystem. Diatom and thecamoebian assemblages suggest oligo- to mesotrophic limnological conditions, and more brackish water than presently occurs in Horseshoe Lake. The onset of the post-settlement period (Zone II) corresponds to distinctive terrestrial and limnological changes. A sharp decline in Quercus at the base of this zone correlates with documented regional riparian deforestation, whereas the increase in the weed taxa Salsola, Brassica, Rumex and Ambrosia is associated with the introduction of European agricultural practices and cereal grasses. Diatom and thecamoebian assemblages indicate progressive floodplain lake eutrophication, as well as increased salinity in Salt Lake. Salt Lake is the most brackish lake and supports the brackish-water foraminifera Trochammina macrescens cf. polystoma. Increased erosion and run off in the watershed has caused a more than twofold increase in lake basin sedimentation between the pre-settlement and post-settlement periods.Cette Ă©tude Ă©tablit une corrĂ©lation entre les changements limnologiques et terrestres dans la plaine d’inondation de trois lacs et le peuplement de la vallĂ©e de la riviĂšre Rouge au Manitoba et dans le Dakota du Nord. Divers assemblages polliniques, de diatomĂ©es et de thĂ©camoĂ©biens mettent en Ă©vidence de façon indirecte des changements Ă©cologiques entre les pĂ©riodes prĂ©- et post-peuplement aux alentours des lacs Horseshoe, Louise et Salt. Dans la pĂ©riode antĂ©rieure au peuplement (Zone I), soit avant 1812, la domination de la signature pollinique des graminĂ©es et du chĂȘne indique un Ă©cosystĂšme forestier riverain composĂ© de graminĂ©es de haute taille et de chĂȘnes. Quant aux assemblages de diatomĂ©es et de thĂ©camoĂ©biens, ils permettent de penser Ă  des conditions limnologiques d’oligo Ă  mĂ©sotrophiques et des eaux plus saumĂątres Ă  cette pĂ©riode qu’actuellement dans le lac Horseshoe. La pĂ©riode post-peuplement (Zone II) correspond Ă  des changements terrestres et limnologiques spĂ©cifiques. Le dĂ©clin marquĂ© du chĂȘne Ă  la base de cette zone correspond en effet Ă  la dĂ©forestation des rives de cette rĂ©gion, telle qu’attestĂ©e dans les documents, tandis que les taxons Salsola, Brassica, Rumex et Ambrosia correspondent Ă  l’instauration de pratiques agricoles europĂ©ennes et la culture des cĂ©rĂ©ales. Les assemblages de diatomĂ©es et de thĂ©camoĂ©biens indiquent aussi une eutrophisation progressive de la plaine inondable de mĂȘme que l’augmentation de la salinitĂ© du lac Salt, ce dernier Ă©tant le plus salĂ© des trois lacs. Il accueille des foraminifĂšres d’eaux saumĂątres du genre Trochammina macrescens cf. polystoma. L’accroissement de l’érosion et du ruissellement dans le bassin-versant a quadruplĂ© la sĂ©dimentation entre les pĂ©riodes prĂ©- et post-peuplement

    A Brownian particle in a microscopic periodic potential

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    We study a model for a massive test particle in a microscopic periodic potential and interacting with a reservoir of light particles. In the regime considered, the fluctuations in the test particle's momentum resulting from collisions typically outweigh the shifts in momentum generated by the periodic force, and so the force is effectively a perturbative contribution. The mathematical starting point is an idealized reduced dynamics for the test particle given by a linear Boltzmann equation. In the limit that the mass ratio of a single reservoir particle to the test particle tends to zero, we show that there is convergence to the Ornstein-Uhlenbeck process under the standard normalizations for the test particle variables. Our analysis is primarily directed towards bounding the perturbative effect of the periodic potential on the particle's momentum.Comment: 60 pages. We reorganized the article and made a few simplifications of the conten

    A vertebrate case study of the quality of assemblies derived from next-generation sequences

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    The unparalleled efficiency of next-generation sequencing (NGS) has prompted widespread adoption, but significant problems remain in the use of NGS data for whole genome assembly. We explore the advantages and disadvantages of chicken genome assemblies generated using a variety of sequencing and assembly methodologies. NGS assemblies are equivalent in some ways to a Sanger-based assembly yet deficient in others. Nonetheless, these assemblies are sufficient for the identification of the majority of genes and can reveal novel sequences when compared to existing assembly references

    Quantifying the Quiet Epidemic: Diagnosing Dementia in Twentieth Century Britain

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    During the late 20(th) century numerical rating scales became central to the diagnosis of dementia and helped transform attitudes about its causes and prevalence. Concentrating largely on the development and use of the Blessed Dementia Scale, I argue that rating scales served professional ends during the 1960s and 1970s. They helped old age psychiatrists establish jurisdiction over conditions such as dementia and present their field as a vital component of the welfare state, where they argued that ‘reliable modes of diagnosis’ were vital to the allocation of resources. I show how these arguments appealed to politicians, funding bodies and patient groups, who agreed that dementia was a distinct disease and claimed research on its causes and prevention should be designated ‘top priority’. But I also show that worries about the replacement of clinical acumen with technical and depersonalized methods, which could conceivably be applied by anyone, led psychiatrists to stress that rating scales had their limits and could be used only by trained experts

    Fact and fiction in housing research: utilizing the creative imagination

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    As much of our conceptual framework is informed by the experience of the imagination, there is much to be learnt from a study of various creative forms. Narrative fiction can be one such form, allowing us to gain a useful insight into complex features of social life. The purpose of this article is to investigate the treatment of housing issues in contemporary literature in order to gain insights into attitudes, experiences and interpretations from the perspective of a broad cultural milieu. Discussions of professionalism, housing tenure and homelessness have tended to be conducted within a narrow framework and adopted orthodox modes of evaluation. Consequently, the neglect of housing within a wider cultural context has reinforced the isolation of housing issues. The article argues that although discussions of housing and housing policy have been seriously limited within the contemporary novel, there are a number of key insights that can be gained from a discussion of issues within a fictional setting

    Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-α by gallbladder epithelial cells: Response to bacterial lipopolysaccharides

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    BACKGROUND: In addition to immune cells, many other cell types are known to produce cytokines. Cultured normal mouse gallbladder epithelial cells, used as a model system for gallbladder epithelium, were examined for their ability to express the mRNA of various cytokines and chemokines in response to bacterial lipopolysaccharide. The synthesis and secretion of the tumor necrosis factor-α (TNF-α) protein by these cells was also measured. RESULTS: Untreated mouse gallbladder cells expressed mRNA for TNF-α, RANTES, and macrophage inflammatory protein-2 (MIP-2). Upon treatment with lipopolysaccharide, these cells now produced mRNA for Interleukin-1ÎČ (IL-1ÎČ), IL-6, monocyte chemoattractant protein-1 (MCP-1), and showed increased expression of TNF-α and MIP-2 mRNA. Untreated mouse gallbladder cells did not synthesize TNF-α protein; however, they did synthesize and secrete TNF-α upon treatment with lipopolysaccharide. METHODS: Cells were treated with lipopolysaccharides from 3 strains of bacteria. Qualitative and semi-quantitative RT-PCR, using cytokine or chemokine-specific primers, was used to measure mRNA levels of TNFα, IL-1ÎČ, IL-6, IL-10, KC, RANTES, MCP-1, and MIP-2. TNF-α protein was measured by immunoassays. CONCLUSION: This research demonstrates that gallbladder epithelial cells in response to lipopolysaccharide exposure can alter their cytokine and chemokine RNA expression pattern and can synthesize and secrete TNFα protein. This suggests a mechanism whereby gallbladder epithelial cells in vivo may mediate gallbladder secretory function, inflammation and diseases in an autocrine/paracrine fashion by producing and secreting cytokines and/or chemokines during sepsis

    Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH

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    Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and selected biochemical variables. Methods: The study was based on women from the Malmo Diet and Cancer Study (MDCS), a prospective, population-based cohort study in Malmo, Sweden. In a previous case-control study on breast cancer, 25OHD3 concentrations had been measured in 727 women. In these, quartiles of serum 25OHD3 were compared with regard to age at baseline, BMI (Body Max Index), menopausal status, use of oral contraceptives or menopausal hormone therapy (MHT), life-style (e. g. smoking and alcohol consumption), socio-demographic factors, season, biochemical variables (i.e. calcium, PTH, albumin, creatinine, and phosphate), and dietary intake of vitamin D and calcium. In order to test differences in mean vitamin D concentrations between different categories of the studied factors, an ANOVA test was used followed by a t-test. The relation between different factors and 25OHD3 was further investigated using multiple linear regression analysis and a logistic regression analysis. Results: We found a positive association between serum levels of 25OHD3 and age, oral contraceptive use, moderate alcohol consumption, blood collection during summer/autumn, creatinine, phosphate, calcium, and a high intake of vitamin D. Low vitamin D levels were associated with obesity, being born outside Sweden and high PTH levels. Conclusions: The present population-based study found a positive association between serum levels of 25OHD3 and to several socio-demographic, life-style and biochemical factors. The study may have implications e. g. for dietary recommendations. However, the analysis is a cross-sectional and it is difficult to suggest Lifestyle changes as cause-effect relationships are difficult to assess
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