The CARMENES search for exoplanets around M dwarfs. Line-by-line sensitivity to activity in M dwarfs

Radial velocities (RVs) measured from high-resolution stellar spectra are routinely used to detect and characterise orbiting exoplanet companions. The different lines present in stellar spectra are created by several species, which are non-uniformly affected by stellar variability features such as spots or faculae. Stellar variability distorts the shape of the spectral absorption lines from which precise RVs are measured, posing one of the main problems in the study of exoplanets. In this work we aim to study how the spectral lines present in M dwarfs are independently impacted by stellar activity. We used CARMENES optical spectra of six active early- and mid-type M dwarfs to compute line-by-line RVs and study their correlation with several well-studied proxies of stellar activity. We are able to classify spectral lines based on their sensitivity to activity in five M dwarfs displaying high levels of stellar activity. We further used this line classification to compute RVs with activity-sensitive lines and less sensitive lines, enhancing or mitigating stellar activity effects in the RV time series. For specific sets of the least activity-sensitive lines, the RV scatter decreases by ~ 2 to 5 times the initial one, depending on the star. Finally, we compare these lines in the different stars analysed, finding the sensitivity to activity to vary from star to star. Despite the high density of lines and blends present in M dwarf stellar spectra, we find that a line-by-line approach is able to deliver precise RVs. Line-by-line RVs are also sensitive to stellar activity effects, and they allow for an accurate selection of activity-insensitive lines to mitigate activity effects in RV. However, we find stellar activity effects to vary in the same insensitive lines from star to star.Comment: Accepted for publication in A&

The CARMENES search for exoplanets around M dwarfs. Behaviour of the Paschen lines during flares and quiescence

The hydrogen Paschen lines are known activity indicators, but studies of them in M~dwarfs during quiescence are as rare as their reports in flare studies. This situation is mostly caused by a lack of observations, owing to their location in the near-infrared regime, which is covered by few high-resolution spectrographs. We study the Pa$\beta$ line, using a sample of 360 M~dwarfs observed by the CARMENES spectrograph. Descending the spectral sequence of inactive M~stars in quiescence, we find the Pa$\beta$ line to get shallower until about spectral type M3.5 V, after which a slight re-deepening is observed. Looking at the whole sample, for stars with H$\alpha$ in absorption, we find a loose anti-correlation between the (median) pseudo-equivalent widths (pEWs) of H$\alpha$ and Pa$\beta$ for stars of similar effective temperature. Looking instead at time series of individual stars, we often find correlation between pEW(H$\alpha$) and pEW(Pa$\beta$) for stars with H$\alpha$ in emission and an anti-correlation for stars with H$\alpha$ in absorption. Regarding flaring activity, we report the automatic detection of 35 Paschen line flares in 20 stars. Additionally we found visually six faint Paschen line flares in these stars plus 16 faint Paschen line flares in another 12 stars. In strong flares, Paschen lines can be observed up to Pa 14. Moreover, we find that Paschen line emission is almost always coupled to symmetric H$\alpha$ line broadening, which we ascribe to Stark broadening, indicating high pressure in the chromosphere. Finally we report a few Pa$\beta$ line asymmetries for flares that also exhibit strong H$\alpha$ line asymmetries.Comment: 21 pages, 22 figures, 7 tables, accepted to A&

The CARMENES search for exoplanets around M dwarfs -- Planet occurrence rates from a subsample of 71 stars

The CARMENES exoplanet survey of M dwarfs has obtained more than 18 000 spectra of 329 nearby M dwarfs over the past five years as part of its guaranteed time observations (GTO) program. We determine planet occurrence rates with the 71 stars from the GTO program for which we have more than 50 observations. We use injection-and-retrieval experiments on the radial-velocity (RV) time series to measure detection probabilities. We include 27 planets in 21 planetary systems in our analysis. We find 0.06+0.04-0.03 giant planets (100 M_Earth < M_pl sin i < 1000 M_Earth) per star in periods of up to 1000 d, but due to a selection bias this number could be up to a factor of five lower in the whole 329-star sample. The upper limit for hot Jupiters (orbital period of less than 10 d) is 0.03 planets per star, while the occurrence rate of planets with intermediate masses (10 M_Earth < M_pl sin i < 100 M_Earth) is 0.18+0.07-0.05 planets per star. Less massive planets with 1 M_Earth < M_pl sin i < 10 M_Earth are very abundant, with an estimated rate of 1.32+0.33-0.31 planets per star for periods of up to 100 d. When considering only late M dwarfs with masses M_star < 0.34 M_sol, planets more massive than 10 M_Earth become rare. Instead, low-mass planets with periods shorter than 10 d are significantly overabundant. For orbital periods shorter than 100 d, our results confirm the known stellar mass dependences from the Kepler survey: M dwarfs host fewer giant planets and at least two times more planets with M_pl sin i < 10 M_Earth than G-type stars. In contrast to previous results, planets around our sample of very low-mass stars have a higher occurrence rate in short-period orbits of less than 10 d. Our results demonstrate the need to take into account host star masses in planet formation models.Comment: 15 pages, 12 figures. Accepted for publication in Astronomy & Astrophysic

The CARMENES search for exoplanets around M dwarfs: Convective shift and starspot constraints from chromatic radial velocities

Context. Variability caused by stellar activity represents a challenge to the discovery and characterization of terrestrial exoplanets and complicates the interpretation of atmospheric planetary signals. Aims. We aim to use a detailed modeling tool to reproduce the effect of active regions on radial velocity measurements, which aids the identification of the key parameters that have an impact on the induced variability. Methods. We analyzed the effect of stellar activity on radial velocities as a function of wavelength by simulating the impact of the properties of spots, shifts induced by convective motions, and rotation. We focused our modeling effort on the active star YZ CMi (GJ 285), which was photometrically and spectroscopically monitored with CARMENES and the Telescopi Joan Or\'o. Results. We demonstrate that radial velocity curves at different wavelengths yield determinations of key properties of active regions, including spot filling factor, temperature contrast, and location, thus solving the degeneracy between them. Most notably, our model is also sensitive to convective motions. Results indicate a reduced convective shift for M dwarfs when compared to solar-type stars (in agreement with theoretical extrapolations) and points to a small global convective redshift instead of blueshift. Conclusions. Using a novel approach based on simultaneous chromatic radial velocities and light curves, we can set strong constraints on stellar activity, including an elusive parameter such as the net convective motion effect.Comment: A&A, in pres

The CARMENES search for exoplanets around M dwarfs -- A deep learning approach to determine fundamental parameters of target stars

Existing and upcoming instrumentation is collecting large amounts of astrophysical data, which require efficient and fast analysis techniques. We present a deep neural network architecture to analyze high-resolution stellar spectra and predict stellar parameters such as effective temperature, surface gravity, metallicity, and rotational velocity. With this study, we firstly demonstrate the capability of deep neural networks to precisely recover stellar parameters from a synthetic training set. Secondly, we analyze the application of this method to observed spectra and the impact of the synthetic gap (i.e., the difference between observed and synthetic spectra) on the estimation of stellar parameters, their errors, and their precision. Our convolutional network is trained on synthetic PHOENIX-ACES spectra in different optical and near-infrared wavelength regions. For each of the four stellar parameters, $T_{\rm eff}$, $\log{g}$, [M/H], and $v \sin{i}$, we constructed a neural network model to estimate each parameter independently. We then applied this method to 50 M dwarfs with high-resolution spectra taken with CARMENES (Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical Echelle Spectrographs), which operates in the visible (520-960 nm) and near-infrared wavelength range (960-1710 nm) simultaneously. Our results are compared with literature values for these stars. They show mostly good agreement within the errors, but also exhibit large deviations in some cases, especially for [M/H], pointing out the importance of a better understanding of the synthetic gap

A comparative evaluation of various invasion assays testing colon carcinoma cell lines

Various colon carcinoma cell lines were tested in different invasion assays, i.e. invasion into Matrigel, into confluent fibroblast layers and into chicken heart tissue. Furthermore, invasive capacity and metastatic potential were determined in nude mice. The colon carcinoma cells used were the human cell lines Caco-2, SW-480, SW-620 and HT-29, and the murine lines Colon-26 and -38. None of the human colon carcinoma cells migrated through porous membranes coated with Matrigel; of the murine lines, only Colon-26 did. When incubated in a mixture of Matrigel and culture medium non-invading cells formed spheroid cultures, whereas invading cells showed a stellate outgrowth. Only the heterogeneously shaped (epithelioid and stellate) cells of SW-480 and SW-620 and the spindle-shaped cells of Colon-26 invaded clearly confluent skin and colon fibroblasts as well as chicken heart tissue. However, when transplanted into the caecum of nude and syngeneic mice, all the lines tested were invasive with the exception of Caco-2 cells. We conclude that the outcome of in vitro tests measuring the invasive capacity of neoplastic cells is largely dependent on the test system used. Invasive capacity in vitro is strongly correlated with cells having a spindle cell shape, vimentin expression and E-cadherin down regulation. In contrast, HT-29 and Colon-38 cells having an epithelioid phenotype were clearly invasive and metastatic in vivo, but not in vitro. © 1999 Cancer Research Campaig

Magnetism, rotation, and nonthermal emission in cool stars: Average magnetic field measurements in 292 M dwarfs

Stellar dynamos generate magnetic fields that are of fundamental importance to the variability and evolution of Sun-like and low-mass stars, and for the development of their planetary systems. As a key to understanding stellar dynamos, empirical relations between stellar parameters and magnetic fields are required for comparison to ab initio predictions from dynamo models. We report measurements of surface-average magnetic fields in 292 M dwarfs from a comparison with radiative transfer calculations; for 260 of them, this is the first measurement of this kind. Our data were obtained from more than 15 000 high-resolution spectra taken during the CARMENES project. They reveal a relation between average field strength, ⟨B⟩, and Rossby number, Ro, resembling the well-studied rotation–activity relation. Among the slowly rotating stars, we find that magnetic flux, ΦB, is proportional to rotation period, P, and among the rapidly rotating stars that average surface fields do not grow significantly beyond the level set by the available kinetic energy. Furthermore, we find close relations between nonthermal coronal X-ray emission, chromospheric Hα and Ca H&K emission, and magnetic flux. Taken together, these relations demonstrate empirically that the rotation–activity relation can be traced back to a dependence of the magnetic dynamo on rotation. We advocate the picture that the magnetic dynamo generates magnetic flux on the stellar surface proportional to rotation rate with a saturation limit set by the available kinetic energy, and we provide relations for average field strengths and nonthermal emission that are independent of the choice of the convective turnover time. We also find that Ca H&K emission saturates at average field strengths of ⟨B⟩≈800 G while Hα and X-ray emission grow further with stronger fields in the more rapidly rotating stars. This is in conflict with the coronal stripping scenario predicting that in the most rapidly rotating stars coronal plasma would be cooled to chromospheric temperatures. © ESO 2022.CARMENES is an instrument at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto (Almería, Spain), operated jointly by the Junta de Andalucía and the Instituto de Astrofísica de Andalucía (CSIC). The authors wish to express their sincere thanks to all members of the Calar Alto staff for their expert support of the instrument and telescope operation. CARMENES was funded by the Max-Planck-Gesellschaft (MPG), the Consejo Superior de Investigaciones Científicas (CSIC), the Ministerio de Economía y Competitividad (MINECO) and the European Regional Development Fund (ERDF) through projects FICTS-2011-02, ICTS-2017-07-CAHA-4, and CAHA16-CE-3978, and the members of the CARMENES Consortium (Max-Planck-Institut für Astronomie, Instituto de Astrofísica de Andalucía, Landessternwarte Königstuhl, Institut de Ciències de l’Espai, Institut für Astrophysik Göttingen, Universidad Complutense de Madrid, Thüringer Landessternwarte Tautenburg, Instituto de Astrofísica de Canarias, Hamburger Sternwarte, Centro de Astrobiología and Centro Astronómico Hispano-Alemán), with additional contributions by the MINECO, the Deutsche Forschungsgemeinschaft through the Major Research Instrumentation Programme and Research Unit FOR2544 “Blue Planets around Red Stars”, the Klaus Tschira Stiftung, the states of Baden-Württemberg and Niedersachsen, by the Junta de Andalucía. We acknowledge financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia e Innovación and the ERDF “A way of making Europe” through project PID2019-109522GB-C5[1:4]/AEI/10.13039/501100011033 and the Centre of Excellence “Severo Ochoa” and “María de Maeztu” awards to the Instituto de Astrofísica de Canarias (CEX2019-000920-S), Instituto de Astrofísica de Andalucía (SEV-2017-0709), and Centro de Astrobiología (MDM-2017-0737), the Deutsche Forschungsgemeinschaft Heisenberg programme (KA4825/4-1), and the Generalitat de Catalunya/CERCA programme.Peer reviewe

Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

The c-MET receptor can be overexpressed, amplified, or mutated in solid tumours including small cell lung cancer (SCLC). In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal transduction was detected, namely adducin-α [S724], adducin-γ [S662], CREB [S133], ERK1 [T185/Y187], ERK1/2 [T202/Y204], ERK2 [T185/Y187], MAPKK (MEK) 1/2 [S221/S225], MAPKK (MEK) 3/6 [S189/S207], RB [S612], RB1 [S780], JNK [T183/Y185], STAT3 [S727], focal adhesion kinase (FAK) [Y576/S722/S910], p38α-MAPK [T180/Y182], and AKT1[S473] and [T308]. Conversely, inhibition of phosphorylation by HGF in protein kinase C (PKC), protein kinase R (PKR), and also CDK1 was identified. Phosphoantibody-based immunohistochemical analysis of SCLC tumour tissue and microarray established the role of c-MET in SCLC biology. This supports a role of c-MET activation in tumour invasive front in the tumour progression and invasion involving FAK and AKT downstream. The c-MET serves as an attractive therapeutic target in SCLC, as shown through small interfering RNA (siRNA) and selective prototype c-MET inhibitor SU11274, inhibiting the phosphorylation of c-MET itself and its downstream molecules such as AKT, S6 kinase, and ERK1/2. Investigation of mechanisms of invasion and, ultimately, metastasis in SCLC would be very useful with these signal transduction molecules

The CARMENES search for exoplanets around M dwarfs, Wolf 1069 b: Earth-mass planet in the habitable zone of a nearby, very low-mass star

We present the discovery of an Earth-mass planet ($M_b\sin i = 1.26\pm0.21M_\oplus$) on a 15.6d orbit of a relatively nearby ($d\sim$9.6pc) and low-mass ($0.167\pm0.011 M_\odot$) M5.0V star, Wolf 1069. Sitting at a separation of $0.0672\pm0.0014$au away from the host star puts Wolf 1069b in the habitable zone (HZ), receiving an incident flux of $S=0.652\pm0.029S_\oplus$. The planetary signal was detected using telluric-corrected radial-velocity (RV) data from the CARMENES spectrograph, amounting to a total of 262 spectroscopic observations covering almost four years. There are additional long-period signals in the RVs, one of which we attribute to the stellar rotation period. This is possible thanks to our photometric analysis including new, well-sampled monitoring campaigns undergone with the OSN and TJO facilities that supplement archival photometry (i.e., from MEarth and SuperWASP), and this yielded an updated rotational period range of $P_{rot}=150-170$d, with a likely value at $169.3^{+3.7}_{-3.6}$d. The stellar activity indicators provided by the CARMENES spectra likewise demonstrate evidence for the slow rotation period, though not as accurately due to possible factors such as signal aliasing or spot evolution. Our detectability limits indicate that additional planets more massive than one Earth mass with orbital periods of less than 10 days can be ruled out, suggesting that perhaps Wolf 1069 b had a violent formation history. This planet is also the 6th closest Earth-mass planet situated in the conservative HZ, after Proxima Centauri b, GJ 1061d, Teegarden's Star c, and GJ 1002 b and c. Despite not transiting, Wolf 1069b is nonetheless a very promising target for future three-dimensional climate models to investigate various habitability cases as well as for sub-ms$^{-1}$ RV campaigns to search for potential inner sub-Earth-mass planets in order to test planet formation theories.Comment: 26 pages, 15 figure

An ultra-short-period transiting super-Earth orbiting the M3 dwarf TOI-1685

Funding: We acknowledge financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades and the ERDF through projects PID2019-109522GB-C5[1:4]/AEI/10.13039/501100011033, PGC2018-098153-B-C33, and the Centre of Excellence “Severo Ochoa” and “María deMaeztu” awards to the Instituto de Astrofísica de Canarias (SEV-2015-0548), Instituto de Astrofísica de Andalucía (SEV-2017-0709), and Centro de Astro-biología (MDM-2017-0737), the Generalitat de Catalunya/CERCA programme,“la Caixa” Foundation (100010434), European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 847648 (LCF/BQ/PI20/11760023), a University Research Support Grant from the National Astronomical Observatory of Japan, JSPS KAKENHI (JP15H02063, JP18H01265, JP18H05439, JP18H05442, and JP22000005), JSTPRESTO (JPMJPR1775), UK Science and Technology Facilities Council (ST/R000824/1), and NASA (NNX17AG24G).Dynamical histories of planetary systems, as well as the atmospheric evolution of highly irradiated planets, can be studied by characterizing the ultra-short-period planet population, which the TESS mission is particularly well suited to discover. Here, we report on the follow-up of a transit signal detected in the TESS sector 19 photometric time series of the M3.0 V star TOI-1685 (2MASS J04342248+4302148). We confirm the planetary nature of the transit signal, which has a period of Pb = 0.6691403−0.0000021+0.0000023 d, using precise radial velocity measurements taken with the CARMENES spectrograph. From the joint photometry and radial velocity analysis, we estimate the following parameters for TOI-1685 b: a mass of Mb = 3.78−0.63+0.63 M⊕, a radius of Rb = 1.70−0.07+0.07 R⊕, which together result in a bulk density of ρb = 4.21−0.82+0.95 g cm−3, and an equilibrium temperature of Teq = 1069−16+16 K. TOI-1685 b is the least dense ultra-short-period planet around an M dwarf known to date. TOI-1685 b is also one of the hottest transiting super-Earth planets with accurate dynamical mass measurements, which makes it a particularly attractive target for thermal emission spectroscopy. Additionally, we report with moderate evidence an additional non-transiting planet candidate in the system, TOI-1685 [c], which has an orbital period of Pc = 9.02−0.12+0.10 d.Publisher PDFPeer reviewe