31 research outputs found

    Avaliação da amplitude articular do joelho: correlação entre as medidas realizadas com o goniômetro universal e no dinamômetro isocinético

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    CONTEXTUALIZAÇÃO: O instrumento mais utilizado pelos terapeutas para mensuração da amplitude de movimento (ADM) articular é o goniômetro universal. No entanto, há carência de estudos que analisem a confiabilidade das medidas da ADM do joelho realizadas no dinamômetro isocinético. OBJETIVO: O objetivo deste estudo foi analisar a correlação entre as medidas de ADM na articulação do joelho, realizadas com o goniômetro universal e no dinamômetro isocinético. MÉTODO: Foram avaliados 38 voluntários saudáveis (27 mulheres, 11 homens), com idade de 36 ± 11 anos, com limitação mínima de 20° na ADM de extensão do joelho. No membro dominante de cada sujeito foram realizadas três mensurações da ADM do joelho com o goniômetro e três mensurações no dinamômetro. RESULTADOS: Os resultados deste estudo mostraram que há alto grau de correlação entre as medidas da ADM do joelho obtidas com o goniômetro universal e no dinamômetro isocinético (Coeficiente de Correlação de Pearson = 0,90). CONCLUSÃO: Com os procedimentos realizados, tanto o goniômetro universal como o dinamômetro isocinético podem ser utilizados para avaliação da ADM do joelho, pois ambos apresentam mensurações confiáveis.<br>BACKGROUND: The instrument most often used by therapists for measuring joint range of motion (ROM) is the universal goniometer. However, there is a lack of studies analyzing the reliability of knee joint ROM measured by the isokinetic dynamometer. OBJECTIVE: The purpose of this study was to analyze the correlation between the knee joint ROM measurements made using a universal goniometer and an isokinetic dynamometer. METHOD: 38 healthy volunteers (27 women, 11 men) aged 36 ± 11 years were evaluated. All of them had a minimum knee extension ROM limitation of 20°. Three knee ROM measurements were made using the universal goniometer and another three using the isokinetic dynamometer, on each subject's dominant limb. RESULTS: The results showed a high degree of correlation between the knee ROM measurements made using the two instruments (Pearson correlation coefficient = 0.90). CONCLUSION: From the procedures performed, both the universal goniometer and the isokinetic dynamometer can be used to evaluate knee ROM, since they both present reliable measurements

    Poor Regenerative Outcome after Skeletal Muscle Necrosis Induced by Bothrops asper Venom: Alterations in Microvasculature and Nerves

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    artículo (arbitrado) -- Universidad de Costa Rica, Instituto de Investigaciones Clodomiro Picado. 2011Background: Viperid snakebite envenoming is characterized by prominent local tissue damage, including muscle necrosis. A frequent outcome of such local pathology is deficient skeletal muscle regeneration, which causes muscle dysfunction, muscle loss and fibrosis, thus provoking permanent sequelae that greatly affect the quality of life of patients. The causes of such poor regenerative outcome of skeletal muscle after viperid snakebites are not fully understood. Methodology/Principal Findings: A murine model of muscle necrosis and regeneration was adapted to study the effects of the venom and isolated toxins of Bothrops asper, the medically most important snake in Central America. Gastrocnemius muscle was injected with either B. asper venom, a myotoxic phospholipase A2 (Mtx), a hemorrhagic metalloproteinase (SVMP), or saline solution. At various time intervals, during one month, tissue samples were collected and analyzed by histology, and by immunocytochemical and immunohistochemical techniques aimed at detecting muscle fibers, collagen, endothelial cells, myoblasts, myotubes, macrophages, TUNEL-positive nuclei, and axons. A successful regenerative response was observed in muscle injected with Mtx, which induces myonecrosis but does not affect the microvasculature. In contrast, poor regeneration, with fibrosis and atrophic fibers, occurred when muscle was injected with venom or SVMP, both of which provoke necrosis, microvascular damage leading to hemorrhage, and poor axonal regeneration. Conclusions/Significance: The deficient skeletal muscle regeneration after injection of B. asper venom is likely to depend on the widespread damage to the microvasculature, which affects the removal of necrotic debris by phagocytes, and the provision of nutrients and oxygen required for regeneration. In addition, deficient axonal regeneration is likely to contribute to the poor regenerative outcome in this model.This study was supported by NeTropica (grant 2-N-2008), by Vicerrectoría de Investigación, Universidad de Costa Rica (project 741-A7-604). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP

    Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins

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    Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking severe local pathology which often results in permanent sequelae. In contrast, the venom of the South American rattlesnake Crotalus durissus terrificus, induces a clinical picture of systemic myotoxicity, i.e., rhabdomyolysis, together with neurotoxicity. It is known that molecules released from damaged muscle might act as ‘danger’ signals. These are known as ‘alarmins’, and contribute to the inflammatory reaction by activating the innate immune system. Here we show that the venoms of B. asper and C. d. terrificus release the mitochondrial markers mtDNA (from the matrix) and cytochrome c (Cyt c) from the intermembrane space, from ex vivo mouse tibialis anterior muscles. Cyt c was released to a similar extent by the two venoms whereas B. asper venom induced the release of higher amounts of mtDNA, thus reflecting hitherto some differences in their pathological action on muscle mitochondria. At variance, injection of these venoms in mice resulted in a different time-course of mtDNA release, with B. asper venom inducing an early onset increment in plasma levels and C. d. terrificus venom provoking a delayed release. We suggest that the release of mitochondrial ‘alarmins’ might contribute to the local and systemic inflammatory events characteristic of snakebite envenomations

    Reeducação postural global e alongamento estático segmentar na melhora da flexibilidade, força muscular e amplitude de movimento: um estudo comparativo

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    Exercícios de alongamento são usados para aumentar a flexibilidade e amplitude de movimento (ADM). Entre os métodos existentes, destacam-se a reeducação postural global (RPG), que promove o alongamento global das cadeias musculares, e o alongamento segmentar, que alonga um músculo ou grupo muscular específico. Este estudo visou comparar o alongamento segmentar e o global pela técnica de RPG quanto ao ganho de flexibilidade, ADM e força muscular. Trinta mulheres foram distribuídas aleatoriamente em três grupos (n=10 em cada): o grupo global fez alongamento de cadeias musculares; o grupo segmentar realizou alongamento segmentar; e o grupo controle não fez alongamento. Antes e depois do tratamento, em todos os grupos, foram avaliadas a ADM de extensão da perna, flexibilidade pelo teste 3o dedo-solo e força isométrica de flexão da perna em 45° e 90°. Os dois grupos experimentais realizaram oito sessões de alongamento de 30 minutos cada, duas vezes por semana. Toda a análise estatística foi realizada com pStretching exercises are prescribed to increase flexibility and range of motion (ROM). Two current stretching methods are the global posture reeducation (GPR), where muscle chains are stretched, and segmentary exercises, where a single muscle or muscle group is stretched. The aim of this study was to compare these two techniques, assessing their effects on improving flexibility, ROM and muscle strength. Thirty women were randomly distributed into three groups (n=10 each): global group performed stretching following GPR method; segment group performed segment stretching exercises; and control group did no exercise. Before and after treatment, in all groups, knee extension ROM, flexibility by means of the fingertip-to-floor test, and isometric muscular strength at 45° and 90° knee flexion were measured. Each treated group performed eight stretching 30-minute sessions for four weeks, twice a week. Data were statistically analysed and the significance level set at p<0.05. Global and segment group results were similar and better than control group's concerning ROM, flexibility and muscle strength at 45° and 90° knee flexion (p<0.05). When assessing improvement inter-sessions, both groups had better ROM improvement at the first sessions, decreasing along the others. Both global and segmentary stretching techniques were hence found effective in improving flexibility, ROM and leg muscle strength
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