Collapsed bipolar glycolipids at the air/water interface: Effect of the stereochemistry on the stretched/bent conformations.

International audienceThis article describes a comparative study of several bipolar lipids derived from tetraether structures. The sole structural difference between the main two glycolipids is a unique stereochemical variation on a cyclopentyl ring placed in the middle of the lipids. We discuss the comparative results obtained at the air/water interface on the basis of tensiometry and ellipsometry. Langmuir-Blodgett depositions during lipid film compressions and decompressions were also analyzed by AFM. The lactosylated tetraether (bipolar) lipid structures involved the formation of highly stable multilayers, which are still present at 10mNm(-1) during decompression. This study suggests also that the stereochemistry of a central cyclopentyl ring dramatically drives the conformation of the corresponding bipolar lipids. Both isomers (trans and cis) adopt a U-shaped (bent) conformation at the air/water interface but the trans cyclopentyl ring induces a much more frustration within this type of conformation. Consequently, this bipolar lipid (trans-tetraether) undergoes a flip of one polar head-group (lactosyl) leading to a stretched conformation during collapse

TDAE Strategy in the Benzoxazolone Series: Synthesis and Reactivity of a New Benzoxazolinonic Anion

International audienceWe describe an original pathway to produce new 5-substituted 3-methyl-6-nitro-benzoxazolones by the reaction of aromatic carbonyl and α-carbonyl ester derivatives with a benzoxazolinonic anion formed exclusively via the TDAE strategy

Dépression iatrogène médicamenteuse

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

La maladie d'Alzheimer (description et rôles du pharmacien d'officine dans sa prise en charge)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Hemodyalise (Principes et critères de choix des membranes)

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF

Comprendre la maladie d'Alzheimer, la prévenir et accompagner les malades

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A la recherche de nouveaux candidats médicaments

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L'asthme et ses traitements

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Ostéoporose post-ménopausique et traitement par le dénosumab

AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF