Three-dimensional contrast transfer functions in propagation-based tomography

A single-step method is developed for three-dimensional reconstruction of the spatial distribution of complex refractive index in weakly scattering objects from multiple planar transmission images. The images are collected using coherent or partially-coherent illumination at a range of incident directions in the Fresnel region after free-space propagation from the object to the detector. The method is based on the contrast transfer function formalism extended to the cases of partially-coherent illumination and strongly absorbing samples. The proposed tomographic methods can be used for 3D reconstruction of internal structure of objects with X-rays, electrons and other forms of radiation and matter waves. Compared to related previously published methods for propagation-based phase-contrast tomography, the results reported in the present paper can be applied to a wider range of imaging conditions and can be also advantageous in terms of computational efficiency and robustness with respect to noise

A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron

Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X-ray energy, source size, detector resolution, sample-to-detector distance, scanning and data processing strategies in the case of propagation-based phase-contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast-tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 μm, revealed the presence of propagation-based phase contrast and demonstrated significant improvement of the quality of phase-contrast CT imaging compared with conventional (absorption-based) CT, at medically acceptable radiation doses

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the standard 2D mammography technique, including spatial and contrast resolution. In this study, we propose an approach to improve the detection of microcalcifications in propagation-based phase-contrast X-ray computed tomography of breast tissues. Five fresh mastectomies containing microcalcifications were scanned at different X-ray energies and radiation doses using synchrotron radiation. Both bright-field (i.e. conventional phase-retrieved images) and dark-field images were extracted from the same data sets using different image processing methods. A quantitative analysis was performed in terms of visibility and contrast-to-noise ratio of microcalcifications. The results show that while the signal-to-noise and the contrast-to-noise ratios are lower, the visibility of the microcalcifications is more than two times higher in the dark-field images compared to the bright-field images. Dark-field images have also provided more accurate information about the size and shape of the microcalcifications

Elemental Contrast X-ray Tomography Using Ross Filter Pairs with a Polychromatic Laboratory Source

The majority of current laboratory based X-ray sources are polychromatic and are not tuneable. This lack of monochromaticity limits the range of applications for these sources and in particular it reduces the elemental specificity of laboratory based X-ray imaging experiments. Here we present a solution to this problem based on the use of Ross filter pairs. Although such Ross filter arrangements have been applied in proof-of-principle spectroscopy experiments, to date there have been no reports of this approach used for full-field X-ray imaging. Here we report on the experimental demonstration of Ross filter pairs being used for quasi-monochromatic, full-field imaging. This arrangement has several important benefits for laboratory based X-ray imaging including, as we demonstrate, elemental contrast enhancement. The method is demonstrated both for two-dimensional radiography and for three-dimensional X-ray tomography

Evaluation of Spatial Resolution and Noise Sensitivity of sLORETA Method for EEG Source Localization Using Low-Density Headsets

Electroencephalography (EEG) has enjoyed considerable attention over the pastcentury and has been applied for diagnosis of epilepsy, stroke, traumatic braininjury and other disorders where 3D localization of electrical activity in thebrain is potentially of great diagnostic value. In this study we evaluate theprecision and accuracy of spatial localization of electrical activity in thebrain delivered by a popular reconstruction technique sLORETA applied to EEGdata collected by two commonly used low-density headsets with 14 and 19measurement channels, respectively. Numerical experiments were performed for arealistic head model obtained by segmentation of MRI images. The EEG sourcelocalization study was conducted with a simulated single active dipole, as wellas with two spatially separated simultaneously active dipoles, as a function ofdipole positions across the neocortex, with several different noise levels inthe EEG signals registered on the scalp. The results indicate that while thereconstruction accuracy and precision of the sLORETA method are consistentlyhigh in the case of a single active dipole, even with the low-resolution EEGconfigurations considered in the present study, successful localization is muchmore problematic in the case of two simultaneously active dipoles. Thequantitative analysis of the width of the reconstructed distributions of theelectrical activity allows us to specify the lower bound for the spatialresolution of the sLORETA-based 3D source localization in the considered cases