541 research outputs found
Torque-onset determination: Unintended consequences of the threshold method.
BACKGROUND: Compared with visual torque-onset-detection (TOD), threshold-based TOD produces onset bias, which increases with lower torques or rates of torque development (RTD). PURPOSE: To compare the effects of differential TOD-bias on common contractile parameters in two torque-disparate groups. METHODS: Fifteen boys and 12 men performed maximal, explosive, isometric knee-extensions. Torque and EMG were recorded for each contraction. Best contractions were selected by peak torque (MVC) and peak RTD. Visual-TOD-based torque-time traces, electromechanical delays (EMD), and times to peak RTD (tRTD) were compared with corresponding data derived from fixed 4-Nm- and relative 5%MVC-thresholds. RESULTS: The 5%MVC TOD-biases were similar for boys and men, but the corresponding 4-Nm-based biases were markedly different (40.3±14.1 vs. 18.4±7.1ms, respectively; p<0.001). Boys-men EMD differences were most affected, increasing from 5.0ms (visual) to 26.9ms (4Nm; p<0.01). Men's visually-based torque kinetics tended to be faster than the boys' (NS), but the 4-Nm-based kinetics erroneously depicted the boys as being much faster to any given %MVC (p<0.001). CONCLUSIONS: When comparing contractile properties of dissimilar groups, e.g., children vs. adults, threshold-based TOD methods can misrepresent reality and lead to erroneous conclusions. Relative-thresholds (e.g., 5% MVC) still introduce error, but group-comparisons are not confounded
In vivo gene transfer to the brain cortex using a single injection of HSV-1 vector into the medial septum
This study shows that an ICP4-replication-deficient herpes simplex virus containing
the Moloney murine leukaemia virus LTR fused with the coding sequence
for the beta-galactosidase gene can be used as a very effective vector for
delivering the beta-galactosidase reporter gene into the rat brain septum. F344
rats received bilateral stereotaxic injections into the nucleus of the diagonal
band and into the medial septum. The X-gal stain was used to detect the
activity of the expressed beta-galactosidase enzyme. The delivered reporter gene
was expressed successfully not only in the neuronal cells of the injected areas
but also in cells that project to the injection area such as cortex cells about
6 mm away from the injection sites. Expression was visible at 1, 3 and 9 weeks
following injection. We conclude that this vector can effectively deliver genes
into different regions of the mature mammalian brain and also to areas distant
from the injection site
Quantifying the impact of climate change on drought regimes using the Standardised Precipitation Index
The study presents a methodology to characterise short- or long-term drought events, designed to aid understanding of how climate change may affect future risk. An indicator of drought magnitude, combining parameters of duration, spatial extent and intensity, is presented based on the Standardised Precipitation Index (SPI). The SPI is applied to observed (1955–2003) and projected (2003–2050) precipitation data from the Community Integrated Assessment System (CIAS). Potential consequences of climate change on drought regimes in Australia, Brazil, China, Ethiopia, India, Spain, Portugal and the USA are quantified. Uncertainty is assessed by emulating a range of global circulation models to project climate change. Further uncertainty is addressed through the use of a high-emission scenario and a low stabilisation scenario representing a stringent mitigation policy. Climate change was shown to have a larger effect on the duration and magnitude of long-term droughts, and Australia, Brazil, Spain, Portugal and the USA were highlighted as being particularly vulnerable to multi-year drought events, with the potential for drought magnitude to exceed historical experience. The study highlights the characteristics of drought which may be more sensitive under climate change. For example, on average, short-term droughts in the USA do not become more intense but are projected to increase in duration. Importantly, the stringent mitigation scenario had limited effect on drought regimes in the first half of the twenty-first century, showing that adaptation to drought risk will be vital in these regions
Transit Photometry as an Exoplanet Discovery Method
Photometry with the transit method has arguably been the most successful
exoplanet discovery method to date. A short overview about the rise of that
method to its present status is given. The method's strength is the rich set of
parameters that can be obtained from transiting planets, in particular in
combination with radial velocity observations; the basic principles of these
parameters are given. The method has however also drawbacks, which are the low
probability that transits appear in randomly oriented planet systems, and the
presence of astrophysical phenomena that may mimic transits and give rise to
false detection positives. In the second part we outline the main factors that
determine the design of transit surveys, such as the size of the survey sample,
the temporal coverage, the detection precision, the sample brightness and the
methods to extract transit events from observed light curves. Lastly, an
overview over past, current and future transit surveys is given. For these
surveys we indicate their basic instrument configuration and their planet
catch, including the ranges of planet sizes and stellar magnitudes that were
encountered. Current and future transit detection experiments concentrate
primarily on bright or special targets, and we expect that the transit method
remains a principal driver of exoplanet science, through new discoveries to be
made and through the development of new generations of instruments.Comment: Review chapte
Orbifold equivalence for finite density QCD and effective field theory
In the large N_c limit, some apparently different gauge theories turn out to
be equivalent due to large N_c orbifold equivalence. We use effective field
theory techniques to explore orbifold equivalence, focusing on the specific
case of a recently discovered relation between an SO(2N_c) gauge theory and
QCD. The equivalence to QCD has been argued to hold at finite baryon chemical
potential, \mu_B, so long as one deforms the SO(2N_c) theory by certain
"double-trace" terms. The deformed SO(2N_c) theory can be studied without a
sign problem in the chiral limit, in contrast to SU(N_c) QCD at finite \mu_B.
The purpose of the double-trace deformation in the SO(2N_c) theory is to
prevent baryon number symmetry from breaking spontaneously at finite density,
which is necessary for the equivalence to large N_c QCD to be valid. The
effective field theory analysis presented here clarifies the physical
significance of double-trace deformations, and strongly supports the proposed
equivalence between the deformed SO(2N_c) theory and large N_c QCD at finite
density.Comment: 39 pages, 5 figures, 2 tables. v2: Minor typo fixes and
clarification
Two Earth-sized planets orbiting Kepler-20
Since the discovery of the first extrasolar giant planets around Sun-like
stars, evolving observational capabilities have brought us closer to the
detection of true Earth analogues. The size of an exoplanet can be determined
when it periodically passes in front of (transits) its parent star, causing a
decrease in starlight proportional to its radius. The smallest exoplanet
hitherto discovered has a radius 1.42 times that of the Earth's radius (R
Earth), and hence has 2.9 times its volume. Here we report the discovery of two
planets, one Earth-sized (1.03R Earth) and the other smaller than the Earth
(0.87R Earth), orbiting the star Kepler-20, which is already known to host
three other, larger, transiting planets. The gravitational pull of the new
planets on the parent star is too small to measure with current
instrumentation. We apply a statistical method to show that the likelihood of
the planetary interpretation of the transit signals is more than three orders
of magnitude larger than that of the alternative hypothesis that the signals
result from an eclipsing binary star. Theoretical considerations imply that
these planets are rocky, with a composition of iron and silicate. The outer
planet could have developed a thick water vapour atmosphere.Comment: Letter to Nature; Received 8 November; accepted 13 December 2011;
Published online 20 December 201
A tunable carbon nanotube electromechanical oscillator
Nanoelectromechanical systems (NEMs) hold promise for a number of scientific
and technological applications. In particular, NEMs oscillators have been
proposed for use in ultrasensitive mass detection, radio-frequency signal
processing, and as a model system for exploring quantum phenomena in
macroscopic systems. Perhaps the ultimate material for these applications is a
carbon nanotube. They are the stiffest material known, have low density,
ultrasmall cross-sections and can be defect-free. Equally important, a nanotube
can act as a transistor and thus may be able to sense its own motion. In spite
of this great promise, a room-temperature, self-detecting nanotube oscillator
has not been realized, although some progress has been made. Here we report the
electrical actuation and detection of the guitar-string-like oscillation modes
of doubly clamped nanotube oscillators. We show that the resonance frequency
can be widely tuned and that the devices can be used to transduce very small
forces.Comment: 9 pages, 3 figure
Meta-analysis for dorsally displaced distal radius fracture fixation: volar locking plate versus percutaneous Kirschner wires
Clinical management of gastric cancer: results of a multicentre survey
<p>Abstract</p> <p>Background</p> <p>The National Comprehensive Cancer Network clinical practice guidelines in oncology-gastric cancer guidelines have been widely used to provide appropriate recommendations for the treatment of patients with gastric cancer. The aim of this study was to examine the adherence of surgical oncologists, medical oncologists, and radiation oncologists' to the recommended guidelines.</p> <p>Methods</p> <p>A questionnaire asking the treatment options for gastric cancer cases was sent to 394 Chinese oncology specialists, including surgical oncologists, medical oncologists, and radiation oncologists working in hospitals joined in The Western Cooperative Gastrointestinal Oncology Group of China. The questionnaire involved a series of clinical scenarios regarding the interpretation of surgery, neoadjuvant, adjuvant, and advanced treatment planning of gastric cancer.</p> <p>Results</p> <p>Analysis of 358 respondents (91%) showed variations between each specialization and from the recommended guidelines in the management approaches to specific clinical scenarios. The majority of specialists admitted that less than 50% of patients received multidisciplinary evaluation before treatment. The participants gave different responses to questions involving adjuvant, neoadjuvant, and advanced settings, compared to the recommended guidelines.</p> <p>Conclusions</p> <p>These results highlight the heterogeneity of the treatment of gastric cancer. Surgical oncologists, medical oncologists, and radiation oncologists are not adhering to the recommended guidelines.</p
Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis
<p>Abstract</p> <p>Background</p> <p>Viral bronchiolitis is the leading cause of hospitalization in young infants. It is associated with the development of childhood asthma and contributes to morbidity and mortality in the elderly. Currently no therapies effectively attenuate inflammation during the acute viral infection, or prevent the risk of post-viral asthma. We hypothesized that early treatment of a paramyxoviral bronchiolitis with azithromycin would attenuate acute and chronic airway inflammation.</p> <p>Methods</p> <p>Mice were inoculated with parainfluenza type 1, Sendai Virus (SeV), and treated daily with PBS or azithromycin for 7 days post-inoculation. On day 8 and 21 we assessed airway inflammation in lung tissue, and quantified immune cells and inflammatory mediators in bronchoalveolar lavage (BAL).</p> <p>Results</p> <p>Compared to treatment with PBS, azithromycin significantly attenuated post-viral weight loss. During the peak of acute inflammation (day 8), azithromycin decreased total leukocyte accumulation in the lung tissue and BAL, with the largest fold-reduction in BAL neutrophils. This decreased inflammation was independent of changes in viral load. Azithromycin significantly attenuated the concentration of BAL inflammatory mediators and enhanced resolution of chronic airway inflammation evident by decreased BAL inflammatory mediators on day 21.</p> <p>Conclusions</p> <p>In this mouse model of paramyxoviral bronchiolitis, azithromycin attenuated acute and chronic airway inflammation. These findings demonstrate anti-inflammatory effects of azithromycin that are not related to anti-viral activity. Our findings support the rationale for future prospective randomized clinical trials that will evaluate the effects of macrolides on acute viral bronchiolitis and their long-term consequences.</p
- …