Non-resonant nonlinear coupling of magnetohydrodynamic waves in inhomogeneous media

RevTex4, 4 pages, 4 figuresRevTex4, 4 pages, 4 figuresRevTex4, 4 pages, 4 figuresA new mechanism for the enhanced generation of compressible fluctuations by Alfven waves is presented. A strongly nonlinear regime of Alfven wave phase-mixing is numerically simulated in a one-dimensionally inhomogeneous plasma of finite temperature. It is found that the inhomogeneity of the medium determines the efficiency of nonlinear excitation of magnetoacoustic waves. The level of the compressible fluctuations is found to be higher (up to the factor of two) in inhomogeneous regions. The amplitude of the generated magnetoacoustic wave can reach up to 30% of the source Alfven wave amplitude, and this value is practically independent of the Alfven wave amplitude and the steepness of Alfven speed profile. The highest amplitudes of compressible disturbances are reached in plasmas with beta of about 0.5. The further growth of the amplitude of compressible fluctuations is depressed by saturation

The Nature and Excitation Mechanisms of Acoustic Oscillations in Solar and Stellar Coronal Loops

talk at SOHO15, St. Andrews, Scotland, 6-9 September, 2004, to appear in SOHO15 proceedingstalk at SOHO15, St. Andrews, Scotland, 6-9 September, 2004, to appear in SOHO15 proceedingstalk at SOHO15, St. Andrews, Scotland, 6-9 September, 2004, to appear in SOHO15 proceedingstalk at SOHO15, St. Andrews, Scotland, 6-9 September, 2004, to appear in SOHO15 proceedingsIn the recent work of Nakariakov et al. (2004), it has been shown that the time dependences of density and velocity in a flaring loop contain pronounced quasi-harmonic oscillations associated with the 2nd harmonic of a standing slow magnetoacoustic wave. That model used a symmetric heating function (heat deposition was strictly at the apex). This left outstanding questions: A) is the generation of the 2nd harmonic a consequence of the fact that the heating function was symmetric? B) Would the generation of these oscillations occur if we break symmetry? C) What is the spectrum of these oscillations? Is it consistent with a 2nd spatial harmonic? The present work (and partly Tsiklauri et al. (2004b)) attempts to answer these important outstanding questions. Namely, we investigate the physical nature of these oscillations in greater detail: we study their spectrum (using periodogram technique) and how heat positioning affects the mode excitation. We found that excitation of such oscillations is practically independent of location of the heat deposition in the loop. Because of the change of the background temperature and density, the phase shift between the density and velocity perturbations is not exactly a quarter of the period, it varies along the loop and is time dependent, especially in the case of one footpoint (asymmetric) heating. We also were able to model successfully SUMER oscillations observed in hot coronal loops

Homing and Long-Term Engraftment of Long- and Short-Term Renewal Hematopoietic Stem Cells

Long-term hematopoietic stem cells (LT-HSC) and short-term hematopoietic stem cells (ST-HSC) have been characterized as having markedly different in vivo repopulation, but similar in vitro growth in liquid culture. These differences could be due to differences in marrow homing. We evaluated this by comparing results when purified ST-HSC and LT-HSC were administered to irradiated mice by three different routes: intravenous, intraperitoneal, and directly into the femur. Purified stem cells derived from B6.SJL mice were competed with marrow cells from C57BL/6J mice into lethally irradiated C57BL/6J mice. Serial transplants into secondary recipients were also carried out. We found no advantage for ST-HSC engraftment when the cells were administered intraperitoneally or directly into femur. However, to our surprise, we found that the purified ST-HSC were not short-term in nature but rather gave long-term multilineage engraftment out to 387 days, albeit at a lower level than the LT-HSC. The ST-HSC also gave secondary engraftment. These observations challenge current models of the stem cell hierarchy and suggest that stem cells are in a continuum of change

Loss of ATF2 Function Leads to Cranial Motoneuron Degeneration during Embryonic Mouse Development

The AP-1 family transcription factor ATF2 is essential for development and tissue maintenance in mammals. In particular, ATF2 is highly expressed and activated in the brain and previous studies using mouse knockouts have confirmed its requirement in the cerebellum as well as in vestibular sense organs. Here we present the analysis of the requirement for ATF2 in CNS development in mouse embryos, specifically in the brainstem. We discovered that neuron-specific inactivation of ATF2 leads to significant loss of motoneurons of the hypoglossal, abducens and facial nuclei. While the generation of ATF2 mutant motoneurons appears normal during early development, they undergo caspase-dependent and independent cell death during later embryonic and foetal stages. The loss of these motoneurons correlates with increased levels of stress activated MAP kinases, JNK and p38, as well as aberrant accumulation of phosphorylated neurofilament proteins, NF-H and NF-M, known substrates for these kinases. This, together with other neuropathological phenotypes, including aberrant vacuolisation and lipid accumulation, indicates that deficiency in ATF2 leads to neurodegeneration of subsets of somatic and visceral motoneurons of the brainstem. It also confirms that ATF2 has a critical role in limiting the activities of stress kinases JNK and p38 which are potent inducers of cell death in the CNS

A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity

Non-steroidal anti-inflammatory drugs (NSAIDs) represent a diverse class of drugs and are among the most commonly used analgesics for arthritic pain worldwide, though long-term use is associated with a spectrum of adverse effects. The introduction of cyclooxygenase-2-selective NSAIDs early in the last decade offered an alternative to traditional NSAIDs with similar efficacy and improved gastrointestinal tolerability; however, emerging concerns about cardiovascular safety resulted in the withdrawal of two agents (rofecoxib and valdecoxib) in the mid-2000s and, subsequently, in an overall reduction in NSAID use. It is now understood that all NSAIDs are associated with some varying degree of gastrointestinal and cardiovascular risk. Guidelines still recommend their use, but little is known of how patients use these agents. While strategies and guidelines aimed at reducing NSAID-associated complications exist, there is a need for evidence-based algorithms combining cardiovascular and gastrointestinal factors that can be used to aid treatment decisions at an individual patient level

Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick

Background The cranial sensory ganglia represent populations of neurons with distinct functions, or sensory modalities. The production of individual ganglia from distinct neurogenic placodes with different developmental pathways provides a powerful model to investigate the acquisition of specific sensory modalities. To date there is a limited range of gene markers available to examine the molecular pathways underlying this process. Results Transcriptional profiles were generated for populations of differentiated neurons purified from distinct cranial sensory ganglia using microdissection in embryonic chicken followed by FAC-sorting and RNAseq. Whole transcriptome analysis confirmed the division into somato- versus viscerosensory neurons, with additional evidence for subdivision of the somatic class into general and special somatosensory neurons. Cross-comparison of distinct ganglia transcriptomes identified a total of 134 markers, 113 of which are novel, which can be used to distinguish trigeminal, vestibulo-acoustic and epibranchial neuronal populations. In situ hybridisation analysis provided validation for 20/26 tested markers, and showed related expression in the target region of the hindbrain in many cases. Results One hundred thirty-four high-confidence markers have been identified for placode-derived cranial sensory ganglia which can now be used to address the acquisition of specific cranial sensory modalities.</p