910 research outputs found
Geometric phases and Andreev reflection in hybrid rings
We study the Andreev reflection of a hybrid mesoscopic ring in the presence
of a crown-like magnetic texture. By calculating the linear-response
conductance as a function of the Zeeman splitting and the magnetic flux through
the ring, we are able to identify signatures of the Berry phase acquired by the
electrons during transport. This is proposed as a novel detection scheme of the
spin-related Berry phase, having the advantage of a larger signal contrast and
robustness against ensemble averaging.Comment: 6 pages, 6 figures. To appear in Phys. Rev.
Nonlinear shot noise in mesoscopic diffusive normal-superconducting systems
We study differential shot noise in mesoscopic diffusive
normal-superconducting (NS) heterostructures at finite voltages where nonlinear
effects due to the superconducting proximity effect arise. A numerical
scattering-matrix approach is adopted. Through an NS contact, we observe that
the shot noise shows a reentrant dependence on voltage due to the
superconducting proximity effect but the differential Fano factor stays
approximately constant. Furthermore, we consider differential shot noise in the
structures where an insulating barrier is formed between normal and
superconducting regions and calculate the differential Fano factor as a
function of barrier height.Comment: 4 pages, 6 figure
Zig-Zag magnetic order and potential Kitaev interactions in the spin-1 honeycomb lattice KNiAsO
Despite the exciting implications of the Kitaev spin-Hamiltonian, finding and
confirming the quantum spin liquid state has proven incredibly difficult.
Recently the applicability of the model has been expanded through the
development of a microscopic description of a spin-1 Kitaev interaction. Here
we explore a candidate spin-1 honeycomb system, KNiAsO , which meets many
of the proposed criteria to generate such an interaction. Bulk measurements
reveal an antiferromagnetic transition at 19 K which is generally robust
to applied magnetic fields. Neutron diffraction measurements show magnetic
order with a ordering vector which results in
the well-known ``zig-zag" magnetic structure thought to be adjacent to the
spin-liquid ground state. Field dependent diffraction shows that while the
structure is robust, the field can tune the direction of the ordered moment.
Inelastic neutron scattering experiments show a well defined gapped spin-wave
spectrum with no evidence of the continuum expected for fractionalized
excitations. Modeling of the spin waves shows that the extended Kitaev
spin-Hamiltonians is generally necessary to model the spectra and reproduce the
observed magnetic order. First principles calculations suggest that the
substitution of Pd on the Ni sublattice may strengthen the Kitaev interactions
while simultaneously weakening the exchange interactions thus pushing
KNiAsO closer to the spin-liquid ground state.Comment: 13 pages, 7 figure
Spin current shot noise as a probe of interactions in mesoscopic systems
It is shown that the spin resolved current shot noise can probe attractive or
repulsive interactions in mesoscopic systems. This is illustrated in two
physical situations : i) a normal-superconducting junction where the spin
current noise is found to be zero, and ii) a single electron transistor (SET),
where the spin current noise is found to be Poissonian. Repulsive interactions
may also lead to weak attractive correlations (bunching of opposite spins) in
conditions far from equilibrium. Spin current shot noise can be used to measure
the spin relaxation time , and a set-up is proposed in a quantum dot
geometry.Comment: 5 pages, 4 Figures, revised version, added reference
Energy dependent counting statistics in diffusive superconducting tunnel junctions
We present an investigation of the energy dependence of the full charge
counting statistics in diffusive
normal-insulating-normal-insulating-superconducting junctions. It is found that
the current in general is transported via a correlated transfer of pairs of
electrons. Only in the case of strongly asymmetric tunnel barriers or energies
much larger than the Thouless energy is the pair transfer uncorrelated. The
second cumulant, the noise, is found to depend strongly on the applied voltage
and temperature. For a junction resistance dominated by the tunnel barrier to
the normal reservoir, the differential shot noise shows a double peak feature
at voltages of the order of the Thouless energy, a signature of an ensemble
averaged electron-hole resonance.Comment: 8 pages, 5 figure
Mutator Dynamics on a Smooth Evolutionary Landscape
We investigate a model of evolutionary dynamics on a smooth landscape which
features a ``mutator'' allele whose effect is to increase the mutation rate. We
show that the expected proportion of mutators far from equilibrium, when the
fitness is steadily increasing in time, is governed solely by the transition
rates into and out of the mutator state. This results is a much faster rate of
fitness increase than would be the case without the mutator allele. Near the
fitness equilibrium, however, the mutators are severely suppressed, due to the
detrimental effects of a large mutation rate near the fitness maximum. We
discuss the results of a recent experiment on natural selection of E. coli in
the light of our model.Comment: 4 pages, 3 figure
Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies
Background: The 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies and action plans based on available data and information from countries of sub-Saharan Africa and beyond. We estimated trends from 1980 to 2014 in age-standardized mean body mass index (BMI) and diabetes prevalence in these countries, in order to assess the co-progression and assist policy formulation.
Methods: We pooled data from African and worldwide population-based studies which measured height, weight and biomarkers to assess diabetes status in adults aged ≥ 18 years. A Bayesian hierarchical model was used to estimate trends by sex for 200 countries and territories including 53 countries across five African regions (central, eastern, northern, southern and western), in mean BMI and diabetes prevalence (defined as either fasting plasma glucose of ≥ 7.0 mmol/l, history of diabetes diagnosis, or use of insulin or oral glucose control agents).
Results: African data came from 245 population-based surveys (1.2 million participants) for BMI and 76 surveys (182 000 participants) for diabetes prevalence estimates. Countries with the highest number of data sources for BMI were South Africa (n = 17), Nigeria (n = 15) and Egypt (n = 13); and for diabetes estimates, Tanzania (n = 8), Tunisia (n = 7), and Cameroon, Egypt and South Africa (all n = 6). The age-standardized mean BMI increased from 21.0 kg/m2 (95% credible interval: 20.3–21.7) to 23.0 kg/m2 (22.7–23.3) in men, and from 21.9 kg/m2 (21.3–22.5) to 24.9 kg/m2 (24.6–25.1) in women. The age-standardized prevalence of diabetes increased from 3.4% (1.5–6.3) to 8.5% (6.5–10.8) in men, and from 4.1% (2.0–7.5) to 8.9% (6.9–11.2) in women. Estimates in northern and southern regions were mostly higher than the global average; those in central, eastern and western regions were lower than global averages. A positive association (correlation coefficient ≃ 0.9) was observed between mean BMI and diabetes prevalence in both sexes in 1980 and 2014.
Conclusions: These estimates, based on limited data sources, confirm the rapidly increasing burden of diabetes in Africa. This rise is being driven, at least in part, by increasing adiposity, with regional variations in observed trends. African countries’ efforts to prevent and control diabetes and obesity should integrate the setting up of reliable monitoring systems, consistent with the World Health Organization’s Global Monitoring System Framework
Farnesylated Nuclear Proteins Kugelkern and Lamin Dm0 Affect Nuclear Morphology by Directly Interacting with the Nuclear Membrane
Nuclear shape changes are observed during a variety of developmental processes, pathological conditions and ageing. Here, the molecular mechanism is analyzed how the farnesylated nuclear proteins interact with the nuclear envelope and deform the phospholipid bilayer
Telomere Length and Mental Well-Being in Elderly Men from the Netherlands and Greece
Telomeres, repetitive DNA sequences that promote chromosomal stability, have been related to different measures of mental well-being and self-rated health, but mainly in women during adulthood. We aimed to investigate whether accelerated telomere shortening is associated with poor mental well-being and poor self-rated health in community-dwelling elderly men. Leukocyte telomere length was measured using quantitative PCR in two different samples of 203 elderly men (mean age 78 years) from the Netherlands in 1993, and 123 elderly men (mean age 84 years) from Greece in 2000. We also obtained follow-up data in 2000 from 144 Dutch subjects, of whom 75 had paired telomere length data in 1993 and 2000. Mental well-being was conceptualized as dispositional optimism, depressive symptoms, cognitive functioning, and loneliness. Linear regression analyses were used to study the association between telomere length, measures of mental well being, and self-rated health, while adjusting for potential confounders. In cross-sectional analyses, leukocyte telomere length was not associated with measures of mental well-being and self-rated health, neither in the Netherlands nor in Greece. Also, the rate of leukocyte telomere shortening (mean decrease: 0.28 kbp over 7 years) in the 75 Dutch participants with longitudinal data was not associated with changes in different measures of mental well-being and self-rated health. Thus, our results provide no support for a relationship between leukocyte telomere length and mental well-being in elderly community-dwelling men
A GPU implementation of a track-repeating algorithm for proton radiotherapy dose calculations
An essential component in proton radiotherapy is the algorithm to calculate
the radiation dose to be delivered to the patient. The most common dose
algorithms are fast but they are approximate analytical approaches. However
their level of accuracy is not always satisfactory, especially for
heterogeneous anatomic areas, like the thorax. Monte Carlo techniques provide
superior accuracy, however, they often require large computation resources,
which render them impractical for routine clinical use. Track-repeating
algorithms, for example the Fast Dose Calculator, have shown promise for
achieving the accuracy of Monte Carlo simulations for proton radiotherapy dose
calculations in a fraction of the computation time. We report on the
implementation of the Fast Dose Calculator for proton radiotherapy on a card
equipped with graphics processor units (GPU) rather than a central processing
unit architecture. This implementation reproduces the full Monte Carlo and
CPU-based track-repeating dose calculations within 2%, while achieving a
statistical uncertainty of 2% in less than one minute utilizing one single GPU
card, which should allow real-time accurate dose calculations
- …