256 research outputs found
Search for neutral heavy leptons produced in decays
Weak isosinglet Neutral Heavy Leptons (Îœm) have been searched for using data collected by the DELPHI detector corresponding to 3.3 Ă 106 hadronic Z0 decays at LEP1. Four separate searches have been performed, for short-lived Îœm production giving monojet or acollinear jet topologies, and for long-lived Îœm giving detectable secondary vertices or calorimeter clusters. No indication of the existence of these particles has been found, leading to an upper limit for the branching ratio BR(Z0 â ÎœmÎœÌ) of about 1.3 Ă 10-6 at 95% confidence level for Îœm masses between 3.5 and 50 GeV/c2. Outside this range the limit weakens rapidly with the Îœm mass. The results are also interpreted in terms of limits for the single production of excited neutrinos. © Springer-Verlag 1997
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
Letter to the Editor: Assignment of the H-1, C-13, and N-15 resonances of the AXH domain of the transcription factor HBP1
no abstrac
Letter to the Editor: Assignment of the H-1, C-13, and N-15 resonances of the AXH domain of the transcription factor HBP1
no abstrac
Letter to the Editor: NMR assignment of the H-1, N-15 and C-13 resonances of the E-coli frataxin orthologue, CyaY
no abstrac
Letter to the Editor: NMR assignment of the H-1, N-15 and C-13 resonances of the E-coli frataxin orthologue, CyaY
no abstrac
C-13 AND PROTON TWO-DIMENSIONAL NMR-STUDY OF THE ORMOSIA ALKALOIDS PANAMINE, ORMOSANINE, AND ORMOSININE
Letter to the Editor: Assignment of the H-1, C-13 and N-15 resonances of the C-terminal EF-hands of alpha-actinin in a 14 kDa complex with Z-repeat 7 of titin
Letter to the Editor: Assignment of the H-1, C-13, and N-15 resonances of the Josephin domain of human ataxin-3
The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine proteases, sharing the highest degree of structural similarity with bacterial staphopain. A currently unique structural feature of Josephin is a flexible helical hairpin formed by a 32-residue insertion, which could determine substrate specificity. By using the Josephin structure and the availability of NMR chemical shift assignments, we have mapped the enzyme active site by using the typical cysteine protease inhibitors, transepoxysuccinyl-L-eucylamido-4-guanidino-butane (E-64) and [L-3-trans-(propylcarbamyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline (CA-074). We also demonstrate that the specific interaction of Josephin with the ubiquitin-like domain of the ubiquitin- and proteasome-binding factor HHR23B involves complementary exposed hydrophobic surfaces. The structural similarity with other deubiquitinating enzymes suggests a model for the proteolytic enzymatic activity of ataxin-3
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