4,432 research outputs found
Self Piercing Riveting for Metal-Polymer Joints
Self-Piercing Riveting (SPR) is a sheet metal joining technique based on the insertion of a rivet into two or more sheets, with no preparatory hole. This process has gained wide diffusion in the automotive industry, due to the increasing use of materials alternative to steel, that are difficult or impossible to join with traditional techniques. In particular, polymeric materials are becoming increasingly used, due to their favorable weight/strength ratio. This paper reports the results of experimental investigations, aimed at identifying the variables affecting the mechanical characteristics of mixed metal-plastic joints. A statistic model for the optimization of the geometrical parameters has been computed. The paper demonstrates that self-piercing riveting appears competitive for metal/polymer junction. The results analyzed in light of statistical techniques show that some geometrical parameters affect joint performance more than others and can therefore be used as independent variables for joint performance optimizatio
Identification of neutral tumor evolution across cancer types
A.S. is supported by The Chris Rokos Fellowship in Evolution and Cancer.
B.W. is supported by the Geoffrey W. Lewis Post-Doctoral Training fellowship.
This work was supported by the Wellcome Trust (105104/Z/14/Z). C.P.B.
acknowledges funding from the Wellcome Trust through a Research Career
Development Fellowship (097319/Z/11/Z). This work was supported by a
Cancer Research UK Career Development Award to T.A.G. M.J.W. is supported
by a UK Medical Research Council student fellowship
Glueball Interpretation of (2230)
On the basis of the results of
and , measured by the BES Collaboration in radiative J/ decays,
combined with the upper limit of Br()Br(), measured by PS185 experiment, we argue
that the distinctive properties of (2230), the flavor-symmetric decays and
the narrow partial decay widths to and as well as its
copious production in radiative J/ decay, would strongly favor the
glueball interpretation of (2230).Comment: Latex file, no figure
A note on possible interpretations for the observed by SELEX
We suggest some possible interpretations for the observed by
SELEX. The could be the first radial excitation of the
ground state (2112), and its unusual decay patten might be
hopefully explained by the node structure of the wave functions. In addition,
the could also be a hybrid state or a
(diquark-antidiquark) bound state.Comment: final version to appear in Phys. Lett. B, references adde
Enzymatic degradation ofRNAcauses widespread protein aggregation in cell and tissue lysates
Most proteins in cell and tissue lysates are soluble. We show here that in lysate from human neurons, more than 1,300 proteins are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably leads to protein aggregation. The majority of these proteins lack conventional RNA‐binding domains. Using synthetic oligonucleotides, we identify the importance of nucleic acid structure, with single‐stranded pyrimidine‐rich bulges or loops surrounded by double‐stranded regions being particularly efficient in the maintenance of protein solubility. These experiments also identify an apparent one‐to‐one protein‐nucleic acid stoichiometry. Furthermore, we show that protein aggregates isolated from brain tissue from Amyotrophic Lateral Sclerosis patients can be rendered soluble after refolding by both RNA and synthetic oligonucleotides. Together, these findings open new avenues for understanding the mechanism behind protein aggregation and shed light on how certain proteins remain soluble
A Sparse Stress Model
Force-directed layout methods constitute the most common approach to draw
general graphs. Among them, stress minimization produces layouts of
comparatively high quality but also imposes comparatively high computational
demands. We propose a speed-up method based on the aggregation of terms in the
objective function. It is akin to aggregate repulsion from far-away nodes
during spring embedding but transfers the idea from the layout space into a
preprocessing phase. An initial experimental study informs a method to select
representatives, and subsequent more extensive experiments indicate that our
method yields better approximations of minimum-stress layouts in less time than
related methods.Comment: Appears in the Proceedings of the 24th International Symposium on
Graph Drawing and Network Visualization (GD 2016
Preliminary Limits on the WIMP-Nucleon Cross Section from the Cryogenic Dark Matter Search (CDMS)
We are conducting an experiment to search for WIMPs, or weakly-interacting
massive particles, in the galactic halo using terrestrial detectors. This
generic class of hypothetical particles, whose properties are similar to those
predicted by extensions of the standard model of particle physics, could
comprise the cold component of non-baryonic dark matter. We describe our
experiment, which is based on cooled germanium and silicon detectors in a
shielded low-background cryostat. The detectors achieve a high degree of
background rejection through the simultaneous measurement of the energy in
phonons and ionization. Using exposures on the order of one kilogram-day from
initial runs of our experiment, we have achieved (preliminary) upper limits on
the WIMP-nucleon cross section that are comparable to much longer runs of other
experiments.Comment: 5 LaTex pages, 5 eps figs, epsf.sty, espcrc2dsa2.sty. Proceedings of
TAUP97, Gran Sasso, Italy, 7-11 Sep 1997, Nucl. Phys. Suppl., A. Bottino, A.
di Credico and P. Monacelli (eds.). See also http://cfpa.berkeley.ed
A robust SNP barcode for typing Mycobacterium tuberculosis complex strains
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance. Several systems have been proposed to classify MTBC strains into distinct lineages and families. Here, we investigate single-nucleotide polymorphisms (SNPs) as robust (stable) markers of genetic variation for phylogenetic analysis. We identify ~92k SNP across a global collection of 1,601 genomes. The SNP-based phylogeny is consistent with the gold-standard regions of difference (RD) classification system. Of the ~7k strain-specific SNPs identified, 62 markers are proposed to discriminate known circulating strains. This SNP-based barcode is the first to cover all main lineages, and classifies a greater number of sublineages than current alternatives. It may be used to classify clinical isolates to evaluate tools to control the disease, including therapeutics and vaccines whose effectiveness may vary by strain type
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