DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPLC METHOD FOR THE ESTIMATION OF RABEPRAZOLE IMPURITIES IN PHARMACEUTICAL DOSAGE FORMS BY DESIGN OF EXPERIMENTS

A novel stability-indicating reverse phase liquid chromatographic method was developed for the determination of Rabeprazole impurities in Rabeprazole tablet formulations. One unknown impurity was isolated and characterized by using MS and NMR, which was formed in the formulated drug stability study. Rabeprazole was subjected to the stress conditions like oxidative, acid, base, hydrolytic, thermal and photolytic degradation. Chromatographic separation was achieved on HPLC in gradient elution mode by QbD-approach. The eluted compounds were monitored at 280 nm. All the impurities and degradation products were well resolved from the main peak, proving the stability-indicating power of the method. On the basis of spectral data, the unknown impurity was characterized as 1-(1H -Benzimidazol-2-yl)-4-(3-methoxypropoxy)-3-methylpyridinium-2-carboxylate. The developed method was validated as per International Conference on Harmonization (ICH) guidelines with respect to specificity, limit of detection, limit of quantification, precision, linearity, accuracy, robustness and ruggedness Keywords: Rabeprazole, QbD approach, Degradation Products, Stability-Indicating, ICH Guideline

Herbal Remedies for Hair Disorders by the Tribals of East Godavari District, Andhra Pradesh

The present study deals with the documentation of ethnomedicinal plants used for curing hair disorders by the tribals of East Godavari district, Andhra Pradesh. The study resulted in the documentation of 35 medicinal plant species belonging to 34 genera and 24 families used for hair wash, alopecia, dandruff, cooling effect, hair tonic, lice killing and hair tonic. Fabaceae is the dominant family followed by Malvaceae, Combretaceae, Rubiaceae and Sapindaceae

Secured and Smart Electronic voting system

Now a days various displays are  becoming available for implementing a new kind of human computer interaction (HCI) method. Among them, touch  panel  displays  have  been used in wide variety of applications and are proven to be a useful interface infrastructure. We exemplify our approach through the design and development of secured & smart ectronic voting system. As the Supreme Court recently ordered to include the “Reject” option, so that the voter can reject if he is not interested in any party. This touch screen  based electronic voting system provides confirmation after selecting a party from the list. A beep sound will be generated when the voter presses the confirmation so that the vote will be casted successfully to a right party. This type of electronic voting systems allow easy confirmation and casting of vote without any assistance. This system also provides security by entering the voter ID whether it is correct or not. We also conducted a preliminary evaluation to verify the effectiveness of the system

A Remotely Operable Facility for Fabrication of Fuel Pins for test Irradiation

AbstractA laboratory scale facility has been set up for fabrication of test fuel pins through sol-gel route for irradiation in FBTR, Kalpakkam. The facility is a train of glove boxes fitted with master slave manipulators for carrying out various operations involved in the fuel fabricat ion process. The paper describes the design features of the equipment and mechanisms for automation, developed for microsphere production and other processes. The design features include control system and vision systems for man- machine interface

Spin Susceptibility and Superexchange Interaction in the Antiferromagnet CuO

Evidence for the quasi one-dimensional (1D) antiferromagnetism of CuO is presented in a framework of Heisenberg model. We have obtained an experimental absolute value of the paramagnetic spin susceptibility of CuO by subtracting the orbital susceptibility separately from the total susceptibility through the $^{63}$Cu NMR shift measurement, and compared directly with the theoretical predictions. The result is best described by a 1D $S=1/2$ antiferromagnetic Heisenberg (AFH) model, supporting the speculation invoked by earlier authors. We also present a semi-quantitative reason why CuO, seemingly of 3D structure, is unexpectedly a quasi 1D antiferromagnet.Comment: 7 pages including 4 tables and 9 figure

Disordered Type-II Superconductors: A Universal Phase Diagram for Low-Tc_c Systems

A universal phase diagram for weakly pinned low-T$_c$ type-II superconductors is revisited and extended with new proposals. The low-temperature ``Bragg glass'' phase is argued to transform first into a disordered, glassy phase upon heating. This glassy phase, a continuation of the high-field equilibrium vortex glass phase, then melts at higher temperatures into a liquid. This proposal provides an explanation for the anomalies observed in the peak effect regime of 2H-NbSe$_2$ and several other low-T$_c$ materials which is independent of the microscopic mechanisms of superconductivity in these systems.Comment: 23 pages, 9 figure

Strong and weak chaos in weakly nonintegrable many-body Hamiltonian systems

We study properties of chaos in generic one-dimensional nonlinear Hamiltonian lattices comprised of weakly coupled nonlinear oscillators, by numerical simulations of continuous-time systems and symplectic maps. For small coupling, the measure of chaos is found to be proportional to the coupling strength and lattice length, with the typical maximal Lyapunov exponent being proportional to the square root of coupling. This strong chaos appears as a result of triplet resonances between nearby modes. In addition to strong chaos we observe a weakly chaotic component having much smaller Lyapunov exponent, the measure of which drops approximately as a square of the coupling strength down to smallest couplings we were able to reach. We argue that this weak chaos is linked to the regime of fast Arnold diffusion discussed by Chirikov and Vecheslavov. In disordered lattices of large size we find a subdiffusive spreading of initially localized wave packets over larger and larger number of modes. The relations between the exponent of this spreading and the exponent in the dependence of the fast Arnold diffusion on coupling strength are analyzed. We also trace parallels between the slow spreading of chaos and deterministic rheology.Comment: 15 pages, 14 figure

A study of supercooling of the disordered vortex phase via minor hysteresis loops in 2H-NbSe_2

We report on the observation of novel features in the minor hysteresis loops in a clean crystal of NbSe_2 which displays a peak effect. The observed behavior can be explained in terms of a supercooling of the disordered vortex phase while cooling the superconductor in a field. Also, the extent of spatial order in a flux line lattice formed in ascending fields is different from (and larger than) that in the descending fields below the peak position of the peak effect; this is attributed to unequal degree of annealing of the state induced by a change of field in the two cases.Comment: 5 pages of text + 6 figures, submitted to Phys. Rev.

Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3) : a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Altres ajuts: Canadian Institutes of Health Research (CIHR, FDN-143302); General Research Fund (14104419), Research Grant Council, Hong Kong SAR, China; National Health and Medical Research Council, Funding Schemes (NHMRC Project Grant 1162362), Australia; McMaster University Department of Medicine Career Research Award and a Physicians' Services Incorporated (PSI) Foundation Mid-Career Clinical Research Award.Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e., most patients continue their antihypertensive medications throughout the perioperative period and intraoperative mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve perioperative outcomes. Methods: The PeriOperative Ischemic Evaluation (POISE)-3 Trial is a large international randomized controlled trial designed to determine if TXA is superior to placebo for the composite outcome of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic events, at 30 days after randomization. Using a partial factorial design, POISE-3 will additionally determine the effect of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of major cardiovascular events, at 30 days after randomization. The target sample size is 10,000 participants. Patients ≥45 years of age undergoing noncardiac surgery, with or at risk of cardiovascular and bleeding complications, are randomized to receive a TXA 1 g intravenous bolus or matching placebo at the start and at the end of surgery. Patients, health care providers, data collectors, outcome adjudicators, and investigators are blinded to the treatment allocation. Patients on ≥ 1 chronic antihypertensive medication are also randomized to either of the two blood pressure management strategies, which differ in the management of patient antihypertensive medications on the morning of surgery and on the first 2 days after surgery, and in the target mean arterial pressure during surgery. Outcome adjudicators are blinded to the blood pressure treatment allocation. Patients are followed up at 30 days and 1 year after randomization. Discussion: Bleeding and hypotension in noncardiac surgery are common and have a substantial impact on patient prognosis. The POISE-3 trial will evaluate two interventions to determine their impact on bleeding, cardiovascular complications, and mortality. Trial registration: ClinicalTrials.gov NCT03505723. Registered on 23 April 2018