The Strong Isospin-Breaking Correction for the Gluonic Penguin Contribution to epsilon'/epsilon at Next-to-Leading Order in the Chiral Expansion

The strong isospin-breaking correction, Omega_{st}, which appears in estimates of the Standard Model value for the direct CP-violating ratio epsilon'/epsilon, is evaluated to next-to-leading order (NLO) in the chiral expansion using Chiral Perturbation Theory. The relevant linear combinations of the unknown NLO CP-odd weak low-energy constants (LEC's) which, in combination with 1-loop and strong LEC contributions, are required for a complete determination at this order, are estimated using two different models. It is found that, to NLO, Omega_{st}=0.08 +/- 0.05, significantly reduced from the ``standard'' value, 0.25 +/- 0.08, employed in recent analyses. The potentially significant numerical impact of this decrease on Standard Model predictions for epsilon'/epsilon, associated with the decreased cancellation between gluonic penguin and electroweak penguin contributions, is also discussed.Comment: 12 pages, 1 figur

Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning

Efficient laccase/TEMPO oxidation of alkyl glycosides : Effects of carbohydrate group and alkyl chain length

Alkyl glycosides with long hydrophobic chains have attractive surfactant properties, but their wider application is hampered by their low solubility in water. Here, a route to increased solubility by introduction of carboxyl groups via laccase/TEMPO oxidation is presented. The oxidation pathways for dodecyl β-maltoside and hexadecyl β-maltoside were studied in detail. Close to full conversion was achieved for both substrates and conditions were found under which the diacid products dominated, with only minor amounts of under-oxidized and over-oxidized products. Dodecyl β-maltoside oxidation was improved to give a yield of 85 % of the diacid derivative. Interestingly, in spite of low substrate solubility the oxidation of hexadecyl β-maltoside was very efficient in aqueous medium, due to the higher solubility of the products. Addition of organic cosolvents did not provide additional advantages. The method is promising for producing soluble anionic derivatives of alkyl glycosides in an environmentally friendly and efficient way