How culture influences perspective taking: differences in correction, not integration

Individuals from East Asian (Chinese) backgrounds have been shown to exhibit greater sensitivity to a speaker’s perspective than Western (U.S.) participants when resolving referentially ambiguous expressions. We show that this cultural difference does not reflect better integration of social information during language processing, but rather is the result of differential correction: in the earliest moments of referential processing, Chinese participants showed equivalent egocentric interference to Westerners, but managed to suppress the interference earlier and more effectively. A time-series analysis of visual-world eye-tracking data found that the two cultural groups diverged extremely late in processing, between 600 and 1400 ms after the onset of egocentric interference. We suggest that the early moments of referential processing reflect the operation of a universal stratum of processing that provides rapid ambiguity resolution at the cost of accuracy and flexibility. Late components, in contrast, reflect the mapping of outputs from referential processes to decision-making and action planning systems, allowing for a flexibility in responding that is molded by culturally specific demands

Heavy-to-light transition form factors and their relations in light-cone QCD sum rules

The improved light-cone QCD sum rules by using chiral current correlator is systematically reviewed and applied to the calculation of all the heavy-to-light form factors, including all the semileptonic and penguin ones. By choosing suitable chiral currents, the light-cone sum rules for all the form factors are greatly simplified and depend mainly on one leading twist distribution amplitude of the light meson. As a result, relations between these form factors arise naturally. At the considered accuracy these relations reproduce the results obtained in the literature. Moreover, since the explicit dependence on the leading twist distribution amplitudes is preserved, these relations may be more useful to simulate the experimental data and extract the information on the distribution amplitude.Comment: 1+16 pages, no figure

mGovernment Services and Adoption: Current Research and Future Direction

Part 5: Research in ProgressInternational audienceWith the unprecedented growth of mobile technologies, governments of both developed and developing countries have started adopting mobile services in the form of m-government. While the vendors and practitioners are heavily engaged in this transformation, the scholarly world is lagging to keep pace with the progress and to provide clear theoretical guidance for successful adoption. This paper takes a stock of scholarly publications on m-government adoption since the year 2000 and reports findings and future directions based on meta-analysis of secondary data. The articles were classified into research themes, delivery mode, theory and methods. The paper identifies the dearth of scholarly work and calls for more in-depth work to make important contribution in this area

Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: a review of preclinical and clinical studies

The mesenchymal-epithelial transition (MET) receptor tyrosine kinase binds the hepatocyte growth factor to activate downstream cell signaling pathways involved in cell proliferation, survival, and migration. Several genetic mechanisms can result in an aberrant activation of this receptor in cancer cells. One such activating mechanism involves the acquisition of gene mutations that cause MET exon 14 skipping (METex14) during mRNA splicing. Mutations leading to METex14 are found in approximately 3?4% of patients with non-small cell lung cancer (NSCLC). Accumulating evidence suggests that METex14 is a true, independent oncogenic driver in NSCLC, as well as being an independent prognostic factor for poorer survival in patients with NSCLC. The successes of target therapies have relied on improved understanding of the genetic alterations that lead to the dysregulation of the molecular pathways and more advanced molecular diagnostics. Multiple efforts have been made to target the MET pathway in cancer; however, real clinical progress has only occurred since the emergence of METex14 as a valid biomarker for MET inhibition. Capmatinib is a highly potent and selective type Ib inhibitor of MET. Following preclinical demonstration of activity against MET-dependent cancer cell line growth and METdriven tumor growth in xenograft models, data from a phase 1 clinical trial showed an acceptable safety profile of capmatinib and preliminary evidence of efficacy in patients with MET-dysregulated NSCLC. The multicohort GEOMETRY mono-1 phase 2 trial reported objective response rates of 68% and 41% in treatment-na?ve and in pre-treated patients with METex14 advanced NSCLC, respectively. These results have supported the approval of capmatinib by the US Food and Drug Administration for patients with metastatic NSCLC harboring METex14.Pathogenesis and treatment of chronic pulmonary disease

Study of Bs-> \phi l^+ l^-$ Decay in a Single Universal Extra Dimension

Utilizing form factors calculated within the light-cone sum rules, we have evaluated the decay branching ratios of $B_s\to \phi\gamma$ and $B_s\to \phi \ell^+\ell^-$ in a single universal extra dimension model (UED), which is viewed as one of the alternative theories beyond the standard model (SM). For the decay $B_s \to \phi \ell^+\ell^-$, the dilepton invariant mass spectra, the forward-backward asymmetry, and double lepton polarization are also calculated. For each case, we compared the obtained results with predictions of the SM. In lower values of the compactification factor 1/R, the only parameter in this model, we see the considerable discrepancy between the UED and SM models. However, when 1/R increases, the results of UED tend to diminish and at $1/R = 1000 \mathrm{GeV}$, two models have approximately the same predictions. Compared with data from CDF of $B_s \to \phi \mu^+ \mu^-$, the 1/R tends to be larger than $350 \mathrm{GeV}$. We also note that the zero crossing point of the forward-backward asymmetry is become smaller, which will be an important plat to prob the contribution from the extra dimension model. The results obtained in this work will be very useful in searching new physics beyond SM. Moreover, the order of magnitude for branching ratios shows a possibility to study these channels at the Large Hadron Collider (LHC), CDF and the future super-B factory.Comment: 13 pages, 16 figure

Amplitude to phase conversion of InGaAs pin photo-diodes for femtosecond lasers microwave signal generation

When a photo-diode is illuminated by a pulse train from a femtosecond laser, it generates microwaves components at the harmonics of the repetition rate within its bandwidth. The phase of these components (relative to the optical pulse train) is known to be dependent on the optical energy per pulse. We present an experimental study of this dependence in InGaAs pin photo-diodes illuminated with ultra-short pulses generated by an Erbium-doped fiber based femtosecond laser. The energy to phase dependence is measured over a large range of impinging pulse energies near and above saturation for two typical detectors, commonly used in optical frequency metrology with femtosecond laser based optical frequency combs. When scanning the optical pulse energy, the coefficient which relates phase variations to energy variations is found to alternate between positive and negative values, with many (for high harmonics of the repetition rate) vanishing points. By operating the system near one of these vanishing points, the typical amplitude noise level of commercial-core fiber-based femtosecond lasers is sufficiently low to generate state-of-the-art ultra-low phase noise microwave signals, virtually immune to amplitude to phase conversion related noise.Comment: 7 pages, 6 figures, submitted to Applied Physics

Analysis of B_s->\phi \ell^+ \ell^- decay with new physics effects

The rare B_s-> \phi \ell^+ \ell^- decay is investigated by using the most general model independent effective Hamiltonian for $\ell= \mu, \tau$. The calculated Br(B_s \rar \phi \mu^+ \mu^-) = 1.92 \times 10^{-6} is in consistent with the experimental upper bound. The dependencies of the branching ratios and polarization asymmetries of leptons and combined lepton-antilepton asymmetries on the new Wilson coefficients are presented. The analysis shows that the branching ratios and the lepton polarization asymmetries are very sensitive to the scalar and tensor type interactions. The results obtained in this work will be very useful in searching new physics beyond the standard model.Comment: 28 pages, 14 figure

Extreme ultraviolet-excited time-resolved luminescence spectroscopy using an ultrafast table-top high-harmonic generation source

We present a table-top extreme ultraviolet (XUV) beamline for measuring time- and frequency-resolved XUV excited optical luminescence (XEOL) with additional femtosecond-resolution XUV transient absorption spectroscopy functionality. XUV pulses are generated via high-harmonic generation using a near-infrared pulse in a noble gas medium, and focused to excite luminescence from a solid sample. The luminescence is collimated and guided into a streak camera, where its spectral components are temporally resolved with picosecond temporal resolution. We time-resolve XUV excited luminescence and compare the results to luminescence decays excited at longer wavelengths for three different materials : (i) sodium salicylate, an often used XUV scintillator, (ii) fluorescent labeling molecule 4-carbazole benzoic acid (CB), and (iii) a zirconium metal oxo-cluster labeled with CB, which is a photoresist candidate for extreme-ultraviolet lithography. Our results establish time-resolved XEOL as a new technique to measure transient XUV-driven phenomena in solid-state samples, and identify decay mechanisms of molecules following XUV and soft-X-ray excitation

Transport and the Order Parameter of Superconducting Sr2_2RuO4_4

Recent experiments make it appear more likely that the order parameter of the unconventional superconductor Sr$_2$RuO$_4$ has a spin-triplet $f$-wave symmetry. We study ultrasonic absorption and thermal conductivity of superconducting Sr$_2$RuO$_4$ and fit to the recent data for various $f$-wave candidates. It is shown that only $f_{x^2-y^2}$-wave symmetry can account qualitatively for the transport data.Comment: 4 pages, 2 figures, references added and update

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.

The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely the C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2, or C5L2). C5aR2 is a non-G-protein-signalling receptor whose biological role remains controversial. Some of this controversy arises owing to the lack of selective ligands for C5aR2. In this study, a library of 61 peptides based on the C-terminus of C5a was assayed for the ability to selectively modulate C5aR2 function. Two ligands (P32 and P59) were identified as functionally selective C5aR2 ligands, exhibiting selective recruitment of β-arrestin 2 via C5aR2, partial inhibition of C5a-induced ERK1/2 activation and lipopolysaccharide-stimulated interleukin-6 release from human monocyte-derived macrophages. Importantly, neither ligand could induce ERK1/2 activation or inhibit C5a-induced ERK1/2 activation via C5aR1 directly. Finally, P32 inhibited C5a-mediated neutrophil mobilisation in wild-type, but not C5aR2(-/-) mice. These functionally selective ligands for C5aR2 are novel tools that can selectively modulate C5a activity in vitro and in vivo, and thus will be valuable tools to interrogate C5aR2 function.Immunology and Cell Biology advance online publication, 17 May 2016; doi:10.1038/icb.2016.43