Inherited Groups and Kernels of Derived Translation Planes

When an affine plane is converted to another plane by derivation, the point permutations which act as collineations of both planes form the inherited group. The full group can be larger than the inherited group. For finite translation planes in which some of the Baer subplanes involved are not vector spaces over the kernel of the original plane then the full collineation group of the derived plane is the inherited group provided the order of the plane is greater than 16

Persuading consumers to reduce their consumption of electricity in the home

Previous work has identified that providing real time feedback or interventions to consumers can persuade consumers to change behaviour and reduce domestic electricity consumption. However, little work has investigated what exactly those feedback mechanisms should be. Most past work is based on an in-home display unit, possibly complemented by lower tariffs and delayed use of non-essential home appliances such as washing machines. In this paper we focus on four methods for real time feedback on domestic energy use, developed to gauge the impact on energy consumption in homes. Their feasibility had been tested using an experimental setup of 24 households collecting minute-by-minute electricity consumption data readings over a period of 18 months. Initial results are mixed, and point to the difficulties of sustaining a reduction in energy consumption, i.e. persuading consumers to change their behaviour. Some of the methods we used exploit small group social dynamics whereby people want to conform to social norms within groups they identify with. It may be that a variety of feedback mechanisms and interventions are needed in order to sustain user interest

Persuading Consumers to Reduce Their Consumption of Electricity in the Home

Previous work has identified that providing real time feedback or interventions to consumers can persuade consumers to change behaviour and reduce domestic electricity consumption. However, little work has investigated what exactly those feedback mechanisms should be. Most past work is based on an in-home display unit, possibly complemented by lower tariffs and delayed use of non-essential home appliances such as washing machines. In this paper we focus on four methods for real time feedback on domestic energy use, developed to gauge the impact on energy consumption in homes. Their feasibility had been tested using an experimental setup of 24 households collecting minute-by-minute electricity consumption data readings over a period of 18 months. Initial results are mixed, and point to the difficulties of sustaining a reduction in energy consumption, i.e. persuading consumers to change their behaviour. Some of the methods we used exploit small group social dynamics whereby people want to conform to social norms within groups they identify with. It may be that a variety of feedback mechanisms and interventions are needed in order to sustain user interest

Oncogenic Signaling Pathways in The Cancer Genome Atlas

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFb signaling, p53 and beta-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy