Total hepatectomy and liver replacement (orthotopic liver transplantation) for primary hepatic malignancy

There has been a high incidence of tumor recurrence after liver transplantation for primary hepatic malignancy. Nevertheless, a small but significant palliation has been possible with this approach, even in patients who eventually died of recurrence. Two patients with incidental malignancies in their excised livers apparently have been cured. Further gains will be possible only with extremely discriminating selection of prospective recipients. © 1982 Société Internationale de Chirurgie

Liver transplantation for biliary atresia

Orthotopic liver transplantation was performed 15 months to 20 years ago in 126 recipients, all of whom were under 18 years of age. Eighty-six of these pediatric recipients were treated before 1980 with azathioprine (or eyclophosphamide) and prednisone, to which antilymphocyte globulin (ALG) usually was added. One-year patient survival was 40%. In the last 40 cases, the new drug cyclosporine has been given with low doses of steroids. The one-year patient survival increased to 65%. Both in the pre-cyclosporine era and more recently, the survival of patients with biliary atresia has been lower than in the next largest category of patients, namely, those with liver-based inborn metabolic errors. The difficulty of operation in patients with biliary atresia has been greater than in recipients with other diagnoses, partly because of previous operations such as portoenterostomy (Kasai procedure). Hepatic portoenterostomy, worthwhile as it is, has posed technical difficulties for eventual liver transplantation, particularly when complicated Roux limb techniques or venting procedures have been applied. In our total experience the longest survival after liver replacement in a child whose original diagnosis was biliary atresia is 132/3 years. © 1984 Société Internationale de Chirurgie

The Intertwinement of Legal Orders : a Critical Reconstruction of Theories of Jurisprudence

My aim in this study is to make sense of the intertwinement of legal orders in European liberal democracies from the perspective of jurisprudence. Theories of jurisprudence may provide answers to theoretical questions that arise from the intertwinement of legal orders

Isolation and transmission of an unidentified Babesia sp. infective for cattle

Engorged adult female ticks submitted from farms in South Africa were routinely screened for protozoan parasites by examination of haemolymph smears. An unidentified Babesia sp. was found in Hyalomma marginatum rufipes and its transmission to susceptible cattle was achieved both biologically (tick feeding) and mechanically (injection of infected blood). Attempts to transmit this species to susceptible rabbits and a horse using similar methods did not produce evidence of infection. This Babesia sp. was of low pathogenicity, even in splenectomized cattle. Morphologically, intra-erythrocytic piroplasms and merozoites in tick haemolymph resembled other bovine Babesia spp. in many respects. Although it could be classified as a large Babesia, it was intermediate in size between the other species.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York

Improved effective mobility extraction in MOSFETs

The standard method of extracting carrier effective mobility from electrical measurements on MOSFETs is reviewed and the assumptions implicit in this method are discussed. A novel technique is suggested that corrects for the difference in drain bias during IV and CV measurements. It is further shown that the lateral field and diffusion corrections, which are both commonly neglected, in fact cancel. The effectiveness of the proposed technique is demonstrated by application to data measured on a quasi-planar SOI finFET at 300 K and 4 K

Systematic study of the influence of coherent phonon wave packets on the lasing properties of a quantum dot ensemble

Kohärente Phononen können die Licht-Materie-Wechselwirkung in Halbleiter Nanostrukturen stark ändern. Bei einem Ensemble von Quantenpunkten (QP) als aktivem Lasermedium sind Phononen im Stande, die Laserintensität deutlich zu verstärken oder abzuschwächen. Die Physik des gekoppelten Phonon-Exziton-Licht-Systems wird von verschiedenen Mechanismen dominiert, die im Experiment nicht eindeutig unterschieden werden können, da die komplizierte Probenstruktur zu einem komplexen Verspannungspuls führt, der auf das QP-Ensemble trifft. Hier zeigen wir durch eine umfassende theoretische Studie, wie die Laseremission durch Phononpulse verschiedener Form und QP-Ensembles verschiedener spektraler Verteilung beeinflusst wird. Dies erlaubt einen Einblick in die grundlegenden Wechselspiele des gekoppelten Gesamtsystems. Dadurch können wir zwischen zwei Mechanismen unterschieden: der adiabatischen Verschiebung des Ensembles und dem Schüttel-Effekt. Dies ebnet den Weg zu einer gezielten Kontrolle der Laser Emission durch kohärente Phononen.Coherent phonons can greatly vary light–matter interaction in semiconductor nanostructures placed inside an optical resonator on a picosecond time scale. For an ensemble of quantum dots (QDs) as active laser medium, phonons are able to induce a large enhancement or attenuation of the emission intensity, as has been recently demonstrated. The physics of this coupled phonon–exciton–light system consists of various effects, which in the experiment typically cannot be clearly separated, in particular, due to the complicated sample structure a rather complex strain pulse impinges on the QD ensemble. Here we present a comprehensive theoretical study how the laser emission is affected by phonon pulses of various shapes as well as by ensembles with different spectral distributions of the QDs. This gives insight into the fundamental interaction dynamics of the coupled phonon–exciton–light system, while it allows us to clearly discriminate between two prominent effects: the adiabatic shifting of the ensemble and the shaking effect. This paves the way to a tailored laser emission controlled by phonons.</p

Babesia, Theileria and Anaplasma spp. infecting sable antelope, Hippotragus niger (Harris, 1838), in southern Africa

Some observations are recorded on blood parasites of sable antelopes. Blood smears of 124 of these antelopes from South Africa and Zimbabwe were examined and 7 were found to be positive for a Babesia sp., identified as Babesia irvinesmithi Martinaglia 1936. A total of 70 of the smears were positive for Theilerial piroplasms, while 1 smear had macroschizonts (with cytomeres) and microschizonts of a Theileria (=Cytauxzoon) sp. One blood smear was positive for an Anaplasma sp. Attempts to isolate the Babesia sp. by subinoculating blood from sable to splenectomized and intact sable and splenectomized cattle were unsuccessful. Attempts to infect sable with Babesia bovis and Babesia bigemina were likewise unsuccessful. Theilerial piroplasms reached high levels in a splenectomized sable but could not be transmitted with blood to cattle. The Anaplasma sp. was found to be infective for sheep but not for cattle.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format