9 research outputs found

    Strengthening mechanisms in thermomechanically processed NbTi-microalloyed steel

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    The effect of deformation temperature on microstructure and mechanical properties was investigated for thermomechanically processed NbTi-microalloyed steel with ferrite-pearlite microstructure. With a decrease in the finish deformation temperature at 1348 K to 1098 K (1075 °C to 825 °C) temperature range, the ambient temperature yield stress did not vary significantly, work hardening rate decreased, ultimate tensile strength decreased, and elongation to failure increased. These variations in mechanical properties were correlated to the variations in microstructural parameters (such as ferrite grain size, solid solution concentrations, precipitate number density and dislocation density). Calculations based on the measured microstructural parameters suggested the grain refinement, solid solution strengthening, precipitation strengthening, and work hardening contributed up to 32 pct, up to 48 pct, up to 25 pct, and less than 3 pct to the yield stress, respectively. With a decrease in the finish deformation temperature, both the grain size strengthening and solid solution strengthening increased, the precipitation strengthening decreased, and the work hardening contribution did not vary significantly

    Environmental cognitions, land change, and social–ecological feedbacks : an overview

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    Understanding land use transitions requires analyzing how, when facing qualitative environmental change, human agents may modify their beliefs, values, and decision rules. This article first reviews some of the useful theories analyzing how environmental change can have a feedback effect on behaviors, via the environmental cognitions. Then, it discusses three propositions for more cognitively realistic agents in land change science: (i) land use choices result from multiple decision-making processes and rely on various motives, influenced by social norms, emotions, beliefs, and values toward the environment; (ii) social–ecological feedbacks are mediated by the environmental cognitions, that is, the perception, interpretation, evaluation of environmental change, and decision-making; (iii) human agents actively re-evaluate their beliefs, values, and functioning to adapt to unexpected environmental changes. Empirical and modeling studies in land change science can progress by linking the three components of the feedback loop, that is, environmental changes, environmental cognitions, and land use practices

    Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.

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    We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 × 10-9), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background
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