The Method of Fundamental Solutions for Direct Cavity Problems in EIT

The Method of Fundamental Solutions (MFS) is an effective technique for solving linear elliptic partial differential equations, such as the Laplace and Helmholtz equation. It is a form of indirect boundary integral equation method and a technique that uses boundary collocation or boundary fitting. In this paper the MFS is implemented to solve A numerically an inverse problem which consists of finding an unknown cavity within a region of interest based on given boundary Cauchy data. A range of examples are used to demonstrate that the technique is very effective at locating cavities in two-dimensional geometries for exact input data. The technique is then developed to include a regularisation parameter that enables cavities to be located accurately and stably even for noisy input data

A note on local well-posedness of generalized KdV type equations with dissipative perturbations

In this note we report local well-posedness results for the Cauchy problems associated to generalized KdV type equations with dissipative perturbation for given data in the low regularity $L^2$-based Sobolev spaces. The method of proof is based on the {\em contraction mapping principle} employed in some appropriate time weighted spaces.Comment: 14 page

Consistent cosmological structure formation on all scales in relativistic extensions of MOND

General relativity manifests very similar equations in different regimes, notably in large scale cosmological perturbation theory, non-linear cosmological structure formation, and in weak field galactic dynamics. The same is not necessarily true in alternative gravity theories, in particular those that possess MONDian behaviour (“relativistic extensions” of MOND). In these theories different regimes are typically studied quite separately, sometimes even with the freedom in the theories chosen differently in different regimes. If we wish to properly and fully test complete cosmologies containing MOND against the ΛCDM paradigm then we need to understand cosmological structure formation on all scales, and do so in a coherent and consistent manner. We propose a method for doing so and apply it to generalised Einstein-Aether theories as a case study. We derive the equations that govern cosmological structure formation on all scales in these theories and show that the same free function (which may contain both Newtonian and MONDian branches) appears in the cosmological background, linear perturbations, and non-linear cosmological structure formation. We show that MONDian behaviour on galactic scales does not necessarily result in MONDian behaviour on cosmological scales, and for MONDian behaviour to arise cosmologically, there will be no modification to the Friedmann equations governing the evolution of the homogeneous cosmological background. We comment on how existing N-body simulations relate to complete and consistent generalised Einstein-Aether cosmologies. The equations derived in this work allow consistent cosmological N-body simulations to be run in these theories whether or not MONDian behaviour manifests on cosmological scales

Toward a programmable software-defined IoT architecture for sensor service provision on demand

© 2017 IEEE. In the age of Internet of Things (IoT), sensors form a foundational component of IoT services, yet they are rigid with little capability for programmable configuration or reusability as they are application-specific, manufacturer-specific. Emerging IoT applications often deploy a vast number of sensors which may serve multiple applications. Programmability is thus essential but not found in legacy or current generation sensors. It is challenging to effectively utilize heterogeneity of resources to handle a large number of application demands. Software Defined Networking (SDN) and Network Function Virtualization (NFV) have proved effective paradigms for provisioning services on-demand and managing network functions and their life cycles. This paper proposes a software defined IoT architecture that captures the spirit of SDN and NFV where a software-defined Internet of Things (SD-IoT) controller can provide services as requested by an application and also manage heterogeneous physical sensors through their virtual representation called software-defined virtual sensor (SD-VSensor) autonomously. In particular, the paper presents the design of a streamline SD-IoT controller, a lightweight and reconfigurable SD-VSensor, and the communication protocol (S-MANAGE) between them. The proposed architecture enables heterogeneous application-specific WSN systems to be recognized and effectively utilized by diverse IoT applications under the orchestration of the SD-IoT controller. Moreover, heterogeneity of sensor nodes or IoT devices can be programmed to achieve sensor services on demand. The preliminary implementation results demonstrate the feasibility and efficiency of the proposed architecture

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.

A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of the ZAP-70 protein tyrosine kinase with the TCR complex. Human T cell leukemia virus type I-transformed CD4+ T cell lines were established from ZAP-70-deficient patients and normal controls. ZAP-70 was expressed and appropriately phosphorylated in normal T cell lines after TCR engagement, but was not detected in T cell lines from ZAP-70-deficient patients. To determine whether signaling could be reconstituted, wild-type ZAP-70 was introduced into deficient cells with a ZAP-70 retroviral vector. High titer producer clones expressing ZAP-70 were generated in the Gibbon ape leukemia virus packaging line PG13. After transduction, ZAP-70 was detected at levels equivalent to those observed in normal cells, and was appropriately phosphorylated on tyrosine after receptor engagement. The kinase activity of ZAP-70 in the reconstituted cells was also appropriately upregulated by receptor aggregation. Moreover, normal and transduced cells, but not ZAP-70-deficient cells, were able to mobilize calcium after receptor ligation, indicating that proximal TCR signaling was reconstituted. These results indicate that this form of SCID may be corrected by gene therapy

Tone perception in Mandarin-speaking school age children with otitis media with effusion

published_or_final_versio

The importance of sea ice area biases in 21st century multimodel projections of Antarctic temperature and precipitation

This is the final version of the article. Available from the publisher via the DOI in this record.Climate models exhibit large biases in sea ice area (SIA) in their historical simulations. This study explores the impacts of these biases on multimodel uncertainty in Coupled Model Intercomparison Project phase 5 (CMIP5) ensemble projections of 21st century change in Antarctic surface temperature, net precipitation, and SIA. The analysis is based on time slice climatologies in the Representative Concentration Pathway 8.5 future scenario (2070-2099) and historical (1970-1999) simulations across 37 different CMIP5 models. Projected changes in net precipitation, temperature, and SIA are found to be strongly associated with simulated historical mean SIA (e.g., cross-model correlations of r = 0.77, 0.71, and -0.85, respectively). Furthermore, historical SIA bias is found to have a large impact on the simulated ratio between net precipitation response and temperature response. This ratio is smaller in models with smaller-than-observed SIA. These strong emergent relationships on SIA bias could, if found to be physically robust, be exploited to give more precise climate projections for Antarctica.We acknowledge the World Climate Research Programme’s Working Group on Coupled Modelling, which is responsible for CMIP, and we thank the climate modeling groups (listed in Table S1 of this paper) for producing and making available their model output. For CMIP the U.S. Department of Energy’s Program for Climate Model Diagnosis and Intercomparison provided the coordinating support and led development of software infrastructure in partnership with the Global Organization for Earth System Science Portals. The original CMIP5 data can be accessed through the ESGF data portals (see http://pcmdi-cmip.llnl.gov/cmip5/ availability.html). This study is part of the British Antarctic Survey Polar Science for Planet Earth Programme. It was funded by The UK Natural Environment Research Council (grant reference NE/K00445X/1). We would like to thank Paul Holland for his useful discussions and comments on an earlier version of this manuscript

Compressibility of titanosilicate melts

The effect of composition on the relaxed adiabatic bulk modulus (K0) of a range of alkali- and alkaline earth-titanosilicate [X 2 n/n+ TiSiO5 (X=Li, Na, K, Rb, Cs, Ca, Sr, Ba)] melts has been investigated. The relaxed bulk moduli of these melts have been measured using ultrasonic interferometric methods at frequencies of 3, 5 and 7 MHz in the temperature range of 950 to 1600°C (0.02 Pa s < s < 5 Pa s). The bulk moduli of these melts decrease with increasing cation size from Li to Cs and Ca to Ba, and with increasing temperature. The bulk moduli of the Li-, Na-, Ca- and Ba-bearing metasilicate melts decrease with the addition of both TiO2 and SiO2 whereas those of the K-, Rb- and Cs-bearing melts increase. Linear fits to the bulk modulus versus volume fraction of TiO2 do not converge to a common compressibility of the TiO2 component, indicating that the structural role of TiO2 in these melts is dependent on the identity of the cation. This proposition is supported by a number of other property data for these and related melt compositions including heat capacity and density, as well as structural inferences from X-ray absorption spectroscopy (XANES). The compositional dependence of the compressibility of the TiO2 component in these melts explains the difficulty incurred in previous attempts to incorporate TiO2 in calculation schemes for melt compressibility. The empirical relationship KV-4/3 for isostructural materials has been used to evaluate the compressibility-related structural changes occurring in these melts. The alkali metasilicate and disilicate melts are isostructural, independent of the cation. The addition of Ti to the metasilicate composition (i.e. X2TiSiO5), however, results in a series of melts which are not isostructural. The alkaline-earth metasilicate and disilicate compositions are not isostructural, but the addition of Ti to the metasilicate compositions (i.e. XTiSiO5) would appear, on the basis of modulus-volume systematics, to result in the melts becoming isostructural with respect to compressibility

Malignant Struma Ovarii: Case Report and a Review of the Literature

Struma ovarii is a rare tumor. Malignant change in this tumour is even rarer. While clinical presentation is protean, a preoperative diagnosis is equally difficult. Diagnosis is confirmed by histology. Treatment ofmalignant struma ovarii is by surgical resection of the tumor or total abdominal hysterectomy and bilateral salpingo-oophorectomy. A total thyroidectomy allows radioactive iodine ablation and the use of thyroglobulin as marker to monitor recurrence. However due to rarity of the disease, standard treatment is still controversial. We present a case of malignant struma ovarii, followed up for five years after treatment, and a review of the literature on the disease. The patient was treated with surgery and radiation. She is still free of disease after 5 years.Key Words: Malignant Struma Ovarii, Ovarian Teratoma, Papillary Thyroid Carcinom