Mathematical model of coordination number of spherical packing

The article considers a mathematical model of the coordination number, which allows obtaining an equation for multi component spherical packing in the entire range of its change. The resulting model can be used in both 2-d and 3-d spaces. The concept of the coordination index is introduced as a function of the inter-particle distance related to a single particle located near the central particle. The model provides unambiguous compliance between the simulated and calculated data on the coordination numbers of the spherical packin

Structure and properties of lymphocytes’ surfaces in patients with chronic lymphoblastic leucosis

In the investigation that was performed, the authors studied the structure and properties of lymphocytes’ surfaces in patients with chronic lymphoblastic leukemia with application of atomic force microscopy technology. It was stated that development of chronic lymphoblastic leukemia is characterized with circulation of immature forms of lymphocytic series in peripheral bloodstream, for which increase of surface potential by 456% (p<0.05) as compared with control group, is typica

Features of human papillomavirus infection frequency in different regions of the Russian Federation (literature review)

Numerous studies have shown the role of human papillomavirus (HPV) in the generation of cervical cancer. The review presents Russian researching data aboutfrequency of the HPV in different regions of the Russian Federation. The regional feature in the frequency of the HPV is observed. The average population frequency of the HPV varies from 13 to 63 % in different region. The frequency of the HPV reaches 82 % in groups of patients with dysplasia of the 3rd degree and cervical cancer. The most oncogenic type 16 the HPV is the most common virus among other papillomavirus in the most Russian regions that corresponds to the global data. This type of virus is the most common in both groups of women and men. Type 16 of HPV with high frequency is detected in different age groups, and among clinically healthy patients and in groups of patients with various gynecological pathologies. Modern methods of molecular diagnostics, in particular, the PCR method, allow to detect and genotype the HPV with high sensitivity and specificity, and to determine the viral load. The PCR method in screening programs can identify risk groups of the urogenital pathology in examined women

Glutathione S-transferase polymorphism in ethnic groups living in Eastern Siberia

The role of glutathione S-transferase for the life of the cell and the entire organism is related to their participation in the processes of detoxification of xenobiotics and antioxidant protection. Genetic variability of glutathione S-transferases appears in the form of different enzymatic activity of the corresponding protein products. In this study, a comparative analysis was conducted on the frequency of genotypes of three genes in the glutathione S-transferases gene superfamily (GSTM1, GSTT1, GSTP1) from representatives of two ethnic groups, Russian and Buryat. To this end, genetic typing of DNA samples was performed by polymerase chain reaction. Statistically significant differences in the frequency of occurrence of alleles A, B, C of the GSTP1 gene (р = 0.026) were found between the groups of teenagers compared. It was found that the frequency of the allele A, which codes for the active variant enzyme, is significantly higher in the Buryat ethnic group (p = 0.012). The allele B, the product of which is a “slow” version of the enzyme, was significantly more common in the Russian ethnic group (p = 0.014). In the GSTM1 and GSTT1 genes, no statistically significant differences in the frequency of occurrence of “zero” and “functional” genotypes between the compared groups of teenagers were found. However, there was a tendency to increase in the frequency of the “zero” genotype of the GSTM1 gene in the Russian ethnic group. In addition, the frequency of the “zero” genotype in two genes GSTM1 and GSTT1 at once was almost two times higher in the Russian ethnic group than in the Buryat ethnic group

Filaggrin gene polymorphisms are associated with atopic dermatitis in women but not in men in the Caucasian population of Central Russia

This study aimed to analyze the gender-specific association of the filaggrin (FLG) gene polymorphisms with atopic dermatitis in Caucasians from the central region of Russi

Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia

Association of the filaggrin (FLG) gene with atopic dermatitis (AD) in Caucasians from Central Russia was studiedin the sample of 700 patients and 612 controls. The biological process enrichment analyses suggest that the target AD candidate genes influence the formation of the cornified envelope, keratinization and cornification, and more than twenty other pathways related to skin development, programmed cell death, and regulation of water loss via ski

FREQUENCY OF HUMAN PAPILLOMA VIRUS IN IRKUTSK POPULATION

Background. In the regions of the Russian Federation (RF), papillomavirus infection in women of reproductive age is characterized by different frequency of occurrence from 13 to 68.4 %. Aims: to establish the frequency of detection of human papilloma virus in Irkutsk, according to the data of circulation. Materials and methods. The article presents the results of the medical examination of residents of Irkutsk on the presence DNA of human papilloma virus. We analyzed the results of laboratory studies of patients who from 2014 to 2016 turned to the medical institution for the diagnosis of human papilloma virus. For the period surveyed was 13 090 man, age from 18 to 67 years, including 11 174 women and 1 916 male. The diagnosis of HPV was carried out by polymerase chain reaction (PCR). Results. It was found the frequency of HPV in Irkutsk in the general population is 21.1 %, among women – 21.9 %, among male – 16.4 %. It was shown that the frequency of detection of papillomavirus infection in the sample of women was significantly higher than in the sample of men (p &lt; 0.001).Conclusions: It was shown that the frequency of HPV is 21.1 % the frequency of detection of the pathogen of papillomavirus infection in the sample of women was significantly higher (p &lt; 0.001) than in the sample of male

Possible Existence of Neutron-Proton Halo in 6Li

One of the most recent results was the determination of the proton halo in the first excited state of the 13N nucleus using of an analog of the MDM method for the charge exchange reactions (3He, t). It turned out that this state has the same radius as the mirror state 1/2+, 3.09 MeV in 13C.This observation allows us to take the next step and try to apply this approach to measure the radii of states. The increased radii in the isobar - analogue states of the 6He-6Li-6Be triplet, which may also have a halo structure, are not excluded. As a first step, we analyzed the published differential cross sections for inelastic scattering of 3He + 6Li with the excitation of the 2.19 MeV, 3+ state at energies 34 and 72 MeV and 3.56 MeV, 0+ state at energies 24.6 and 27 MeV. Probably the state 0+, 3.56 MeV has the same radius as its ”Borromian” isobar analogue 6He and is neutron-proton halo. The predicted enlarged radius because of the more extended wave function p - n, apparently, does not take place. We recall that the spatial structure of the 6He nucleus was predicted to be quite complex, in which correlations of two types appeared: ”cigar” and ”dineutron”. The question arises: does the structure of the state change so much when passing from 6He to the isobar-analoguein6Li,whichrequirestheintroductionofaspecialkindof“tango-halo”