Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia

Abstract

Association of the filaggrin (FLG) gene with atopic dermatitis (AD) in Caucasians from Central Russia was studiedin the sample of 700 patients and 612 controls. The biological process enrichment analyses suggest that the target AD candidate genes influence the formation of the cornified envelope, keratinization and cornification, and more than twenty other pathways related to skin development, programmed cell death, and regulation of water loss via ski

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