Comment: Microarrays, Empirical Bayes and the Two-Groups Model

Comment on ``Microarrays, Empirical Bayes and the Two-Groups Model'' [arXiv:0808.0572]Comment: Published in at http://dx.doi.org/10.1214/07-STS236A the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Cosmic Ray Spallation in Radio-Quiet Active Galactic Nuclei: A Case Study of NGC 4051

We investigate conditions for and consequences of spallation in radio-quiet Seyfert galaxies. The work is motivated by the recent discovery of significant line emission at 5.44 keV in Suzaku data from NGC 4051. The energy of the new line suggests an identification as Cr I Ka emission, however the line is much stronger than would be expected from material with cosmic abundances, leading to a suggestion of enhancement owing to nuclear spallation of Fe by low energy cosmic rays from the active nucleus. We find that the highest abundance enhancements are likely to take place in gas out of the plane of the accretion disk and that timescales for spallation could be as short as a few years. The suggestion of a strong nuclear flux of cosmic rays in a radio-quiet Seyfert galaxy is of particular interest in light of the recent suggestion from Pierre Auger Observatory data that ultra-high-energy cosmic rays may originate in such sources.Comment: 14 pages, 1 figure. Accepted for publication in The Astrophysical Journa

Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid

Exposure to valproic acid (VPA) during embryogenesis can cause several teratogenic effects, including developmental delays and in particular autism in humans if exposure occurs during the third week of gestation. We examined the postnatal effects of embryonic exposure to VPA on microcircuit properties of juvenile rat neocortex using in vitro electrophysiology. We found that a single prenatal injection of VPA on embryonic day 11.5 causes a significant enhancement of the local recurrent connectivity formed by neocortical pyramidal neurons. The study of the biophysical properties of these connections revealed weaker excitatory synaptic responses. A marked decrease of the intrinsic excitability of pyramidal neurons was also observed. Furthermore, we demonstrate a diminished number of putative synaptic contacts in connection between layer 5 pyramidal neurons. Local hyperconnectivity may render cortical modules more sensitive to stimulation and once activated, more autonomous, isolated, and more difficult to command. This could underlie some of the core symptoms observed in humans prenatally exposed to valproic aci

Self-trapped bidirectional waveguides in a saturable photorefractive medium

We introduce a time-dependent model for the generation of joint solitary waveguides by counter-propagating light beams in a photorefractive crystal. Depending on initial conditions, beams form stable steady-state structures or display periodic and irregular temporal dynamics. The steady-state solutions are non-uniform in the direction of propagation and represent a general class of self-trapped waveguides, including counterpropagating spatial vector solitons as a particular case.Comment: 4 pages, 5 figure

Spatiotemporal pulses in a liquid crystal optical oscillator

A nonlinear optical medium results by the collective orientation of liquid crystal molecules tightly coupled to a transparent photoconductive layer. We show that such a medium can give a large gain, thus, if inserted in a ring cavity, it results in an unidirectional optical oscillator. Dynamical regimes with many interacting modes are made possible by the wide transverse size and the high nonlinearity of the liquid crystals. We show the generation of spatiotemporal pulses, coming from the random superposition of many coexisting modes with different frequencies

Behavior of Sodium Oxide, Uranium Oxide and Mixed Sodium Oxide-Uranium Oxide Aerosols in a Large Vessel

Results are reported for experiments on the behavior of sodium oxide aerosols, uranium oxide aerosols, and various mixtures of these in the Nuclear Safety Pilot Plant (NSPP) vessel at Oak Ridge National Laboratory. The NSPP program, sponsored by the Nuclear Regulatory Commission, is to provide experimental qualification of the HAARM-3 aerosol behavioral code being independently developed at Battelle-Columbus Laboratories. The results of fourteen single-component and six mixed-component aerosol experiments are presented along with selected comparisons with code predictions

The Origin of Galactic Cosmic Rays

Motivated by recent measurements of the major components of the cosmic radiation around 10 TeV/nucleon and above, we discuss the phenomenology of a model in which there are two distinct kinds of cosmic ray accelerators in the galaxy. Comparison of the spectra of hydrogen and helium up to 100 TeV per nucleon suggests that these two elements do not have the same spectrum of magnetic rigidity over this entire region and that these two dominant elements therefore receive contributions from different sources.Comment: To be published in Physical Review D, 13 pages, with 3 figures, uuencode

Fission-Residues Produced in the Spallation Reaction 238U+p at 1 A GeV

Fission fragments from 1 A GeV 238U projectiles irradiating a hydrogen target were investigated by using the fragment separator FRS for magnetic selection of reaction products including ray-tracing and DE-ToF techniques. The momentum spectra of 733 identified fragments were analysed to provide isotopic production cross sections, fission-fragment velocities and recoil momenta of the fissioning parent nuclei. Besides their general relevance, these quantities are also demanded for applications. Calculations and simulations with codes commonly used and recently developed or improved are compared to the data.Comment: 60 pages, 21 figures, 4 tables, 2 appendices (15 pages

Spatiotemporally localized solitons in resonantly absorbing Bragg reflectors

We predict the existence of spatiotemporal solitons (``light bullets'') in two-dimensional self-induced transparency media embedded in a Bragg grating. The "bullets" are found in an approximate analytical form, their stability being confirmed by direct simulations. These findings suggest new possibilities for signal transmission control and self-trapping of light.Comment: RevTex, 3 pages, 2 figures, to be published in PR