Нарушение структурных липидов в патогенезе бронхиальной астмы

A comparative investigation of structural lipids in blood cells and low and high density lipoproteins was done in blood samples of 88 patients with different types of bronchial asthma and in 40 donors. Modifications of phospholipid spectrum were determined in the blood cells and the lipoproteins of asthma patients. The abnormality was expressed as a change in ratio between individual phospholipids which was connected with a significant deficiency of the main membrane phospholipid phosphathidylcholine and with increased level of its lysoform lysophosphathidylcholin. These modifications in the structural lipids allow to consider asthma as membrane pathology. We used different types of treatment such as glucocorticosteroids, diet, methylxanthines, adrenergic drugs. Positive effects on the lipoproteins were reached against the background of glucocorticosteroids and dietary therapy. The phospholipid modifications in the blood cells was conservative in all the used methods of treatment.Проведено сравнительное исследование состава структурных липидов в форменных элементах (ФЭ) и липопротеидах (ЛП) низкой (ЛПНП) и высокой (ЛПВП) плотности в крови 88 больных бронхиальной астмой (БА) смешанного генеза и 40 доноров. Установлено нарушение спектра фосфолипидов (ФЛ) как в ФЭ, так и ЛП у пациентов с БА. Отклонение от нормы сводилось к изменению соотношения в индивидуальны х ФЛ, что связано со значительным дефицитом у больных основного мембранного фосфолипида — фосфатидилхолина (ФХ) и повышением уровня его лизоформы — лизофосфатидилхолина (ЛФХ). Происходящие перестройки в структурных липидах позволяют отнести БА к патологии с мембранными нарушениями. В исследовании использовались различные методы лечения: глюкокортикостероиды (ГКС), разгрузочно-диетическая терапия (РДТ) и базисная терапия метил ксантином и ингаляциями адреномиметика. Положительные эффекты в ЛП сыворотки достигались при ГКС и РДТ. Нарушенный спектр ФЛ в ФЭ крови больных оставался консервативным при различных видах лечения

Pan-Eurasian Experiment (PEEX): Towards a holistic understanding of the feedbacks and interactions in the land-Atmosphere-ocean-society continuum in the northern Eurasian region

The northern Eurasian regions and Arctic Ocean will very likely undergo substantial changes during the next decades. The Arctic-boreal natural environments play a crucial role in the global climate via albedo change, carbon sources and sinks as well as atmospheric aerosol production from biogenic volatile organic compounds. Furthermore, it is expected that global trade activities, demographic movement, and use of natural resources will be increasing in the Arctic regions. There is a need for a novel research approach, which not only identifies and tackles the relevant multi-disciplinary research questions, but also is able to make a holistic system analysis of the expected feedbacks. In this paper, we introduce the research agenda of the Pan-Eurasian Experiment (PEEX), a multi-scale, multi-disciplinary and international program started in 2012 (https://www.atm.helsinki.fi/peex/). PEEX sets a research approach by which large-scale research topics are investigated from a system perspective and which aims to fill the key gaps in our understanding of the feedbacks and interactions between the land-Atmosphere-Aquatic-society continuum in the northern Eurasian region. We introduce here the state of the art for the key topics in the PEEX research agenda and present the future prospects of the research, which we see relevant in this context