514 research outputs found
Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis
Although proton pump inhibitors (PPI) have a record of remarkable effectiveness and safety in the management of gastroesophageal reflux disease (GERD), several treatment challenges with PPI have emerged. Dexlansoprazole MR is the (R)-enantiomer of lansoprazole contained in a formulation that produces two distinct releases of drug and significantly extends the duration of active plasma concentrations and % time pH > 4 beyond that of conventional single-release PPI. Dexlansoprazole MR can be administered without regard to meals or the timing of meals in most patients. Dexlansoprazole MR 60 mg demonstrated similar efficacy for healing of erosive esophagitis at 8 weeks compared with lansoprazole 30 mg, and dexlansoprazole MR 30 mg was superior to placebo for maintenance of healed erosive esophagitis at 6 months with 99% of nights and 96% of days heartburn-free over 6 months in patients taking dexlansoprazole MR 30 mg. Superior relief of heartburn occurred in patients taking dexlansoprazole MR 30 mg (55% heartburn-free 24-hour periods) vs placebo (14%) for symptomatic nonerosive GERD. The safety profile of dexlansoprazole MR is similar to that of lansoprazole. The extended pharmacodynamic effects, added convenience, and efficacy and safety of dexlansoprazole MR offer a novel approach to gastric pH control in patients with acid-related disorders
A conceptual framework for the future of sea-level rise and land uplift changes in the Vaasa region of Finland
This paper uses the Vaasa region of Finland as an illustrative case study to explore how the relationships between climate change, sea-level rise and land uplift may offer applications in forecasting future land uplift changes. Using a comparative literature review and analysis of open source data, a conceptual framework is developed to ex-amine causes-effect relationships between them. The sea-level rise around the world by the end of the 21st century shows dramatic effects all over the world. However, the rate of land uplift in the Vaasa region is higher than the rate of sea-level rise. This localised finding is different from global average rates for land uplift and sea-level rise. This indicates that although climate change is global, it can lead to very different regional expressions. This paper presents a first attempt to combine sea-level rise and land uplift into a single cohesive framework to sup-port future land uplift management. The results of this paper establish a conceptual framework for studies of vulnerability and adaptation to climate change that can ben-efit local, regional and global communities
Impaired osteoclast homeostasis in the cystatin B-deficient mouse model of progressive myoclonus epilepsy
Peer reviewe
Shape coexistence at the proton drip-line: First identification of excited states in 180Pb
Excited states in the extremely neutron-deficient nucleus, 180Pb, have been
identified for the first time using the JUROGAM II array in conjunction with
the RITU recoil separator at the Accelerator Laboratory of the University of
Jyvaskyla. This study lies at the limit of what is presently achievable with
in-beam spectroscopy, with an estimated cross-section of only 10 nb for the
92Mo(90Zr,2n)180Pb reaction. A continuation of the trend observed in 182Pb and
184Pb is seen, where the prolate minimum continues to rise beyond the N=104
mid-shell with respect to the spherical ground state. Beyond mean-field
calculations are in reasonable correspondence with the trends deduced from
experiment.Comment: 5 pages, 4 figures, submitted to Phys.Rev.
First observation of excited states in 173Hg
The neutron-deficient nucleus 173Hg has been studied following
fusion-evaporation reactions. The observation of gamma rays decaying from
excited states are reported for the first time and a tentative level scheme is
proposed. The proposed level scheme is discussed within the context of the
systematics of neighbouring neutron-deficient Hg nuclei. In addition to the
gamma-ray spectroscopy, the alpha decay of this nucleus has been measured
yielding superior precision to earlier measurements.Comment: 5 pages, 4 figure
Search for Fingerprints of Tetrahedral Symmetry in
Theoretical predictions suggest the presence of tetrahedral symmetry as an
explanation for the vanishing intra-band E2-transitions at the bottom of the
odd-spin negative parity band in . The present study reports on
experiment performed to address this phenomenon. It allowed to determine the
intra-band E2 transitions and branching ratios B(E2)/B(E1) of two of the
negative-parity bands in .Comment: presented by Q.T. Doan at XLII Zakopane School of Physics: Breaking
Frontiers: Submicron Structures in Physics and Biology, May 2008. 5 pages,
minor corrections. To be published in the proceeding
Sources of pro-cyclicality in east Asian financial systems
Procyclicality is a normal feature of economic systems, but financial sector
weaknesses can exacerbate it sufficiently to pose a threat to macroeconomic and financial
stability. These include shortcomings in bank risk management and governance, in
supervision and in terms of dependence on volatile sources of funds. The paper tests
econometrically for the importance of such features leading to pro-cyclicality in the financial
systems of 11 East Asian countries. This analysis makes it possible to identify specific policy
measures for East Asian countries that could limit the extent to which financial systems
exacerbate pro-cyclicality
Long-Term Quality of Life Improvement in Subjects with Healed Erosive Esophagitis: Treatment with Lansoprazole
Gastroesophageal reflux disease (GERD) is a chronic symptomatic condition and may be associated with erosive esophagitis (EE). Considerable data on the long-term maintenance of healing of EE are available, but data on long-term GERD symptom prevention and patient quality of life (QOL) are limited.
To investigate QOL in subjects with healed EE who received 12 months of double-blind maintenance treatment with lansoprazole or ranitidine, followed by long-term open-label lansoprazole therapy to prevent recurrence of EE.
Subjects with healed EE received 12 months of double-blind maintenance treatment with lansoprazole 15 mg once daily or ranitidine 150 mg twice daily, followed by dose-titrated, open-label lansoprazole therapy for up to 82 months.
During double-blind treatment (n = 206), lansoprazole-treated patients showed significantly (P †0.05) greater improvements than ranitidine-treated patients in the frequency, severity, and âbothersomenessâ of heartburn, the symptom index, problems of activity limitation, eating and drinking problems, symptom problems, health distress, and social functioning. During dose-titrated, open-label treatment (n = 195), all disease-specific QOL scales except sleep improved significantly (P < 0.001) from open-label baseline at each time-point.
Maintenance treatment with lansoprazole for 12 months in healed EE subjects produced significantly greater improvements in QOL indicators than ranitidine. These improvements were sustained during dose-titrated, open-label lansoprazole treatment
A Fibreoptic Endoscopic Study of Upper Gastrointestinal Bleeding at Bugando Medical Centre in Northwestern Tanzania: a Retrospective Review of 240 Cases.
Upper gastrointestinal (GI) bleeding is recognized as a common and potentially life-threatening abdominal emergency that needs a prompt assessment and aggressive emergency treatment. A retrospective study was undertaken at Bugando Medical Centre in northwestern Tanzania between March 2010 and September 2011 to describe our own experiences with fibreoptic upper GI endoscopy in the management of patients with upper gastrointestinal bleeding in our setting and compare our results with those from other centers in the world. A total of 240 patients representing 18.7% of all patients (i.e. 1292) who had fibreoptic upper GI endoscopy during the study period were studied. Males outnumbered female by a ratio of 2.1:1. Their median age was 37 years and most of patients (60.0%) were aged 40 years and below. The vast majority of the patients (80.4%) presented with haematemesis alone followed by malaena alone in 9.2% of cases. The use of non-steroidal anti-inflammatory drugs, alcohol and smoking prior to the onset of bleeding was recorded in 7.9%, 51.7% and 38.3% of cases respectively. Previous history of peptic ulcer disease was reported in 22(9.2%) patients. Nine (3.8%) patients were HIV positive. The source of bleeding was accurately identified in 97.7% of patients. Diagnostic accuracy was greater within the first 24 h of the bleeding onset, and in the presence of haematemesis. Oesophageal varices were the most frequent cause of upper GI bleeding (51.3%) followed by peptic ulcers in 25.0% of cases. The majority of patients (60.8%) were treated conservatively. Endoscopic and surgical treatments were performed in 30.8% and 5.8% of cases respectively. 140 (58.3%) patients received blood transfusion. The median length of hospitalization was 8 days and it was significantly longer in patients who underwent surgical treatment and those with higher Rockall scores (P < 0.001). Rebleeding was reported in 3.3% of the patients. The overall mortality rate of 11.7% was significantly higher in patients with variceal bleeding, shock, hepatic decompensation, HIV infection, comorbidities, malignancy, age > 60 years and in patients with higher Rockall scores and those who underwent surgery (P < 0.001). Oesophageal varices are the commonest cause of upper gastrointestinal bleeding in our environment and it is associated with high morbidity and mortality. The diagnostic accuracy of fibreoptic endoscopy was related to the time interval between the onset of bleeding and endoscopy. Therefore, it is recommended that early endoscopy should be performed within 24 h of the onset of bleeding
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