Detection of the old stellar component of the major Galactic bar

We present near-IR colour--magnitude diagrams and star counts for a number of regions along the Galactic plane. It is shown that along the l=27 b=0 line of sight there is a feature at 5.7 +-0.7kpc with a density of stars at least a factor two and probably more than a factor five times that of the disc at the same position. This feature forms a distinct clump on an H vs. J-H diagram and is seen at all longitudes from the bulge to about l=28, but at no longitude greater than this. The distance to the feature at l=20 is about 0.5kpc further than at l=27 and by l=10 it has merged with, or has become, the bulge. Given that at l=27 and l=21 there is also a clustering of very young stars, the only component that can reasonably explain what is seen is a bar with half length of around 4kpc and a position angle of about 43+-7.Comment: 5 pages, 5 figures accepted as a letter in MNRA

Interleukin-17 as a Therapeutic Target in Psoriasis

A psoríase é uma doença crónica, inflamatória, imunomediada que afecta cerca de 1-3% da população geral. O avanço no conhecimento da patogénese da psoríase levou ao desenvolvimento de novos fármacos direccionados para vias imunitárias mais específicas que os existentes. A IL-17 e os linfócitos Th17 têm um importante papel na patogénese de várias doenças auto-imunes e imunomediadas, incluindo a psoríase. A IL-17A é uma citocina pró-inflamatória, produzida pelos linfócitos Th17 juntamente com outras citocinas efetoras, como a IL-17F e IL-22. Esta citocina é igualmente expressa por outras células do sistema imune inato, incluíndo os mastócitos, neutrófilos e células dendríticas, todas elas encontradas nas lesões de psoríase. Por esta razão a IL-17 surgiu como um alvo terapêutico potencial. Vários agentes que inibem a IL-17 estão em desenvolvimento e os resultados clínicos preliminares são bastante promissores, confirmando a importância da IL-17 na fisiopatologia da psoríase. A intervenção selectiva no sistema imune desta nova classe de agentes biotecnológicos, torna-os uma abordagem terapêutica interessante no controlo de doenças auto-imunes e imunomediadas, como na psoríase. Num futuro próximo, estas novas terapêuticas poderão constituir uma alternativa válida aos agentes biológicos actualmente disponíveis.Os autores declaram não terem existido fontes de financiamento externas na realização deste trabalho

Time-resolved spectroscopy of the pulsating CV GW Lib

We present time-resolved optical spectroscopy of the dwarf nova GW Librae during its rare 2007 April superoutburst and compare these with quiescent epochs. The data provide the first opportunity to track the evolution of the principal spectral features. In the early stages of the outburst, the optically thick disc dominates the optical and the line components show clear orbital radial velocity excursions. In the course of several weeks, optically thin regions become more prominent as strong emission lines replace the broad disc absorption. Post-outburst spectroscopy covering the I band illustrates the advantages of Ca II relative to the commonly used Balmer lines when attempting to constrain binary parameters. Due to the lower ionization energy combined with smaller thermal and shear broadening of these lines, a sharp emission component is seen to be moving in between the accretion disc peaks in the Ca II line. No such component is visible in the Balmer lines. We interpret this as an emission component originating on the hitherto unseen mass donor star. This emission component has a mean velocity of similar to -15 +/- 5 km s(-1) which is associated with the systemic velocity., and a velocity semi-amplitude of K-em = 82.2 +/- 4.9 km s(-1). Doppler tomography reveals an asymmetric accretion disc, with the S-wave mapping to a sharp spot in the tomogram with a velocity consistent to what is obtained with line profile fitting. A centre of symmetry analysis of the disc component suggests a very small value for the WD orbital velocity K-1 as is also inferred from double Gaussian fits to the spectral lines. While our conservative dynamical limits place a hard upper limit on the binary mass ratio of q < 0.23, we favour a significantly lower value near q similar to 0.06. Pulsation modelling suggests a white dwarf mass similar to 1 M-circle dot. This, paired with a low-mass donor, near the empirical sequence of an evolved cataclysmic variable close to the period bounce, appears to be consistent with all the observational constraints to date

Quantum Electrodynamics vacuum polarization solver

The self-consistent modeling of vacuum polarization due to virtual electron-positron fluctuations is of relevance for many near term experiments associated with high intensity radiation sources and represents a milestone in describing scenarios of extreme energy density. We present a generalized finite-difference time-domain solver that can incorporate the modifications to Maxwell's equations due to vacuum polarization. Our multidimensional solver reproduced in one dimensional configurations the results for which an analytic treatment is possible, yielding vacuum harmonic generation and birefringence. The solver has also been tested for two-dimensional scenarios where finite laser beam spot sizes must be taken into account. We employ this solver to explore different types of counter-propagating configurations that can be relevant for future planned experiments aiming to detect quantum vacuum dynamics at ultra-high electromagnetic field intensities

Radio sources in the Chandra Galactic Bulge Survey

We discuss radio sources in the Chandra Galactic Bulge Survey region. By cross-matching the X-ray sources in this field with the NRAO VLA Sky Survey archival data, we find 12 candidate matches. We present a classification scheme for radio/X-ray matches in surveys taken in or near the Galactic plane, taking into account other multiwavelength data. We show that none of the matches found here is likely to be due to coronal activity from normal stars because the radio to X-ray flux ratios are systematically too high. We show that one of the source could be a radio pulsar, and that one could be a planetary nebula, but that the bulk of the sources are likely to be background active galactic nuclei (AGN), with many confirmed through a variety of approaches. Several of the AGN are bright enough in the near-infrared (and presumably in the optical) to use as probes of the interstellar medium in the inner Galaxy

The light curve of the companion to PSR B1957+20

We present a new analysis of the light curve for the secondary star in the eclipsing binary millisecond pulsar system PSR B1957+20. Combining previous data and new data points at minimum from the Hubble Space Telescope, we have 100% coverage in the R-band. We also have a number of new K_s-band data points, which we use to constrain the infrared magnitude of the system. We model this with the Eclipsing Light Curve code (ELC). From the modelling with the ELC code we obtain colour information about the secondary at minimum light in BVRI and K. For our best fit model we are able to constrain the system inclination to 65 +/- 2 degrees for pulsar masses ranging from 1.3 -- 1.9 M_sun. The pulsar mass is unconstrained. We also find that the secondary star is not filling its Roche lobe. The temperature of the un-irradiated side of the companion is in agreement with previous estimates and we find that the observed temperature gradient across the secondary star is physically sustainable.Comment: 6 pages, 4 figures & 3tables. Accepted for publication in MNRA

Bullion production in imperial China and its significance for sulphide ore smelting world-wide

Gold and silver production was of major importance for almost all ancient societies but has been rarely studied archaeologically. Here we present a reconstruction of a previously undocumented technology used to recover gold, silver and lead at the site of Baojia in Jiangxi province, China dated between the 7th and 13th centuries AD. Smelting a mixture of sulphidic and gossan ores in a relatively low temperature furnace under mildly reducing conditions, the process involved the use of metallic iron to reduce lead sulphide to lead metal, which acted as the collector of the precious metals. An experimental reconstruction provides essential information, demonstrating both the significant influence of sulphur on the silicate slag system, and that iron reduction smelting of lead can be carried out at a relatively low temperature. These new findings are relevant for further studies of lead and precious metal smelting slags world-wide. The technological choices of ancient smelters at this site are then discussed in their specific geographical and social-economic settings