Four futures for energy markets and climate change

Future developments in energy and climate are highly uncertain. In order to deal with these uncertainties, we developed four long-term scenarios based on the recently published economic scenarios Four Futures of Europe: STRONG EUROPE, GLOBAL ECONOMY, TRANSATLANTIC MARKET and REGIONAL COMMUNITIES. In this study, we explore the next four decades. Although the report focuses on Europe, global aspects of energy use and climate change play a significant role. The next decades, global reserves of oil and natural gas will likely be sufficient to meet the growing demand. Therefore, there is no need to worry about a looming depletion of natural energy resources. The use of fossil energy carriers will, however, affect climate because of the emissions of greenhouse gasses. In order to mitigate global increases of temperature, emissions of greenhouse gasses should be reduced. Developing countries should contribute to that effort. On the one hand they will be major emitters in the near future, on the other hand they have the low-cost abatement options.

‘In een vrije markteconomie geniet het individu echte vrijheid..?’ (1): een visie op de vrije markt door de Libertarische Partij

Toine Manders is verbonden aan HJC Group. HJC Group is gespecialiseerd in belastingontwijking, estate planning, vermogensbescherming en oprichting en beheer van vennootschappen voor ondernemers, consultants en vermogende particulieren. Daarnaast is hij voorzitter van de Libertarische Partij. De LP streeft naar onbeperkte economische vrijheid en onbeperkte persoonlijke vrijheid van het individu, en is principieel tegen staatsmonopolies, belastingheffing en regulering

Applying model transformation and Event-B for specifying an industrial DSL

In this paper we describe our experience in applying the Event-B formalism for specifying the dynamic semantics of a real-life industrial DSL. The main objective of this work is to enable the industrial use of the broad spectrum of specification analysis tools that support Event-B. To leverage the usage of Event-B and its analysis techniques we developed model transformations, that allowed for automatic generation of Event-B specifications of the DSL programs. The model transformations implement a modular approach for specifying the semantics of the DSL and, therefore, improve scalability of the specifications and the reuse of their verification. Keywords: domain specific language, Event-B, model transformations, verification and validation, reuse, scalabilit

The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy

The growth and metastasising capacity of solid tumours are dependent on angiogenesis. Vascular endothelial growth factor is a mediator of angiogenesis. In this study we investigated whether vascular endothelial growth factor is associated with the natural course of the disease in primary invasive breast cancer. In 574 tumours of patients with node-negative invasive breast cancer the cytosolic levels of vascular endothelial growth factor were measured using a quantitative enzyme-linked immunosorbent assay. These patients did not receive adjuvant systemic therapy and were followed for a median follow-up time of 61 months (range 2–155 months) after the primary diagnosis. Correlations with well-known prognostic factors, and univariate and multivariate survival analyses were performed. Vascular endothelial growth factor level was positively associated with age and tumour size (P=0.042 and P=0.029, respectively). In addition, vascular endothelial growth factor level was inversely, but weakly correlated with progesterone receptor levels (PgR) (rs=−0.090, P=0.035). A high vascular endothelial growth factor level (equal or above the median level of 0.53 ng mg−1 protein) predicted a reduced relapse-free survival and overall survival in the univariate survival rate analysis (for both P=0.005). In the multivariate analysis as well, vascular endothelial growth factor showed to be an independent predictor of poor relapse-free survival and overall survival (P=0.045 and P=0.029, respectively), in addition to age, tumour size and PgR. The results show that cytosolic levels of vascular endothelial growth factor in tumour tissue samples are independently indicative of prognosis for patients with node-negative breast cancer who were not treated with adjuvant systemic therapy. This implies that vascular endothelial growth factor is related with the natural course of breast cancer progression

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis

Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical assistance. The work was carried out with the financial support of Telethon (GGP11021) and AIRC.Peer reviewedPostprin

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria

Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets. In this study, we report that the long isoform of the cellular FLICE-inhibitory protein (c-FLIPL), a well- known inhibitor of the extrinsic cell death initiator caspase-8, localizes at the endoplasmic reticulum (ER) and mitochondria-associated membranes (MAMs). ER morphology was disrupted and ER Ca2+-release as well as ER-mitochondria tethering were decreased in c-FLIP-/- mouse embryonic fibroblasts (MEFs). Mechanistically, c-FLIP ablation resulted in enhanced basal caspase-8 activation and in caspase-mediated processing of the ER-shaping protein reticulon-4 (RTN4) that was corrected by re-introduction of c-FLIPL and caspase inhibition, resulting in the recovery of a normal ER morphology and ER-mitochondria juxtaposition. Thus, the caspase-8 inhibitor c-FLIPL emerges as a component of the MAMs signaling platforms, where caspases appear to regulate ER morphology and ER-mitochondria crosstalk by impinging on ER-shaping proteins like the RTN4

Modelling the dispersion of particle numbers in five European cities

We present an overview of the modelling of particle number concentrations (PNCs) in five major European cities, namely Helsinki, Oslo, London, Rotterdam, and Athens, in 2008. Novel emission inventories of particle numbers have been compiled both on urban and European scales. We used atmospheric dispersion modelling for PNCs in the five target cities and on a European scale, and evaluated the predicted results against available measured concentrations. In all the target cities, the concentrations of particle numbers (PNs) were mostly influenced by the emissions originating from local vehicular traffic. The influence of shipping and harbours was also significant for Helsinki, Oslo, Rotterdam, and Athens, but not for London. The influence of the aviation emissions in Athens was also notable. The regional background concentrations were clearly lower than the contributions originating from urban sources in Helsinki, Oslo, and Athens. The regional background was also lower than urban contributions in traffic environments in London, but higher or approximately equal to urban contributions in Rotterdam. It was numerically evaluated that the influence of coagulation and dry deposition on the predicted PNCs was substantial for the urban background in Oslo. The predicted and measured annual average PNCs in four cities agreed within approximatelyPeer reviewe