Amplitude to phase conversion of InGaAs pin photo-diodes for femtosecond lasers microwave signal generation

When a photo-diode is illuminated by a pulse train from a femtosecond laser, it generates microwaves components at the harmonics of the repetition rate within its bandwidth. The phase of these components (relative to the optical pulse train) is known to be dependent on the optical energy per pulse. We present an experimental study of this dependence in InGaAs pin photo-diodes illuminated with ultra-short pulses generated by an Erbium-doped fiber based femtosecond laser. The energy to phase dependence is measured over a large range of impinging pulse energies near and above saturation for two typical detectors, commonly used in optical frequency metrology with femtosecond laser based optical frequency combs. When scanning the optical pulse energy, the coefficient which relates phase variations to energy variations is found to alternate between positive and negative values, with many (for high harmonics of the repetition rate) vanishing points. By operating the system near one of these vanishing points, the typical amplitude noise level of commercial-core fiber-based femtosecond lasers is sufficiently low to generate state-of-the-art ultra-low phase noise microwave signals, virtually immune to amplitude to phase conversion related noise.Comment: 7 pages, 6 figures, submitted to Applied Physics

A clock network for geodesy and fundamental science

Leveraging the unrivaled performance of optical clocks in applications in fundamental physics beyond the standard model, in geo-sciences, and in astronomy requires comparing the frequency of distant optical clocks truthfully. Meeting this requirement, we report on the first comparison and agreement of fully independent optical clocks separated by 700 km being only limited by the uncertainties of the clocks themselves. This is achieved by a phase-coherent optical frequency transfer via a 1415 km long telecom fiber link that enables substantially better precision than classical means of frequency transfer. The fractional precision in comparing the optical clocks of three parts in $10^{17}$ was reached after only 1000 s averaging time, which is already 10 times better and more than four orders of magnitude faster than with any other existing frequency transfer method. The capability of performing high resolution international clock comparisons paves the way for a redefinition of the unit of time and an all-optical dissemination of the SI-second.Comment: 14 pages, 3 figures, 1 tabl

Chronic T cell receptor stimulation unmasks NK receptor signaling in peripheral T cell lymphomas via epigenetic reprogramming.

Peripheral T cell lymphomas (PTCLs) represent a significant unmet medical need with dismal clinical outcomes. The T cell receptor (TCR) is emerging as a key driver of T lymphocyte transformation. However, the role of chronic TCR activation in lymphomagenesis and in lymphoma cell survival is still poorly understood. Using a mouse model, we report that chronic TCR stimulation drove T cell lymphomagenesis, whereas TCR signaling did not contribute to PTCL survival. The combination of kinome, transcriptome, and epigenome analyses of mouse PTCLs revealed a NK cell-like reprogramming of PTCL cells with expression of NK receptors (NKRs) and downstream signaling molecules such as Tyrobp and SYK. Activating NKRs were functional in PTCLs and dependent on SYK activity. In vivo blockade of NKR signaling prolonged mouse survival, demonstrating the addiction of PTCLs to NKRs and downstream SYK/mTOR activity for their survival. We studied a large collection of human primary samples and identified several PTCLs recapitulating the phenotype described in this model by their expression of SYK and the NKR, suggesting a similar mechanism of lymphomagenesis and establishing a rationale for clinical studies targeting such molecules

Development of a NiTi Anterior Cruciate Ligament Prosthesis

For the development of a Shape Memory Alloy (SMA) ligament prosthesis model, it is necessary to overcome the problem of the fatigue life under mechanical loading of nickel titanium wires. The degradation of the superelastic parameters as a function of the cyclic strain was evaluated and the number of cycles to failure under controled strain was established. On the basis of these results, an orientation in the design of the SMA ligament prosthesis can be proposed

Fatigue Life of Superelastic Springs for an Anterior Cruciate Ligament Prosthesis

The fatigue behavior of NiTi and copper based shape memory springs destined to be integrated into an anterior cruciate ligament prosthesis has been investigated and compared to the fatigue life of NiTi wires of low diameter. The degradation of the superelastic parameters has been evaluated and the number of cycles until rupture has been plotted as a function of the internal strain. The influence of the solicitation mode on the fatigue life of Shape Memory structures is pointed out

Real-time vibration rejection in an absolute atomic gravimeter

International audienc

Real-time vibration rejection in an absolute atomic gravimeter

International audienc