304 research outputs found
The contact binary VW Cephei revisited: surface activity and period variation
Context. Despite the fact that VW Cephei is one of the well-studied contact
binaries in the literature, there is no fully consistent model available that
can explain every observed property of this system.
Aims. Our motivation is to obtain new spectra along with photometric
measurements, to analyze what kind of changes may have happened in the system
in the past two decades, and to propose new ideas for explaining them.
Methods. For the period analysis we determined 10 new times of minima from
our light curves, and constructed a new OC diagram of the system. Radial
velocities of the components were determined using the cross-correlation
technique. The light curves and radial velocities were modelled simultaneously
with the PHOEBE code. All observed spectra were compared to synthetic spectra
and equivalent widths of the H line were measured on their differences.
Results. We have re-determined the physical parameters of the system
according to our new light curve and spectral models. We confirm that the
primary component is more active than the secondary, and there is a correlation
between spottedness and the chromospheric activity. We propose that flip-flop
phenomenon occurring on the primary component could be a possible explanation
of the observed nature of the activity. To explain the period variation of VW
Cep, we test two previously suggested scenarios: presence of a fourth body in
the system, and the Applegate-mechanism caused by periodic magnetic activity.
We conclude that although none of these mechanisms can be ruled out entirely,
the available data suggest that mass transfer with a slowly decreasing rate
gives the most likely explanation for the period variation of VW Cep.Comment: 13 pages, 18 figures, 9 tables, accepted for publication in Astronomy
and Astrophysic
Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment
Genetic studies have linked the primate-specific gene locus G72 to the development of schizophrenia and bipolar disorder. Transgenic mice carrying the entire gene locus express G72 mRNA in dentate gyrus (DG) and entorhinal cortex, causing altered electrophysiological properties of their connections. These transgenic mice exhibit behavioral alterations related to psychiatric diseases, including cognitive deficits that can be reversed by treatment with N-acetylcysteine, which was also found to be effective in human patients. Here, we show that G72 transgenic mice have larger excitatory synapses with an increased amount of N-methyl-d-aspartate (NMDA) receptors in the molecular layer of DG, compared with wild-type littermates. Furthermore, transgenic animals have lower number of dentate granule cells with a parallel, but an even stronger decrease in the number of excitatory synapses in the molecular layer. Importantly, we also show that treatment with N-acetylcysteine can effectively normalize all these changes in transgenic animals, resulting in a state similar to wild-type mice. Our results show that G72 transcripts induce robust alterations in the glutamatergic system at the synaptic level that can be rescued with N-acetylcysteine treatment
Testing SNe Ia distance measurement methods with SN 2011fe
The nearby, bright, almost completely unreddened Type Ia supernova 2011fe in
M101 provides a unique opportunity to test both the precision and the accuracy
of the extragalactic distances derived from SNe Ia light curve fitters. We
apply the current, public versions of the independent light curve fitting codes
MLCS2k2 and SALT2 to compute the distance modulus of SN 2011fe from
high-precision, multi-color (BVRI) light curves. The results from the two
fitting codes confirm that 2011fe is a "normal" (not peculiar) and only
slightly reddened SN Ia. New unreddened distance moduli are derived as 29.21
+/- 0.07 mag (D ~ 6.95 +/- 0.23$ Mpc, MLCS2k2), and 29.05 +/- 0.07 mag (6.46
+/- 0.21 Mpc, SALT2). Despite the very good fitting quality achieved with both
light curve fitters, the resulting distance moduli are inconsistent by 2 sigma.
Both are marginally consistent (at ~1 sigma) with the HST Key Project distance
modulus for M101. The SALT2 distance is in good agreement with the recently
revised Cepheid- and TRGB-distance to M101. Averaging all SN- and Cepheid-based
estimates, the absolute distance to M101 is ~6.6 +/- 0.5 Mpc.Comment: 8 pages, 7 figures, accepted for publication in A&
The Bajnok-Janik formula and wrapping corrections
We write down the simplified TBA equations of the string
sigma-model for minimal energy twist-two operators in the sl(2) sector of the
model. By using the linearized version of these TBA equations it is shown that
the wrapping corrected Bethe equations for these states are identical, up to
O(g^8), to the Bethe equations calculated in the generalized L\"uscher approach
(Bajnok-Janik formula). Applications of the Bajnok-Janik formula to
relativistic integrable models, the nonlinear O(n) sigma models for n=2,3,4 and
the SU(n) principal sigma models, are also discussed.Comment: Latex, 22 pages, published versio
On the Series of +CG Lightning Strokes in Dancing Sprite Events
In dancing sprite events, sprite entities and groups appear in rapid succession together with a corresponding series of parent lightning strokes. Dancing sprite events, including a case with possible sprite rebrightening, were recorded on video simultaneously from two observation sites above a mesoscale convective system in Central Europe on the night of 6 August 2013. Joint analysis of triangulated locations of sprite elements, position, type, and peak current of lightning strokes from the LINET lightning detection network database and current moment waveforms deduced at the Hylaty station, Poland, showed that subsequent sprite‐parent lightning strokes occurred no further than 21 km from the closest preceding sprite entity in the cases analyzed in this study. Additionally, it was found that longer sprite delay times tend to correspond to larger sprite location offsets from the parent +CG stroke. These observations, the occurrence of +CG lightning stroke and sprite sequences, as well as sprite‐sprite delay times and displacements can be explained if +CG strokes are part of one extended lightning flash. A corresponding production mechanism based on previous findings on the formation of sprite‐producing and general +CG lightning discharges is suggested
Two tagging single‐nucleotide polymorphisms to capture HLA ‐ DRB1*07:01–DQA1*02:01–DQB1*02:02 haplotype associated with asparaginase hypersensitivity
Aims: Asparaginase (ASP) hypersensitivity is a well-known challenge in the treatment of lymphoblastic malignancies. In terms of cost considerations, the cheap native Escherichia coli ASP, the most immunogenic form of this medication, is used in the first line in middle-income countries. Previously, the role of the HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype had been established to associate with E. coli ASP hypersensitivity. We investigated a possible cost-effective genetic testing method to identify patients harbouring the risk HLA haplotype in order to pave the way for safer ASP treatment.
Methods: In 241 patients with previously determined HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype and known ASP hypersensitivity status, 4 candidate HLA-tagging single-nucleotide polymorphisms (SNP)s were measured, and the performance of the different sets of these tag SNPs was evaluated.
Results: We identified a combination of 2 SNPs - rs28383172 and rs7775228 - as a tag for HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype with sensitivity and specificity values >95%. In line with previous findings, we found complete concordance between HLA-DRB1*07:01 and rs28383172. With bioinformatics methods, the results were also confirmed in the 1000 Genomes dataset in different ethnic groups.
Conclusion: Rs28383172 and rs7775228 are suitable for identifying HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 carriers. Compared to the rest of the population, patients with hypersensitivity-prone genotype would benefit more from the administration of less immunogenic PEGylated ASP before the hypersensitivity evolves, incurring minimal extra cost
Additional psychometric data for the Spanish Modified Dental Anxiety Scale, and psychometric data for a Spanish version of the Revised Dental Beliefs Survey
<p>Abstract</p> <p>Background</p> <p>Hispanics comprise the largest ethnic minority group in the United States. Previous work with the Spanish Modified Dental Anxiety Scale (MDAS) yielded good validity, but lower test-retest reliability. We report the performance of the Spanish MDAS in a new sample, as well as the performance of the Spanish Revised Dental Beliefs Survey (R-DBS).</p> <p>Methods</p> <p>One hundred sixty two Spanish-speaking adults attending Spanish-language church services or an Hispanic cultural festival completed questionnaires containing the Spanish MDAS, Spanish R-DBS, and dental attendance questions, and underwent a brief oral examination. Church attendees completed the questionnaire a second time, for test-retest purposes.</p> <p>Results</p> <p>The Spanish MDAS and R-DBS were completed by 156 and 136 adults, respectively. The test-retest reliability of the Spanish MDAS was 0.83 (95% CI = 0.60-0.92). The internal reliability of the Spanish R-DBS was 0.96 (95% CI = 0.94-0.97), and the test-retest reliability was 0.86 (95% CI = 0.64-0.94). The two measures were significantly correlated (Spearman's rho = 0.38, p < 0.001). Participants who do not currently go to a dentist had significantly higher MDAS scores (t = 3.40, df = 106, p = 0.003) as well as significantly higher R-DBS scores (t = 2.21, df = 131, p = 0.029). Participants whose most recent dental visit was for pain or a problem, rather than for a check-up, scored significantly higher on both the MDAS (t = 3.00, df = 106, p = 0.003) and the R-DBS (t = 2.85, df = 92, p = 0.005). Those with high dental fear (MDAS score 19 or greater) were significantly more likely to have severe caries (Chi square = 6.644, df = 2, p = 0.036). Higher scores on the R-DBS were significantly related to having more missing teeth (Spearman's rho = 0.23, p = 0.009).</p> <p>Conclusion</p> <p>In this sample, the test-retest reliability of the Spanish MDAS was higher. The significant relationships between dental attendance and questionnaire scores, as well as the difference in caries severity seen in those with high fear, add to the evidence of this scale's construct validity in Hispanic samples. Our results also provide evidence for the internal and test-retest reliabilities, as well as the construct validity, of the Spanish R-DBS.</p
- …