Magnetized Ekman Layer and Stewartson Layer in a Magnetized Taylor-Couette Flow

In this paper we present axisymmetric nonlinear simulations of magnetized Ekman and Stewartson layers in a magnetized Taylor-Couette flow with a centrifugally stable angular-momemtum profile and with a magnetic Reynolds number below the threshold of magnetorotational instability. The magnetic field is found to inhibit the Ekman suction. The width of the Ekman layer is reduced with increased magnetic field normal to the end plate. A uniformly-rotating region forms near the outer cylinder. A strong magnetic field leads to a steady Stewartson layer emanating from the junction between differentially rotating rings at the endcaps. The Stewartson layer becomes thinner with larger Reynolds number and penetrates deeper into the bulk flow with stronger magnetic field and larger Reynolds number. However, at Reynolds number larger than a critical value $\sim 600$, axisymmetric, and perhaps also nonaxisymmetric, instabilities occur and result in a less prominent Stewartson layer that extends less far from the boundary.Comment: 24 pages, 12 figures, accepted by PRE, revision according to referee

Second primary malignancies in thyroid cancer patients

The late health effects associated with radioiodine ((131)I) given as treatment for thyroid cancer are difficult to assess since the number of thyroid cancer patients treated at each centre is limited. The risk of second primary malignancies (SPMs) was evaluated in a European cohort of thyroid cancer patients. A common database was obtained by pooling the 2-year survivors of the three major Swedish, Italian, and French cohorts of papillary and follicular thyroid cancer patients. A time-dependent analysis using external comparison was performed. The study concerned 6841 thyroid cancer patients, diagnosed during the period 1934-1995, at a mean age of 44 years. In all, 17% were treated with external radiotherapy and 62% received (131)I. In total, 576 patients were diagnosed with a SPM. Compared to the general population of each of the three countries, an overall significantly increased risk of SPM of 27% (95% CI: 15-40) was seen in the European cohort. An increased risk of both solid tumours and leukaemias was found with increasing cumulative activity of (131)I administered, with an excess absolute risk of 14.4 solid cancers and of 0.8 leukaemias per GBq of (131)I and 10(5) person-years of follow-up. A relationship was found between (131)I administration and occurrence of bone and soft tissue, colorectal, and salivary gland cancers. These results strongly highlight the necessity to delineate the indications of (131)I treatment in thyroid cancer patients in order to restrict its use to patients in whom clinical benefits are expected

Systematic Review of Potential Health Risks Posed by Pharmaceutical, Occupational and Consumer Exposures to Metallic and Nanoscale Aluminum, Aluminum Oxides, Aluminum Hydroxide and Its Soluble Salts

Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007). Challenges encountered in carrying out the present review reflected the experimental use of different physical and chemical Al forms, different routes of administration, and different target organs in relation to the magnitude, frequency, and duration of exposure. Wide variations in diet can result in Al intakes that are often higher than the World Health Organization provisional tolerable weekly intake (PTWI), which is based on studies with Al citrate. Comparing daily dietary Al exposures on the basis of “total Al”assumes that gastrointestinal bioavailability for all dietary Al forms is equivalent to that for Al citrate, an approach that requires validation. Current occupational exposure limits (OELs) for identical Al substances vary as much as 15-fold. The toxicity of different Al forms depends in large measure on their physical behavior and relative solubility in water. The toxicity of soluble Al forms depends upon the delivered dose of Al+ 3 to target tissues. Trivalent Al reacts with water to produce bidentate superoxide coordination spheres [Al(O2)(H2O4)+ 2 and Al(H2O)6 + 3] that after complexation with O2•−, generate Al superoxides [Al(O2•)](H2O5)]+ 2. Semireduced AlO2• radicals deplete mitochondrial Fe and promote generation of H2O2, O2 • − and OH•. Thus, it is the Al+ 3-induced formation of oxygen radicals that accounts for the oxidative damage that leads to intrinsic apoptosis. In contrast, the toxicity of the insoluble Al oxides depends primarily on their behavior as particulates. Aluminum has been held responsible for human morbidity and mortality, but there is no consistent and convincing evidence to associate the Al found in food and drinking water at the doses and chemical forms presently consumed by people living in North America and Western Europe with increased risk for Alzheimer\u27s disease (AD). Neither is there clear evidence to show use of Al-containing underarm antiperspirants or cosmetics increases the risk of AD or breast cancer. Metallic Al, its oxides, and common Al salts have not been shown to be either genotoxic or carcinogenic. Aluminum exposures during neonatal and pediatric parenteral nutrition (PN) can impair bone mineralization and delay neurological development. Adverse effects to vaccines with Al adjuvants have occurred; however, recent controlled trials found that the immunologic response to certain vaccines with Al adjuvants was no greater, and in some cases less than, that after identical vaccination without Al adjuvants. The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances

Intensified and attenuated waves in a microbubble Taylor–Couette flow

The effect of the presence of microbubbles on a flow state is experimentally investigated in a Taylor-Couette flow with azimuthal waves, in order to examine the interaction mechanism of bubbles and flows that result in drag reduction. The average diameter of the bubbles is 60 mu m, which is smaller than the Kolmogorov length scale, and the maximum void fraction is 1.2x10(-4) at the maximum case. The modifications of the fluid properties, bulk density, effective viscosity, and the extra energy input caused by the addition of microbubbles are expected to have a small effect on modifying flow states. The power of the basic wave propagating in the azimuthal direction is enhanced; its modulation, however, is decreased by adding microbubbles in the flow regime corresponding to modulated Taylor vortex flow. Moreover, the gradient of the azimuthal velocity near the walls, source of the wall shear stress, decreases by 10%. The modified velocity distribution by adding microbubbles is comparable to that obtained with a 20% lower Reynolds number. Microbubbles in the coherent structure of the wavy Taylor vortices are visualized and exhibit a preferential distribution and motion at the crests and troughs of the waviness. The roles of the inhomogeneously distributed microbubbles in wavy vortical structures are discussed in view of our findings. (C) 2013 AIP Publishing LLC