Transcriptional and conformational changes of the tau molecule in Alzheimer's disease

Mutations in the tau gene cause frontotemporal dementia with parkinsonism, presumably by affecting the balance between tau isoforms (with either three or four microtubule-binding repeats) or by impairing tau-tubulin binding. Although to date no mutations have been found for Alzheimer's disease, it is plausible that tangle pathology in this disorder is also driven by similar molecular modifications. Investigations of Alzheimer brain tissue with new technologies such as laser capture microscopy, quantitative PCR and fluorescence lifetime imaging will shed light on whether transcriptional or conformational alterations play a role in Alzheimer pathogenesis

Evaluating Multiple Arthropod Taxa as Indicators of Invertebrate Diversity in Old Fields

Biodiversity, often quantified by species richness, is commonly used to evaluate and monitor the health of ecosystems and as a tool for conservation planning. The use of one or more focal taxa as surrogates or indicators of larger taxonomic diversity can greatly expedite the process of biodiversity measurement. This is especially true when studying diverse and abundant invertebrate fauna. Before indicator taxa are employed, however, research into their suitability as indicators of greater taxonomic diversity in an area is needed. We sampled invertebrate diversity in old fields in southern Michigan using pitfall trapping and morphospecies designations after identification to order or family. Correlation analysis was used to assess species richness relationships between focal arthropod taxa and general invertebrate diversity. Relationships were assessed at two fine spatial scales: within sampling patches, and locally across four sampling patches. Cumulative richness of all assessed taxa increased proportionately with cumulative invertebrate richness as sampling intensity increased within patches. At the among-patch scale, we tentatively identified Hemiptera and Coleoptera as effective indicator taxa of greater invertebrate richness. Although Hymenoptera, Araneae and Diptera exhibited high species richness, their total richness within patches was not associated with overall invertebrate richness among patches. Increased sampling throughout the active season and across a greater number of habitat patches should be conducted before adopting Hemiptera and Coleoptera as definitive indicators of general invertebrate richness in the Great Lakes region. Multiple sampling techniques, in addition to pitfall trapping, should also be added to overcome capture biases associated with each technique

Assessment of high speed internet for remote sensing data acquisition and exchange in Colombia and Latin America

New remote sensing platforms and data programs have dramatically increased the availability of satellite image data for analysis of climate, agriculture, environment and society. Particularly important new sensor systems include the USA’s MODIS system, Brazil and China’s CBER platform, and India’s IRS satellite. These and other systems have created considerable benefits to the international community of remote sensing analysts. Today, we have more data with greater options regarding spatial, radiometric and temporal resolution. While having these greater options is a positive development, substantial problems remain in acquiring and managing large data volumes. Data providers and consumers must support significant costs in copying remote sensing data to tapes and disks. Internet transfer of satellite imagery is only possible on broadband networks. Even then, download times can be considerable. Downloads may be interrupted if the Internet connections are unstable. How can we improve the acquisition of large volumes of remote sensing data for environmental analysis? What alternatives are available to remote sensing researchers to acquire near-real time satellite imagery for research use? This paper assesses the potential of high-speed Internet as a medium for transferring large satellite imagery data sets between the United States and Colombia, between Colombia and other Latin American countries and within Colombia. Academic and research networks have led developments in high-speed Internet. Many countries throughout the world are installing the infrastructure needed to develop these networks. In the United States this system is referred to as Internet 2. Latin American countries are developing a system called RedCLARA (Cooperación Latinoamerican

Comparison between disordered quantum spin 1/2 chains

We study the magnetic properties of two types of one dimensional XX spin 1/2 chains. The first type has only nearest neighbor interactions which can be either antiferromagnetic or ferromagnetic and the second type which has both nearest neighbor and next nearest neighbor interactions, but only antiferromagnetic in character. We study these systems in the presence of low transverse magnetic fields both analytically and numerically. Comparison of results show a close relation between the two systems, which is in agreement with results previously found in Heisenberg chains by means of a numerical real space renormalization group procedure.Comment: 7 page

Thermal properties of solid and porous tungsten at temperatures to 5000 deg F

Thermal properties of solid and porous tungsten at high temperature

Thermal conductivity of hydrogen from 2000 deg to 4700 deg F

Thermal conductivity of hydrogen from 2000 to 4700 degrees Fahrenhei

Ground State and Magnetization Process of the Mixture of Bond-Alternating and Uniform S=1/2 Antiferromagnetic Heisenberg Chains

The mixture of bond-alternating and uniform S=1/2 antiferromagnetic Heisenberg chains is investigated by the density matrix renormalization group method. The ground state magnetization curve is calculated and the exchange parameters are determined by fitting to the experimentally measured magnetization curve of \CuCl$_{2x}$Br$_{2(1-x)}$($\gamma$-pic)$_2$. The low field behavior of the magnetization curve and low temperature behavior of the magnetic susceptibility are found to be sensitive to whether the bond-alternation pattern (parity) is fixed all over the sample or randomly distributed. The both quantities are compatible with the numerical results for the random parity model.Comment: 5 pages, 7 figures. Final and enlarged version accepted for publication in J. Phys. Soc. Jp

Actively Contracting Bundles of Polar Filaments

We introduce a phenomenological model to study the properties of bundles of polar filaments which interact via active elements. The stability of the homogeneous state, the attractors of the dynamics in the unstable regime and the tensile stress generated in the bundle are discussed. We find that the interaction of parallel filaments can induce unstable behavior and is responsible for active contraction and tension in the bundle. Interaction between antiparallel filaments leads to filament sorting. Our model could apply to simple contractile structures in cells such as stress fibers.Comment: 4 pages, 4 figures, RevTex, to appear in Phys. Rev. Let

Real Space Renormalization Group Study of the S=1/2 XXZ Chains with Fibonacci Exchange Modulation

Ground state properties of the S=1/2 antiferromagnetic XXZ chain with Fibonacci exchange modulation are studied using the real space renormalization group method for strong modulation. The quantum dynamical critical behavior with a new universality class is predicted in the isotropic case. Combining our results with the weak coupling renormalization group results by Vidal et al., the ground state phase diagram is obtained.Comment: 9 pages, 9 figure