ASSESSMENT OF EMPLOYEE MOTIVATION AND DEMOTIVATION AS PARAMETERS OF THE “DIGITAL TWIN OF AN ORGANIZATIONʹS MODEL”

“Digital double” is a rapidly developing technology in recent years. The term “digital double” appeared a long time ago. For more than thirty years, digital doubles, as virtual representatives of real objects, have been used, in particular, in the space sphere. However, this technology became widely known at the time of the beginning of digitalization processes in order to activate the functioning and development of business. The article explores the possibility of using the resource model “Digital twin of an organization” to describe human behavior in specific situations. The probability of choosing an action is determined from a variety of  alternatives, based on an assessment of the significance of perceived incentives and restrictions. When predicting human behavior, along with external incentives, internal motives for actions and actions should also be taken into account

Influence of physical loading on behavioral reactions of rats in cerebral hypoperfusion

A number of clinical studies demonstrate that individual characteristics such as stress tolerance and cognitive ability can be considered not only as diagnostic variables but also as risk factors for severe cerebral hypoperfusion. The aim of the study was to identify the typological features of the effect of physical activity on the behavioral reactions of rats during cerebral hypoperfusion. Material and methods. Cerebral hypoperfusion was modeled by bilateral carotid artery ligation. The study involved 280 rats, divided into equal subgroups, according to sex, stress tolerance and learning capacity. Of these, 112 animals were subjected to daily short-term swimming as a rehabilitation model. Before the simulation, and at 6, 8, 14, 21, 28, 35, 60 and 90 days postoperatively, the animals were tested using a Morris water maze and an “open field” test. Results and discussion. The dynamics of stress resistance and learning ability are related to the periodicity of inflammatory, necrotic, circulatory and reparative remodeling in the model used. After 2-3 months of study, cerebral hypoperfusion causes stabilization of indices characterizing stress resistance and cognitive functions below control values. A decrease in stress resistance begins earlier from day 6 of the study, while the index characterizing cognitive functions first decreases significantly after 3 weeks of study. Factors reducing the damaging effects of cerebral hypoperfusion were female gender, high baseline stress tolerance and learning ability. When assessing learning ability under physical load, animals with high baseline cognitive development showed earlier recovery dynamics during urgent adaptation and a significant increase during long-term adaptation

EDUCATIONAL MOTIVATION OF UNDERGRADUATE STUDENTS AS AN INDICATOR OF THE QUALITY OF EDUCATION

The motivation as one of the key indicators of the quality of higher education, as a powerful driver of the educational process, and one of the main catalysts of personal and professional growth of the student has been considered. The results of the diagnosis of the level of motivation and structure of the motivational complex, carried out with the help of two psychological techniques, modified by the authors of the article, have been briefly outlined and displayed. Possible reasons for the “lack” of motivation among students of management specialties have been identified. Meanwhile, it has been offered to look on the lack of motivation a little wider, than the authors were able to identify in the analysis of sources on this theme. Possible directions of optimization of motivational structure of future managers have been studied. The vector of further studies of educational motivation as an indicator of the quality of management education has been outlined

METHODICAL APPROACHES TO THE FORMATION OF ADAPTIVE MANAGEMENT STRUCTURES

The article has been devoted to the formation of adaptive organizational management structures. The essence of structures and their relationship with other elements of the control system have been analyzed. Adaptability and flexibility are considered as the most important indicators of the efficiency of structures, their ability to ensure sustainable functioning and innovative development of enterprises. The mechanism of formation of adaptive structures has been presented. The issues about the quality of adaptation, the adaptive characteristics of the structure and their consistency with the level and quality of adaptation of other elements of the enterprise, the interface of adaptability and flexibility, the pace of change have been raised. It has been concluded, that the structure is not effective, if it does not seek adaptability. Meanwhile, the process of adaptation should be innovative and ensure effective innovation and technological development of the enterprise

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120

BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations inactivated HIV-1, herpesvirus types 1 (HSV-1) and 2 (HSV-2) and the major nonviral sexually transmitted disease (STD) pathogens and were effective in animal models for vaginal infection by HSV-2 and simian immunodeficiency virus. METHODS: Enzyme-linked immunoassays and flow cytometry were used to demonstrate CAP binding to HIV-1 and to define the binding site on the virus envelope. RESULTS: 1) CAP binds to HIV-1 virus particles and to the envelope glycoprotein gp120; 2) this leads to blockade of the gp120 V3 loop and other gp120 sites resulting in diminished reactivity with HIV-1 coreceptors CXCR4 and CCR5; 3) CAP binding to HIV-1 virions impairs their infectivity; 4) these findings apply to both HIV-1 IIIB, an X4 virus, and HIV-1 BaL, an R5 virus. CONCLUSIONS: These results provide support for consideration of CAP as a topical microbicide of choice for prevention of STDs, including HIV-1 infection

УСПЕШНОЕ ЛЕЧЕНИЕ ОБШИРНОГО ГЛУБОКОГО ОЖОГА У РЕБЕНКА С ЕДИНСТВЕННОЙ ЛЕВОЙ ПОЧКОЙ И ОТСУТСТВИЕМ СЕЛЕЗЕНКИ

We report a case of successful treatment in a child with extensive deep burns of the trunk and lower limbs with a flame in the absence of the right kidney and spleen.Представлен случай успешного лечения ребенка с обширным глубоким ожогом пламенем туловища и нижних конечностей при отсутствии у пациента правой почки и селезенки

Background free search for neutrinoless double beta decay with GERDA Phase II

The Standard Model of particle physics cannot explain the dominance of matter over anti-matter in our Universe. In many model extensions this is a very natural consequence of neutrinos being their own anti-particles (Majorana particles) which implies that a lepton number violating radioactive decay named neutrinoless double beta ($0\nu\beta\beta$) decay should exist. The detection of this extremely rare hypothetical process requires utmost suppression of any kind of backgrounds. The GERDA collaboration searches for $0\nu\beta\beta$ decay of $^{76}$Ge (^{76}\rm{Ge} \rightarrow\,^{76}\rm{Se} + 2e^-) by operating bare detectors made from germanium with enriched $^{76}$Ge fraction in liquid argon. Here, we report on first data of GERDA Phase II. A background level of $\approx10^{-3}$ cts/(keV$\cdot$kg$\cdot$yr) has been achieved which is the world-best if weighted by the narrow energy-signal region of germanium detectors. Combining Phase I and II data we find no signal and deduce a new lower limit for the half-life of $5.3\cdot10^{25}$ yr at 90 % C.L. Our sensitivity of $4.0\cdot10^{25}$ yr is competitive with the one of experiments with significantly larger isotope mass. GERDA is the first $0\nu\beta\beta$ experiment that will be background-free up to its design exposure. This progress relies on a novel active veto system, the superior germanium detector energy resolution and the improved background recognition of our new detectors. The unique discovery potential of an essentially background-free search for $0\nu\beta\beta$ decay motivates a larger germanium experiment with higher sensitivity.Comment: 14 pages, 9 figures, 1 table; ; data, figures and images available at http://www.mpi-hd.mpg/gerda/publi

Characterization of 30 76^{76}Ge enriched Broad Energy Ge detectors for GERDA Phase II

The GERmanium Detector Array (GERDA) is a low background experiment located at the Laboratori Nazionali del Gran Sasso in Italy, which searches for neutrinoless double beta decay of $^{76}$Ge into $^{76}$Se+2e$^-$. GERDA has been conceived in two phases. Phase II, which started in December 2015, features several novelties including 30 new Ge detectors. These were manufactured according to the Broad Energy Germanium (BEGe) detector design that has a better background discrimination capability and energy resolution compared to formerly widely-used types. Prior to their installation, the new BEGe detectors were mounted in vacuum cryostats and characterized in detail in the HADES underground laboratory in Belgium. This paper describes the properties and the overall performance of these detectors during operation in vacuum. The characterization campaign provided not only direct input for GERDA Phase II data collection and analyses, but also allowed to study detector phenomena, detector correlations as well as to test the strength of pulse shape simulation codes.Comment: 29 pages, 18 figure