Trigger and readout electronics for the STEREO experiment

The STEREO experiment will search for a sterile neutrino by measuring the anti-neutrino energy spectrum as a function of the distance from the source, the ILL nuclear reactor. A dedicated electronic system, hosted in a single microTCA crate, was designed for this experiment. It performs triggering in two stages with various selectable conditions, processing and readout via UDP/IPBUS of 68 photomultiplier signals continuously digitized at 250 MSPS. Additionally, for detector performance monitoring, the electronics allow on-line calibration by driving LED synchronously with the data acquisition. This paper describes the electronics requirements, architecture and the performances achieved.Comment: Topical Workshop on Electronics for Particle Physics (TWEPP) 2015, Lisboa. 9 pages, 9 figure

Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging

The concept of brain maintenance refers to the preservation of brain integrity in older age, while cognitive reserve refers to the capacity to maintain cognition in the presence of neurodegeneration or aging‐related brain changes. While both mechanisms are thought to contribute to individual differences in cognitive function among older adults, there is currently no “gold standard” for measuring these constructs. Using machine‐learning methods, we estimated brain and cognitive age based on deviations from normative aging patterns in the Whitehall II MRI substudy cohort (N = 537, age range = 60.34–82.76), and tested the degree of correspondence between these constructs, as well as their associations with premorbid IQ, education, and lifestyle trajectories. In line with established literature highlighting IQ as a proxy for cognitive reserve, higher premorbid IQ was linked to lower cognitive age independent of brain age. No strong evidence was found for associations between brain or cognitive age and lifestyle trajectories from midlife to late life based on latent class growth analyses. However, post hoc analyses revealed a relationship between cumulative lifestyle measures and brain age independent of cognitive age. In conclusion, we present a novel approach to characterizing brain and cognitive maintenance in aging, which may be useful for future studies seeking to identify factors that contribute to brain preservation and cognitive reserve mechanisms in older age

Spectral Energy Distributions of Be and Other Massive Stars

We present spectrophotometric data from 0.4 to 4.2 microns for bright, northern sky, Be stars and several other types of massive stars. Our goal is to use these data with ongoing, high angular resolution, interferometric observations to model the density structure and sky orientation of the gas surrounding these stars. We also present a montage of the H-alpha and near-infrared emission lines that form in Be star disks. We find that a simplified measurement of the IR excess flux appears to be correlated with the strength of emission lines from high level transitions of hydrogen. This suggests that the near-IR continuum and upper level line fluxes both form in the inner part of the disk, close to the star.Comment: 2010, PASP, 122, 37

Exploring variability in basal ganglia connectivity with functional MRI in healthy aging.

Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behavior, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches. Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of aging on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging

Pulsational instability of yellow hypergiants

Instability of population I (X=0.7, Y=0.02) massive stars against radial oscillations during the post-main sequence gravitational contraction of the helium core is investigated. Initial stellar masses are in the range from 65M_\odot to 90M_\odot. In hydrodynamic computations of self-exciting stellar oscillations we assumed that energy transfer in the envelope of the pulsating star is due to radiative heat conduction and convection. The convective heat transfer was treated in the framework of the theory of time-dependent turbulent convection. During evolutionary expansion of outer layers after hydrogen exhaustion in the stellar core the star is shown to be unstable against radial oscillations while its effective temperature is Teff > 6700K for Mzams=65M_\odot and Teff > 7200K for mzams=90M_\odot. Pulsational instability is due to the \kappa-mechanism in helium ionization zones and at lower effective temperature oscillations decay because of significantly increasing convection. The upper limit of the period of radial pulsations on this stage of evolution does not exceed 200 day. Radial oscillations of the hypergiant resume during evolutionary contraction of outer layers when the effective temperature is Teff > 7300K for Mzams=65M_\odot and Teff > 7600K for Mzams=90M_\odot. Initially radial oscillations are due to instability of the first overtone and transition to fundamental mode pulsations takes place at higher effective temperatures (Teff > 7700K for Mzams=65M_\odot and Teff > 8200K for Mzams=90M_\odot). The upper limit of the period of radial oscillations of evolving blueward yellow hypergiants does not exceed 130 day. Thus, yellow hypergiants are stable against radial stellar pulsations during the major part of their evolutionary stage.Comment: 20 pages, 7 gigures. Accepted for publication in Astronomy Letter

Search for astronomical neutrinos from blazar TXS 0506+056 in super-kamiokande

We report a search for astronomical neutrinos in the energy region from several GeV to TeV in the direction of the blazar TXS 0506+056 using the Super-Kamiokande detector following the detection of a 100 TeV neutrinos from the same location by the IceCube collaboration. Using Super-Kamiokande neutrino data across several data samples observed from 1996 April to 2018 February we have searched for both a total excess above known backgrounds across the entire period as well as localized excesses on smaller timescales in that interval. No significant excess nor significant variation in the observed event rate are found in the blazar direction. Upper limits are placed on the electron- and muon-neutrino fluxes at the 90% confidence level as 6.0 × 10−7 and 4.5 × 10−7–9.3 × 10−10 [erg cm−2 s−1], respectively

Association of long-term diet quality with hippocampal volume: longitudinal cohort study

BACKGROUND: Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume. METHODS: Analyses were based on 459 participants of the Whitehall Brain Imaging substudy (mean age 59.6[SD=5.3] years in 2002/04, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-16). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation/registration tool was applied to extract hippocampal volumes. RESULTS: Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampus volume. For each 1 standard deviation (SD, 8.7 points) increment in AHEI-2010, an increase of 92.5mm3 (SE=42.0mm3) in total hippocampal volume was observed. This association was independent of socio-demographic factors, smoking habits, physical activity, cardio-metabolic health factors, cognitive impairment and depressive symptoms, and was more pronounced in left hippocampus than in right hippocampus . Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampus volume. CONCLUSIONS: Higher long-term AHEI-2010 scores were associated with larger hippocampal volumes. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging