A collection of lower thermospheric /100 to 300 km altitude/ chemical composition, temperature, and mass density data

Tabulated lower thermospheric chemical composition, temperature, and mass density dat

The structure of insulin at the air/water interface: monomers or dimers?

The hydrophobic character of the air/water interface affects the oligomeric composition of insulin. By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities chi(2), we show that insulin monomers segregate to the air/water interface

Intrinsisch ungeordnete Osteopontin-Fragmente ordnen sich während der interfazialen Calciumoxalat-Mineralisierung

Calcium oxalate (CaC(2)O(4)) is the major component of kidney stone. The acidic osteopontin (OPN) protein in human urine can effectively inhibit the growth of CaC(2)O(4) crystals, thereby acting as a potent stone preventer. Previous studies in bulk solution all attest to the importance of binding and recognition of OPN at the CaC(2)O(4) mineral surface, yet molecular level insights into the active interface during CaC(2)O(4) mineralization are still lacking. Here, we probe the structure of the central OPN fragment and its interaction with Ca(2+) and CaC(2)O(4) at the water–air interface using surface‐specific non‐linear vibrational spectroscopy. While OPN peptides remain largely disordered in solution, our results reveal that the bidentate binding of Ca(2+) ions refold the interfacial peptides into well‐ordered and assembled β‐turn motifs. One critical intermediate directs mineralization by releasing structural freedom of backbone and binding side chains. These insights into the mineral interface are crucial for understanding the pathological development of kidney stones and possibly relevant for calcium oxalate biomineralization in general

Chemo-Archaeological Downsizing in a Hierarchical Universe: Impact of a Top Heavy IGIMF

We make use of a semi-analytical model of galaxy formation to investigate the origin of the observed correlation between [a/Fe] abundance ratios and stellar mass in elliptical galaxies. We implement a new galaxy-wide stellar initial mass function (Top Heavy Integrated Galaxy Initial Mass Function, TH-IGIMF) in the semi-analytic model SAG and evaluate its impact on the chemical evolution of galaxies. The SFR-dependence of the slope of the TH-IGIMF is found to be key to reproducing the correct [a/Fe]-stellar mass relation. Massive galaxies reach higher [a/Fe] abundance ratios because they are characterized by more top-heavy IMFs as a result of their higher SFR. As a consequence of our analysis, the value of the minimum embedded star cluster mass and of the slope of the embedded cluster mass function, which are free parameters involved in the TH-IGIMF theory, are found to be as low as 5 solar masses and 2, respectively. A mild downsizing trend is present for galaxies generated assuming either a universal IMF or a variable TH-IGIMF. We find that, regardless of galaxy mass, older galaxies (with formation redshifts > 2) are formed in shorter time-scales (< 2 Gyr), thus achieving larger [a/Fe] values. Hence, the time-scale of galaxy formation alone cannot explain the slope of the [a/Fe]-galaxy mass relation, but is responsible for the big dispersion of [a/Fe] abundance ratios at fixed stellar mass.We further test the hyphothesis of a TH-IGIMF in elliptical galaxies by looking into mass-to-light ratios, and luminosity functions. Models with a TH-IGIMF are also favoured by these constraints. In particular, mass-to-light ratios agree with observed values for massive galaxies while being overpredicted for less massive ones; this overprediction is present regardless of the IMF considered.Comment: 24 pages, 15 figures, 2 tables. (Comments most welcome). Summited to MNRA

Cryptorchidism and hypospadias in sons of gardeners and farmers.

Cryptorchidism and hypospadias have been related to prenatal estrogen exposure in animal models. Some chemicals used in farming and gardening have been shown to possess estrogenic and other hormone-disrupting effects. Earlier studies have indicated increased risks of urogenital malformations in the sons of pesticide appliers. In the present study, parental occupation in the farming and gardening industry among 6,177 cases of cryptorchidism, 1,345 cases of hypospadias, and 23,273 controls, born live from 1983 to 1992 in Denmark, was investigated in a register-based case-control study. A significantly increased risk of cryptorchidism but not hypospadias was found in sons of women working in gardening (adjusted odds ratio = 1.67; 95% confidence interval, 1.14-2.47). The risks were not increased in sons of men working in farming or gardening. The increased risk of cryptorchidism among sons of female gardeners could suggest an association with prenatal exposure to occupationally related chemicals

The Influence of postpartum posttraumatic Stress Disorders on the childhood Development: a population-based Two-year follow-up Study

Background. Against the background of very limited evidence, the present study aimed to prospectively examine the impact of maternal postpartum PTSD symptoms on four important areas of child development, i.e. gross motor, fine motor, communication, and social-emotional development. Methods. This study is part of the large, population based Akershus Birth Cohort. Data from the hospital’s birth record as well as questionnaire data from 8 weeks and 2 years postpartum were used (n=1,472). The domains of child development that were significantly correlated with PTSD symptoms were entered into regression analyses. Interaction analyses were run to test whether the influence of postpartum PTSD symptoms on child development was moderated by child sex or infant temperament. Results. Postpartum PTSD symptoms had a prospective relationship with poor child social-emotional development two years later. This relationship remained significant even when adjusting for confounders such as maternal depression and anxiety or infant temperament. Both child sex and infant temperament moderated the association between maternal PTSD symptoms and child socialemotional development, i.e. with increasing maternal PTSD symptom load, boys and children with a difficult temperament showed to have comparatively higher levels of social-emotional problems. Conclusions. Examining four different domains of child development, we found a prospective impact of postpartum PTSD symptoms on children’s social-emotional development at two years of age. Our findings suggest that both boys and children with an early difficult temperament may be particularly susceptible to the adverse impact of postpartum PTSD symptoms. Additional studies are needed to further investigate the mechanisms at work

The scale-free character of the cluster mass function and the universality of the stellar IMF

Our recent determination of a Salpeter slope for the IMF in the field of 30 Doradus (Selman and Melnick 2005) appears to be in conflict with simple probabilistic counting arguments advanced in the past to support observational claims of a steeper IMF in the LMC field. In this paper we re-examine these arguments and show by explicit construction that, contrary to these claims, the field IMF is expected to be exactly the same as the stellar IMF of the clusters out of which the field was presumably formed. We show that the current data on the mass distribution of clusters themselves is in excellent agreement with our model, and is consistent with a single spectrum {\it by number of stars} of the type $n^\beta$ with beta between -1.8 and -2.2 down to the smallest clusters without any preferred mass scale for cluster formation. We also use the random sampling model to estimate the statistics of the maximal mass star in clusters, and confirm the discrepancy with observations found by Weidner and Kroupa (2006). We argue that rather than signaling the violation of the random sampling model these observations reflect the gravitationally unstable nature of systems with one very large mass star. We stress the importance of the random sampling model as a \emph{null hypothesis} whose violation would signal the presence of interesting physics.Comment: 9 pages emulateap